فهرست مطالب nasim shayan

Coronary artery disease is the leading cause of death in most countries. Although the relationship between spirituality and health has been confirmed in various studies, the relation in this specific case has not been investigated. Therefore, the present study was conducted to investigate the relationship of spirituality with morbidity and mortality in patients with coronary artery disease who underwent CABG surgery. This cross-sectional study was performed on patients with coronary artery disease who had undergone CABG at Dr. Shariati Hospital in Tehran over the time period from December 2012 to December 2013. The data collection tools were a data gathering checklist based on patients' records and respective physician's confirmation and the Spirituality questionnaire (Hall and Edwards, 1996). Data were analyzed using Mann-Whitney, Kruskal-Wallis, and Spearman correlation coefficient. All ethical issues were observed in this study and the authors of the article have not reported any conflicts of interest. The findings of the relationship between the six subscales of spirituality with morbidity and mortality showed that with an increase in the median score of disappointment subscale, the incidence of infection, tamponade, PVC and AF increased and by increasing the median score of awareness subscale, the incidence rate decreased (P<0.05). There was a significant positive correlation between the hospital stay and disappointment subscale (P=0.003, r=0.291). Mortality also decreased in patients who were more knowledgeable (p<0.05). The results of the research indicate that spirituality correlates with the incidence of morbidity and mortality after CABG surgery. Therefore, effective solutions such as considering the spiritual issues in the patients' treatment process and training appropriate psychological techniques should be used to expedite their recovery.

The occurrence of Atrial Fibrillation (AF) is linked to an increased inflam-matory response after cardiac surgery that is significantly decreased by anti-inflammatory treatments. The present study aimed at administrating Colchicine as a way to reduce the incidence of post- Coronary Artery Bypass Graft (CABG) atrial fibrillation. In this double-blind، parallel clinical trial، 216 patients with coronary artery disease who underwent CABG surgery، by using a table of random numbers are divided into intervention and control groups to receive placebo or Colchicine. The clinical and surgical characteristics of the patients in two groups were similar. The intervention group received 1. 0 mg of Colchicine tab، the night before surgery and on the morning of surgery. This drug followed by 0. 5 mg twice a day for five days after surgery. On the other hand patients in the control group received only placebo (ineffective pill with similar size to Colchicine). After operation two groups were compared regarding important outcomes such as postoperative arrhythmia، ICU stay and hospital stay. The data were assessed using SPSS software (version 17) and t-test and 2 statistical tests. One hundred fifty six men and sixty women with a mean age of 59. 9±9. 3 years were enrolled in the study in two Colchicine and placebo groups (each consisting of 108 patients). The incidence of postoperative atrial fibrillation was 14. 8% in the Col-chicine group and 30. 6% in the control group (P= 0. 006). ICU stay in the Colchicine group were 2. 4±1. 3 days versus 3. 1±1. 5 days in controls (P< 0. 001) and hospital stay in the Colchicine group were 6. 6±1. 5 days versus 8. 1±2. 0 days in controls (P< 0. 001). Colchicine is an anti-inflammatory medication and has very few side effects at low doses. According to the 48% reduction in the incidence of atrial fibrillation in Colchicine patients undergoing coronary artery bypass grafting surgery، this drug can be prescribed as a prophylaxis for prevention of post-CABG atrial fibrillation.

Atrial fibrillation is the most common arrhythmia after cardiac surgery. Vitamin C as an antioxidant has an important role in reducing the incidence of postop-erative atrial fibrillation. The present study aimed at administrating vitamin C as a way to reduce the incidence of post-CABG atrial fibrillation. In this double-blind، parallel clinical trial، 170 patients with coronary artery disease who underwent CABG surgery، by using a table of random numbers are di-vided into intervention and control groups to receive placebo or vitamin C. The clinical and surgical characteristics of the patients in the two groups were similar. The interven-tion group received 2 mg of vitamin C intravenously، the night before surgery. This drug followed by 500 mg، twice a day for five days after surgery. On the other hand patients in the control group received placebo (normal saline intravenously). After operation two groups were compared regarding Important outcomes such as postoperative arrhythmia، ICU stay and hospital stay. One hundred eighteen men and fifty two women with a mean age of 59. 1±9. 8 years were enrolled in the study in two vitamin C and placebo groups (each consisting of 85 patients). The incidence of postoperative atrial fibrillation was 12. 9% in the vita-min C group and 29. 4% in the control group (P=0. 009). ICU stay in the vitamin C group were 2. 5±1. 4 days versus 3. 0±1. 6 days in controls (P=0. 035) and hospital stay in the vitamin C group were 6. 6±1. 5 days versus 8. 2±2. 3 days in controls (P<0. 001). Vitamin C is relatively safe، inexpensive، well tolerated and has a low complication. According to the 44% reduction in the incidence of atrial fibrillation in vitamin C patients undergoing coronary artery bypass grafting surgery، this drug can be prescribed as a prophylaxis for prevention of post-CABG atrial fibrillation.