o sabzevari

It has been long known that Silibinin, a naturally derived herbal phytochemical, is an effective drug for the treatment of toxic thyroid damage; however, its role in cancer treatment is still not approved and is under investigation. Besides, due to the poor water solubility and bioavailability of Silibinin and the side effects that drug payloads cause, its delivery to the point of care with a controlled release rate is challenging. In this work, we propose a protocol to prepare liposome-encapsulated Silibinin (LES) with the ability to produce reactive oxygen species (ROS) for the treatment of MCF-7 breast cancer cells. Spherical-shaped LES nanoparticles with an average size of 60 nm and narrow size distribution (PDI=0.11) were synthesized by the thin film hydration method. Studies of the pharmacokinetics showed that a burst release occurred during the first 12 h that was followed by a sustained release over the next 12 days. MTT assays and the analysis of the drug effect determined that LES nanoparticles displayed a significant cytotoxic effect to kill breast cancer cells. IC50 values for LES nanoparticles were experimentally determined to be 20 μМ which was significantly lower than that of the pristine drug (38 μМ).....

Nowadays, the Aquaculture industry has played a major role in dealing with a broad range requirements for human protein needs. Though environmental pollution and the incidence of the disease have always been the significant challenges in the use of aquatic products. Increasing the antibiotic resistance rate in fish pathogens has attracted attention to searching for alternatives to antibiotics. In this regard, nanotechnology as a new and innovative strategy has a range of applications in aquaculture and preserving sea animals and can provide a reliable way to protect farmed fish from pathogens. The producers, therefore, try to eliminate barriers in food fields using nano-based tools and cause growth, proliferation, aquaculture, and water purification to increase production in the aquaculture industry. One of the most outstanding issues that researchers point out nano-scale is finding appropriate methodologies for the synthesis of environment-friendly and non-toxic nanoparticles. The specific chemical, physical and biological properties of nanoparticles have increased the incentive to produce them. Today these agents have found their way into many medical applications, including detection, vaccinations, medicine, and gene transfer. Moreover, the use of nanoparticle-based vaccines for many viral pathogens is a developing field in fish disease research. So, Nanoparticles have been widely taken into consideration as a special and sensitive tool to identify bacterial, fungal and viral diseases in aquaculture. This study focuses on the antimicrobial effects of nanoparticles, especially antibiotic-resistant bacteria, and the nanotechnology applications in fisheries.

In this study, we used a simple green method for preparing tellurium nanoparticles and mainly evaluated their toxicological effects. The nanoparticles were synthesized using lactose and characterized with different instrumentation methods. The in vitro and in vivo cytotoxicity of tellurium nanoparticles and its effect on lipid profile were also evaluated. Hydroxyl-capped tellurium nanoparticles were successfully fabricated by lactose. The results showed spherical tellurium nanoparticles with a mean size of 89 nm. The toxicological study showed that the tellurium nanoparticles did not exhibit any toxicity on the primary cells. The LD50 values for the nanoparticles were 327 and 295 mg/kg for oral and intraperitoneal administrations, respectively. Also, the results showed a significant reduction in liver enzymes at the 16, 24, and 40 mg/kg doses. Hematological parameters indicated no significant suppressive changes between the animals that were administered tellurium nanoparticles and the control group. In addition, the effects of tellurium nanoparticles on hypercholesterolemic risk factors in mice fed with cholesterol demonstrated the depletion of triglyceride, cholesterol, and low-density lipoprotein. This study showed that the toxicity of tellurium nanoparticles was lower than tellurium ions. Furthermore, tellurium nanoparticles decreased the cholesterol and triglyceride levels in the animal model.

Common kilka were chilled during 1, 2, 3, 4 and 5 days to determine the influence of such storage times of fish over the quality of the final canned product. For this propose, common factors for determination of fish quality (moisture, total lipid, free fatty acid, peroxide, thiobarbituric acid and fatty acid profile) were selected and compared with the formation of fluorescence compounds in fish tissue and filling media of canned kilka. In this work common indices showed higher oxidative and hydrolytic rancidity of canned samples compared to raw material but the trend of deterioration with the increase of chilled storage time was not well shown. However, filling media fluorescence compounds was significantly increased with the increase of chilled storage time and the decrease of fish primary quality (P< 0.05). According to the present results, fluorescence detection of interaction compounds can provide a good technique to assess quality differences in the final product as its relates to the quality of the raw material used.