فهرست مطالب nazanin mortazavi

Oral cancer is the sixth most common cancer in the world and the third most common cancer in developing countries. Early detection of oral cancer can reduce mortality in several ways. The aim of the present study was to combine the quantitative results of various studies concerning serum and salivary microRNAs for early diagnosis of head and neck squamous cell carcinoma (HNSCC).

This systematic review and meta-analysis was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guideline. We searched all the relevant English studies in international databases of PubMed/Medline, Scopus, Web of Science, Cochrane, ProQuest, Embase, and Wiley until February 2022. A random-effects model was used to estimate the pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) for each study. A total of 672 articles were found. After screening, 93 articles were approved for systematic review. Finally, 5 completely relevant articles were examined in the meta-analysis.

Considering all studies regarding miRNAs, the combined results indicated that AUC  =  0.73, with a sensitivity of 71.68% and a specificity of 69.95%, could be used for HNSCC diagnosis. Due to the moderate sensitivity and specificity of miRNAs, they may be able to confirm or exclude suspected cases of this disease, enhancing their utility as clinical diagnostic indicators.

The available data provide evidence that miRNAs, especially MiR-31 expression in the saliva, serum, or plasma, can be used as a diagnostic biomarker for HNSCC patients. However, controlled clinical trials with large sample sizes are needed to validate different miRNAs.

Oral and dental health are crucial for nutrition intake, speech, and facial aesthetics. They also significantly influence individuals' physical, social, and psychological activities. This study aimed to determine the relationship between the Dental Caries Index (DMFT) and oral health-related quality of life.

This descriptive-analytical study was conducted on 61 patients (29 men and 32 women) aged 20-50 years who visited the Gorgan Dental School Clinic, Iran during 2019. The DMFT index, encompassing Decay (D), Missing (M), and Filled (F) teeth, was calculated. Quality of life was assessed using the 36-item DIDL (Dental Impact on Daily Living) questionnaire, which covers five domains: dental appearance and aesthetics, oral comfort, overall oral and dental function, eating limitations, and dental and jaw pain. Scores were categorized into three groups: dissatisfied (below 0), moderately satisfied (0 to 7), and satisfied (above 7).

The mean score for oral health-related quality of life was 5.14±0.229, indicating a relative level of satisfaction. Pearson's correlation coefficient between DMFT and oral health-related quality of life was -0.358, suggesting a significant inverse relationship between DMFT and quality of life (P<0.05). The mean DMFT score ranged from 0 to 28, with a mean of 9.36, and the most frequent scores were 7, 11, and 13, each accounting for 11.5% of the sample. The mean decay (D) score was 3.44, the mean missing (M) score was 1.98, and the mean filled (F) score was 3.93, with ranges of 0-12, 0-19, and 0-13, respectively.

The results of this study indicate an inverse impact of the Dental Caries Index on patients' quality of life. Oral health-related quality of life is a multifaceted construct that affects various aspects such as appearance, oral comfort, and eating limitations, which are critical components of overall quality of life and satisfaction.

Determination of the exact working length is one of the most important steps in root canal treatment. Various devices and methods, such as electronic apex locators, have been developed for the determination of the working length. The present study aimed to compare the accuracy of four electronic apex locators, DTE, Denjoy, Woodpecker and Coxo, in determining the actual working length.

In this descriptive study, fourty mandibular premolar teeth that fulfilled the inclusion criteria were selected and examined. First, each tooth was measured with four apex locators. The electronic measurements were performed following the manufacturers’ instructions within ±0.5 mm, ±1 mm and exactly at apical constriction. To calculate the actual working length, 4 mm of the root end was buccolingually cut from buccal side of the canal, and the distance between the coronal reference point and apical constriction was measured under a microscope. Then, data were analysed with Paired T test.

. Within ±0.5 mm from the apical constriction and at the apical constriction, the accuracy of apex locators DTE, Woodpecker, Coxo and Denjoy were 87% and 45%, 85% and 37%, 85% and 45% and 82% and 42%, respectively. All specimens measured with four types of apex locators were within the range of -1 to +1 mm to the apex with an accuracy of 97.5%.

 None of the four apex locators reported an accuracy of 100% at apical constriction. There was no statistically significant difference between the working length measured by four apex locators and the actual working length.

