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Antihistamine drugs for acute upper respiratory tract infection treatment inchildren have many side effects. In this study, a anti-cough syrup was prepared from Cordia (Sepestanin Persian) extract and its effect was compared to that of diphenhydramine syrup on cough relief of childrenwith upper respiratory tract infection.

This double-blind randomized clinical trial was conducted on 124 children withupper respiratory tract infection aged 6-12 years referred to Abouzar Hospital in Ahvaz, Iran during 2019-2021 in two treatment groups. The first group was given Sepestan syrup at a dose of 20 mg/kg/day andthe second group received diphenhydramine syrup at a dose of 5 mg/kg/day in four dosages. For threedays, the number and severity of day-time and night-time coughs were examined and the data wereanalyzed with independent t-test and chi-square test in SPSS software, version 24.

The number and severity of day-time and night-time coughs in the group received Sepestan syrupsignificantly decreased compared to the diphenhydramine group, without any side effects (P<0.001).

High polysaccharides, strong antioxidants, and anti-inflammatory compounds of Sepestan canreduce throat irritation and soften the chest. The mucilage in the Sepestan extract can dissolve in waterand produce a viscous substance such as gelatin that cause softening of the breast and expectoration.

Acute gastroenteritis in children is a major cause of morbidity in the world. This study investigated the effect of suspension prepared from date seed in reducing the severity and duration of diarrhea in gastroenteritis pediatrics.

Participants in this clinical trial study comprised 140 gastroenteritis pediatrics referred to Abuzar Children’s Hospital in Ahvaz. Eligible patients were randomly assigned to experimental and control groups. The intervention group was given 5% date seed suspension in the amount of 12 mg/kg of body weight orally once every 8 hours for 7 days; the control group was administered a placebo three times a day. Then the two groups were compared for severity and duration of diarrhea as well as stool volume.

The duration and severity of diarrhea were significantly less in children in the intervention group than in the control group (p<0.05). The mean duration of diarrhea in the intervention and control groups was 3.508±1.102 and 4.680±4.001 days, respectively. The mean severity of diarrhea, decreased at 24 hours (2.0857±0.607; 1.8571±0.747), 48 hours (1.7429±0.695; 1.2571±0.695), 72 hours (1.1000±0.695; 0.7857±0.814), and 96 hours (0.5429±0.629; 0.4143±0.577) after the intervention and was lower in the intervention group than the control group, and the difference between the two groups was significant (p=0.001). Moreover, stool consistency was higher in the intervention group than in the control group after the consumption of date seed suspension (p<0.05).

Our results confirm the effectiveness of the herbal medicine prepared from date seed waste for control and treatment of gastroenteritis.

Sulfuric acid functionalized magnetic nanocatalyst (SAMNC) has been prepared as an efficientacidic and applied in the one-pot preparation of 2,3-dihydroquinazolin-4 (1H) -one derivatives.This catalyst has been characterized by FT-IR, SEM, and VSM. According to the obtainedresults, including time, yield and recyclability, SAMNC could be considered as an efficient catalystfor organic transformations.