فهرست مطالب nahid naghizadeh

Glioblastoma multiforme is the foremost common harmful tumor of the central nervous system that specifically influences the brain and is resistent to common therapies such as surgery, radiotherapy and chemotherapy. The aim of this study was to examine the viability of perseverance preparing and Nano-curcumin supplementation on the expression of miR-21 and P53 qualities in brain tumor tissue in a creature demonstrate of glioblastoma multiforme.  In this experiment, 35 8-week-old male Wistar rats were divided into seven groups with 5 rats each: healthy control group, 4-week-old healthy, control group cancer, 4-week-old cancer group and training group, Nano-curcumin group and training-Nano-curcumin group. Cancer cells were injected into the right frontal cortex of mice using a pump at a depth of 2.5 mm. One week later, mice entered the treadmill training program (4 weeks) and Nano-curcumin was administered orally at a dose of 80 mg/kg (28 days). Gene expression was measured using real-time fluorescent quantitative PCR and used for analysis.spss software.  The expression of miR-21 gene in the training group, Nano-curcumin, and training group Nano-curcumin was lower than that of the control cancer at 4 weeks (P = 0.001). Moreover, the expression of P53 gene in the Nano-curcumin training group and Nano-curcumin training group was higher in cancer cells and 4-week blood-eating cancer than in the control group (P = 0.001).  Endurance training and curcumin administration appear to reduce tumor growth in mice with brain tumors by modulating the expression of miR-21 and p53 genes.

In the article published in volume 33, issue 226, 2023, the title was published incorrectly, which is now corrected.

Background &

Brain tumors are one of the deadliest malignancies that can directly affect the brain, and are often accompanied by executive function and memory disorders. The aim of this research was to investigate the effectiveness of endurance exercise and nano curcumin consumption on short-term memory of rats with glioblastoma multiforme brain tumor.
Materials &

In this experimental study, 35 healthy male Wistar rats were randomly divided into seven groups of five including: the basic healthy control group, 4-week healthy control, basic cancer control, 4-week cancer control, cancer + nano curcumin group, cancer + exercise, and cancer + practice + nano curcumin. One week after the injection of cancer cells into the frontal cortex, the animals entered the main exercise program on the treadmill (4 weeks, 18 m/min, and 3 days a week). In the end, the rats were sacrificed, the data were collected, and the results were analyzed using one-way analysis of variance and Tukey's post hoc statistical tests.

The results showed that endurance exercise and nano curcumin consumption significantly reduced the tumor volume in the cancer + exercise + nano curcumin group (P= 0.001), and also caused a significant increase in short-term memory in the studied groups compared to the 4-week cancer group (P= 0.001).

Probably, performing endurance exercises along with the use of nano curcumin can improve short-term memory in rats with brain tumors, in addition to reducing tumor volume.