فهرست مطالب parisa mosapour

The success rate of infertility treatment depends on many different factors.

This study aimed to determine the effect of platelet-rich plasma (PRP) on the improvement of pregnancy outcomes in participants with repeated implantation failure.

The study is a randomized triple-blind clinical trial. The study population was 118 women with repeated implantation failure during assisted reproductive technology treatment at Tabriz Jihad-e Daneshgahi ART Center from May 2017 to December 2019. Intervention: Intrauterine injection of autologous PRP. Standard treatment of fetal transfer to the uterine cavity was performed without intrauterine PRP injection in the control group: After 4 wk, the level of β-human chorionic gonadotropin hormone in participants' blood was measured.

Comparing the effect of intrauterine injection of PRP in 2 groups showed the level of β-human chorionic gonadotropin positive in the intervention group was 21 (43.8%), in the control group was 12 (26.1%), odds ratio = 2.20 (0.92-5.26) and p = 0.073.

The therapeutic effect in the intervention group compared to the control regarding the outcome of a successful pregnancy showed that intrauterine injection of PRP can be effective in improving pregnancy outcomes, although this improvement is not significant.

Recurrent miscarriage is defined as two or more abortions happening consecutively within less than the twenty weeks of gestation or when the fetus’s weight is below 500 g. Numerous factors are involved in recurrent miscarriages, the most important of which are chromosomal abnormalities and females’ genetic clotting condition, thrombophilia, including Factor II, prothrombin, and mutation. The present study aimed at investigating the relationship between the couples’ chromosomal abnormalities and prothrombin mutation in women with recurrent miscarriages in the northwest of Iran.

In the present applied research, 100 couples referring for recurrent miscarriages were subjected to cytogenetic experiments via using the GTG banding. Deep vein thrombosis tests were also conducted on the women based on the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method.

Ten out of 100 studied couples were diagnosed with chromosomal abnormalities. All these abnormalities were of structural type. Out of 100 women subjected to clotting factor II, only one heterozygous case was found while the remaining cases were healthy. The control group subjects (n=100) were also found healthy. No significant difference was evidenced between the control and patient groups.

Based on the results, 5% of the studied cases had structural chromosome abnormalities and this was in compliance with the results obtained in the prior research. As regards the prothrombin mutation, only one out of one hundred studied women was heterozygous whereas the remaining subjects were healthy; this is consistent with the results obtained in previous studies