فهرست مطالب omid abdollahi

The emergence of drug resistance to the existing antibacterial and anti-HIV-1 therapeutics has posed an urgent medical need to develop new molecules. We describe in this regard, a series of novel N'-arylidene-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide derivatives with anti-HIV-1 and antibacterial activities were designed and synthesized in this study.

The synthesized compounds were evaluated for the blocking of both the IN ST process and cell-based HIV-1 replication. The synthesized compounds were also examined for in vitro antibacterial activities using the minimum inhibitory concentration (MIC) assay.

The results revealed the moderate antibacterial activity of the synthesized compounds. Moreover, no significant integrase inhibitory and anti-HIV-1 activities were observed for the synthesized compounds at concentrations < 100 µM.

According to the docking analyses, the orientation of the designed scaffold in the active site of integrase is similar to the other inhibitors of the HIV integrase and can be regarded as an acceptable template for further structural modification to improve potencies.

There are reports for analgesic, anti-inflammatory, hypnotic, neuroprotective and anti-oxidative effects of safranal. The aim of this study was to investigate the analgesic effects of safranal using acute pain method in rat and determine the role of GABAergic and Opioidergic pathways.

Wistar male rats were randomly divided into six groups (n=6). Experimental groups including: Control, safranal (1, 2, 4, mg/kg, ip) and the most effective dose of safranal in combination with naloxone or flumazenil receiving groups. The analgesic effect was assessed by plantar apparatus in 30, 60 and 90 min after drugs or vehicle administration.

Our results showed that safranal injection (2 mg/kg, ip) significantly increased the time delay in response to thermal inducing pain effect at 30, 60 and 90 min after injection compared with the control group(P <0.05). While, the administration of flumazenil with the same dose, prevented analgesic effect of safranal at all three times (P <0.05).

Our findings support the analgesic effect of safranal. Considering the effects of flumazenil in preventing the safranal analgesia, it seems that GABAergic system may mediate the analgesic effect of safranal.

There are several reports about analgesic, anti-depressant, anti-inflammatory, antiseptic, sedative, and anti-spasmodic effects of Jasminum sambac. The aim of this study was to investigate the analgesic effects of Jasminum sambac hydroalcoholic extract and determine the role of GABAergic and opioidergic pathways in rat model by a plantar device.
Material and Wistar male rats were randomly divided into six groups (n=6) including control, the groups treated with hydroalcoholic extract of Jasminum Sambac (100, 200, 400, mg/kg, ip) and the groups which received the most effective dose of the extract in addition to naloxone or flumazenil. The analgesic effect was assessed by plantar device after 30, 60 and 90 min of the injections.
Our results showed that injection of hydroalcoholic extract of Jasminum sambac (200 mg/kg, ip) increased significantly the time delay in response to thermal pain inducing effect at 30, 60 and 90 (P The results indicated the analgesic effect of Jasminumsambac extract. Considering the preventive effect of naloxone on the analgesia produced by Jasminum sambac, opioidergic pathway seems to be dominant in the development of Jasminum sambac analgesic effect.

This study examined changes in lipid profile in patients with severe sepsis and septic shock in comparison with non-sepsis patients admitted to the medical ICU and its association with mortality. Through sampling of internal ICU admitted patients in Seman Kostar hospital, patients were divided into two groups of sepsis (n=107) and non-septic (n=115). Then, serum level of total cholesterol, triglyceride, HDL and LDL with specific kit was evaluated randomly at first and fifth day after ICU admition.Then, two groups was compared. In sepsis and non-septic groups, 51.4% and 47% were men and the remainder was women, mean age was 74.2 and 68 years, mortality rate was 76.6% and 46.9%, respectively. In the first instance, compared with non-septic, lipid variables except triglycerides and cholesterol decreased significantly and in the second instance, cholesterol, triglycerides and LDL reduced and HDL increased. HDL in sepsis and TG at fifth day and LDL at fifth day in non-septic group was associated with mortality rate. Patients with severe sepsis and septic shock had lower levels of serum lipid profiles compared with patients without sepsis in ICU. Serum HDL in sepsis and LDL and TG in non-septic patients had prognostic role.

Otosclerosis is a disease of bony labyrinth. Structural changes in the labyrinth often cause ossicular fixation, and thus conductive hearing loss. The purpose of this study was to evaluate middle ear exploration findings and frequency of ossicular and footplate area anomalies in patients with suspected otosclerosis referred to Amiralmomenin and Golsar Hospitals in Rasht, Iran. In 47 patients undergone middle ear exploration in Amiralmomenin and Golsar hospitals from April 2001 to March 2011, the intraoperative findings, and other data were extracted from the medical records of the patients. The data was analyzed using SPSS 17 software. Frequency of fixation of stapes, malleus, and incus by age and sex in patients undergoing middle ear exploration showed that stapes had been fixed in 39 patients, malleus in 6 patients, and incus in 21 patients. Analysis of data showed that there was no significant association between sex and age with fixation of any of ossicles (P>0/05). Middle ear anomalies were seen in 16 cases (34.0%). Overhanging of facial nerve in 4 cases, thick stapedial crura in 5 cases, and perilymph gusher in 2 cases were the most frequent anomalies. This study show that the results of middle ear explorations in our patients in the north of Iran is somehow different from the typical otosclerotic cases, although the frequency of ossicular anomalies is better to be evaluated and compared in different areas of Iran, and other countries.

In today's world the companies can will benefit owners of more benefit to the best of the asset management deal.This case requires information about the company's actual performance. In this regard, appropriate measures should be used to achieve this goal. The relationship between Tobin Q ratio and the dividend per share to be named. This study examines the relationship between the Tobin Q ratio and dividend per share in the profits of companies listed in Tehran Stock Exchange deal. In this study, 100 companies listed in Tehran Stock Exchange in the period 1382 -1388 have been reviewed. The results of these tests are a test used in this study shows that the Spearman correlation coefficient between the Tobin Q ratio and the dividend per share is positively and significantly and Tobin Q ratio of dividend per share of the profits instead of replacing possibility there. In this study, Mann-Whitney test was used to determine significant differences.