noushin salimi

In this study, Fe3O4/SiO2/GO nanocomposites were investigated as a pH-responsive nanocarrier for the loading and release of the anticancer drug curcumin. Fe3O4/SiO2/GO nanoparticles were synthesized by thermal treatment method and characterized and drug delivery properties were investigated using VSM, FTIR, SEM, UV-visible, EDX, and, TEM techniques. The size of Fe3O4/SiO2/GO nanocomposites was about 56 nm. The X-ray diffraction pattern results of Fe3O4/SiO2/GO nanocomposite showed the presence of crystalline, cubic, and tetragonal phases with a crystal size of 14.79 nm, and the VSM results showed the ferromagnetic behavior at room temperature .The results of FTIR analysis and SEM images before and after drug loading confirmed the functionalization of nanocomposites with curcumin. The loading capacity of curcumin on the surface of Fe3O4/SiO2/GO nanocomposites was approximately 19.21%. The curcumin release from nanocarriers increased from 28% to 68% by changing pH from 7.4 to 4.8. Results of the MTT test showed that nanocarriers are significantly toxic on U87 cell lines in a dose-dependent manner, while they are relatively safe for human fibroblast cells.

Today, oil and gas industries are important resources for obtaining energy and income. During the production of oil and gas, very complex compounds that include organic and inorganic substances, petroleum hydrocarbons and aromatic and aliphatic compounds are transferred to the environment. benzene, toluene, ethylbenzene and xylenes, which are called BTEX for short, are very important monoaromatic pollutants. Therefore, the present study was conducted to investigate the effect of exposure to BTEX on some clinical factors of the exposed people in the oil warehouse and office workers in Kermanshah National Oil Products Distribution Company.

This cross-sectional study was conducted in 2018. The samples of this study include the personnel working in the oil warehouse and the office staff of the National Oil Products Distribution Company in Kermanshah. After completing the demographic information of the participants in terms of the inclusion criteria and after collecting the results of the physiological tests of the employees, SPSS19 software was used for statistical analysis.

The results of the present study showed that the spirometric indices decreased in the workers exposed to BTEX compounds, but it was not statistically significant. Also, the number of red blood cells (6.73%) was significantly lower in non-administrative employees, as well as red white blood cells (6.61%), SGOT (10.14%) and SGPT (5.09%) in non-administrative employees. It has been more.

The number of platelets was higher in office workers. Considering the dangers of BTEX pollution for human health, it is recommended to use preventive measures such as using a special mask and a shift work system.