فهرست مطالب nargess tabarzan
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BackgroundMultiple duodenal and jejuno-ileal atresias are extremely uncommon. The familial occurrence of multiple intestinal atresias is even more unusual. Also fetal death with isolated intestinal atresia is very rare، and the combination of recurrent familial intestinal atresias and intra-uterine fetal death has not been reported previously.Case PresentationWe report on two cases of intra-uterine fetal death in a 30-year-old woman who is consanguineous with her husband and they have only one boy who carries chromosomal abnormality. To best of our knowledge this is the first reported case of two consecutive pregnancies with multiple intestinal atresias leading to intrauterine fetal death.ConclusionMultiple and recurrent intestinal atresias are extremely uncommon. These rare cases may contribute to genetic mapping for intestinal atresias.
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Background And ObjectiveMale breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER and PR) and prognostic factors (p53 and Her-2/neu) in a series of male patients with breast cancer and correlate them with tumor grade and stage.Materials And MethodsFifty cases of breast carcinoma in male patients, retrieved from the files of the Cancer Institute from 1996 until 2005 was included in this study.ResultsMost of the cases were categorized as grade 2 (65.3%), grade 1 cases comprised 20.4% and grade 3 was 14.3%. Stage IIb was the largest group (32%). Estrogen receptor was detected in 90% of cases and progesterone receptor in 68% of cases and no significant correlation was found between estrogen and progesterone receptor positivity and tumor grade or stage. In addition, p53 and Her-2/ neu staining revealed positivity in 11 cases (27.5%) and 13 cases (26%) respectively with strong positivity in only 6 cases and no significant correlation was found between tumor grade and stage and p53 expression. It is clear from our data that Her-2/neu positivity in MBC is lower than in female breast carcinoma.ConclusionThis study, which comprises rather large series of MBC in Iran during a 10-year period, shows that most patients refer in rather late stages and prognostic factors such as p53 and Her-2/neu has no significant correlation with tumor grade and stage at presentation in our patients.
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Muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. One explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. In mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respiratory chain function or secondarily to peripheral neuropathy with neurogenic muscle atrophy. The clinical manifestations of mitochondrial myopathies are variable and include muscle weakness,exercise induced cramps ad myalgia. Also, ptosis and progressive external ophtalmoplegia are typical but not obligate finding. Hereby we wanted to report a case of mitochondrial myopathy, diagnosed by histochemical and electron microscopic studies for the first time in Iran. Our case was a 12-years old girl who referred due to muscle weakness to our center which started at an age of 8 years. Later, she also developed ptosis. EMG studies were inclusive and muscle biopsy revealed typical red ragged fibers with special staining. By electron microscopy, typicalmitochondrial changes were detected.
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