parisa alipour

 Drugs containing the 4-anilinoquinazolines scaffold play a critical role in cancer treatment by inhibiting protein kinases, especially tyrosine kinases. In this study, a novel series of 4-anilinoquinazoline derivatives were synthesized and evaluated as cytotoxic agents.

 All final compounds were synthesized using two methods, including a conventional approach using potassium iodide and dimethylformamide as well as a green method using a deep eutectic solvent (DES) comprising choline chloride: urea. The cytotoxicity was tested on the A431, HUVEC, and HU02 cell lines. To evaluate the binding pattern of the compounds with EGFR and VEGFR-2, a molecular docking investigation was performed. Finally, the wound healing assay was carried out to assess the potency of compounds in inhibiting cell migration.

 The final reaction time was approximately 15-20 min with yields of 60-72% using DES, while the conventional method took 3 to 4 h to complete, with yields between 30% and 42%. Compounds 8k and 8l showed better cytotoxicity against both cell lines compared to vandetanib (IC50=0.11 µM and 0.26 µM on A431 and IC50=5.01 µM and 5.24 µM on HUVEC, respectively). Molecular docking studies revealed that compound 8k, which contained 3-methylaniline at the 4-position of the quinazoline core, showed efficient binding affinity to both EGFR and VEGFR-2. An essential hydrogen bond was formed between quinazoline N1 of 8k and the Met796 residue of EGFR with a docking score of -8.76 kcal/mol. The imidazole N3 of 8k interacted with the Cyc919 residue of VEGFR-2, forming a hydrogen bond with a docking score of -9.03 kcal/mol. Moreover, compound 8k exhibited the best inhibitory activity on cell migration and wound healing.

 DES significantly improved the time and yield of the final reactions. Compound 8k, which showed the best cytotoxicity and inhibitory activity on cell migration, could be a suitable candidate for further structural optimization.

 With regard to the increasing aesthetic solutions through makeup and plastic surgeries, high rate of cosmetics sales in Iran, and increased office visit for plastic surgeries, the purpose of this study is to analysis the effect of rhinoplasty on self-confidence and happiness of women aged 16 to 35 who were visited in private clinics in Urmia city in December 2014.

 The study performed on 40 women who have undertaken rhinoplasty, 40 women who were waiting for rhinoplasty, and a group of 40 women who have not undergone rhinoplasty. Copper Smith self-esteem questionnaire including 58 questions and Oxford Happiness Questionnaire including 29 questions have been used in this study.

 The results of student’s t-test for independent groups showed that from the aspects of self-esteem and happiness, there was a difference between the group who have done surgery and those who were standing by.
Discussion and

 The findings show that self-esteem and happiness of the people who undergone rhinoplasty is equal and even more than those who were standing by for this operation or have not taken the operation.

Although LCL filters are used widely in the grid connected inverters to reduce high-order harmonics, such a system increases system order and therefore sustainable design of closed-loop controller system will be complicated. Recently, the single-loop control strategy has been suggested for L or LC filter based grid-connected inverters. However, the use of single-loop control directly in LCL filter-based inverters may cause instability. In this paper, a new double-loop control strategy is presented which includes a voltage external loop and an internal loop of filter capacitor current. The external loop controls the input voltage of the grid-connected inverter. The internal loop improves system stability margin and removes the resonance of LCL filter. To obtain the transfer function of system, single-phase instantaneous power theory is used. The computer simulation has proved the feasibility of the proposed control.