Temporomandibular joint (TMJ) disorders, known as TMDs, are significant public health problems and may result in pain and disability. In order to determine the prevalence of clinical/subjective TMD in rheumatoid arthritis (RA), we used the research diagnostic criteria (RDC)/TMD axes. We assessed the anti-cyclic citrullinated protein (anti-CCP)-related TMD in RA for the first time. Fifty-two RA patients were compared to 47 healthy controls with regard to complete blood count (CBC), serology, acute phase reactants (APR), and TMJ dysfunction. The anti-CCP antibody showed a significant correlation with the development of clinical TMD (P=0.001, 95% confidence interval (CI)=12.4%-35.6%). A prevalence of 50% was calculated through the RDC/TMD for such disorders. In RA patients, statistically significant differences were observed between the groups with and without clinical TMD regarding psychological depression and physical symptoms. According to the results, a significant correlation was found between the anti-CCP antibody and TMD. Therefore, when this antibody is detected in the blood serum, the treatment must be initiated. The RDC/TMD used in this study assessed the prevalence of TMJ dysfunction in conformity with RA-associated TMJ findings previously obtained through other conventional methods

In comparison with oral and systemic temporomandibular joint (TMJ) medications, topical analgesics are the safest, still effective, pharmacological agents that are being used to treat temporomandibular disorders (TMDs). To select the appropriate topical agents for the treatment of various TMDs, their active ingredients and mechanisms of action should be well-understood. As for oral or systemic pharmacotherapeutics, topical analgesics can be used in combination with alternative treatments for TMDs.This review focuses on the current topical agents used in TMDs. An advanced search of publications from 2000 to 2016 was made in ScienceDirect, PubMed, Medline, and Google Scholar databases. Only English‑language articles were included in our study.

Endodontic files which are used to clean and shape the root canal space differ from each other regarding technical specifications. Recently, K-type files are repeatedly studied on their cutting efficiency. This study aims to evaluate the tip design and cutting efficiency of 5 brands of K-files, available in Iran dental market (naming Dentsply, Thomas, Mani, Perfect and Larmrose).
Methods and Materials: In this descriptive study, topographic features of file tips were investigated by the scanning electron microscope (SEM). Those features included tip symmetry, tip design, tip angle, and the distance from the tip to the lowest flute. SEM images (×250 magnification) of files were prepared. Statistical tests (Fisher's exact test, Chi-square, ANOVA, and t test) were used and P Dentsply files had the most number of morphologically pyramidal sharp tips and the greatest tip angles. However, Larmrose files were the most frequent files having cutting sharp tips. Symmetrical tips existed among 100% of Dentsply and Mani brands. No significant differences were found with respect to distance from the file tip to the lowermost flute between different file brands of this study (P=0.2, One way ANOVA).
Dentsply and Mani files possessed the most symmetrical tips and greatest tip angles. With respect to tip length, all 5 brands were satisfactory. However, neither of 5 brands evaluated topographically were outstanding in every aspect.

Totalantioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation.
Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences. Salivary TAC and MDA were determined by biochemical analyses before and after 5-week triamcinolone acetonide (0.2%) mouthrinse treatment. Subjective symptoms as well as lesion status pre- and post-treatment were measured using visual analog scale (VAS) and clinical scoring system, respectively. Wilcoxon signed rank test was used for the evaluation of MDA and TAC parameters, VASs, and rates of clinical scores. Spearman’s rank correlation was used to determine the relationship between different variables.
A statistically significant increase in salivary TAC was found after treatment. There was no significant difference in the reduction of salivary MDA levels in OLP patients after treatment.
Posttreatment analyses revealed a significant degree of recovery and pain relief of OLP lesions. Hence, triamcinolonmouthrinse by reducing oxidative stress is an appropriate treatment in OLP patients.

Palisaded encapsulated (solitary circumscribed) neuromas (PENs) are relatively common intraoral neurogenic tumors, which occur most frequently on the hard palate. Herein, we describe the clinicopathological characteristics of a palisaded encapsulated neuroma of the tongue. This tumor was an exophytic sessile mass measuring 0.3× 0.4 cm with rubbery consistency on the anterior one-third of the dorsum of the tongue. The tumor was excised under the impression of a pyogenic granuloma (PG). No recurrence was reported at 12 months postoperatively. Histopathological examination showed a well-circumscribed mass that composed of interlacing fascicles of spindle cells. The cells were S-100 positive. The nuclei, showing parallel orientation within the fascicles, were wavy and pointed and showed no sign of mitotic activity. Giemsa staining revealed no mast cells within the stroma.