r. hoshyar

The Amin wheat cultivar, with the pedigree "KAUZ/LUCO-M//PVN/STAR/3/ Yaco/2*Parus/4/Pishtaz", was developed through a national irrigated bread wheat breeding program for the temperate climate of Iran. Initial and advanced crosses were conducted at the Seed and Plant Improvement Institute in Karaj, Iran, while the evaluation and selection of segregating generations (F2-F6) carried out at the Zarghan Research Station in Fars Province. Selected lines, including M-94-14, advanced to both preliminary and advanced yield trials. Under optimal irrigation conditions in temperate climate adaptation trials, the M-94-14 line (Amin cultivar) achieved an average grain yield of 6950 kgha-1, representing a 3.9% and 5.7% yield advantage over the control cultivars Parsi and Baharan, which yielded 6688 and 6574 kgha-1, respectively. This line exhibited desirable baking quality traits, including favorable grain protein content, Zeleny sedimentation volume, bread loaf volume, grain hardness index, and SDS sedimentation height. Additionally, it demonstrated acceptable resistance to yellow and leaf rusts. On-farm trials across various regions showed that the Amin cultivar achieved a grain yield of 6820 kgha-1 under optimal irrigation conditions, outperforming the average grain yield of control cultivars, which was 6609 kgha-1. Given the superior performance of this line compared to existing cultivars in temperate climate of Iran, the M-94-14 line was officially released as the Amin cultivar in 2019.

In crop season 2012-2013 wheat genotype "Frncln/Rolf07" was introduced to Iran within an international nursery received from CIMMYT and was studied in experiment of evaluation of yield and agronomic characteristics of spring wheat genotypes in international nurseries in temperate regions. Then in 2013-2014 crop season, it was selected in a preliminary regional wheat yield trial under normal irrigation with an average yield of 8114 kgha-1 compared to the check cultivars Parsi, Sirvan, Pishtaz and sivand, respectively, with grain yield of 8.035, 8.022, 6.914 and 7.985 kgha-1. This cultivar was further investigated in the advanced regional wheat yield trial of temperate regions of the country during 2014-2015 and with average grain yield of 7093 kgha-1 compared to 6495 and 6423 kgha-1 yield of check cultivars Parsi and Sirvan, respectively, and was selected for adaptation evaluation. The average yield of M-94-15 line in temperate climate adaptation experiment during the 2015-2017 crop season under normal conditions was 7231 kgha-1 verses 6688 kgha-1 of Parsi cultivar and 6574 kgha-1 of Baharan cultivar and in general, total mean grain yield was 3% higher than the average of whole genotypes. Due to the good condition of M-94-15 line reaction to stripe rust (O-30MR) and leaf rust (O-30MSS) diseases, as well as the resistance to grain shattering and good bread making quality, this line was selected for study at the level of farmers' fields. Wheat line M-94-15 based on its favorable agronomic characteristics, suitable earliness and good bread making quality was released in 2019 as Farin for cultivation in temperate agro-climatic regions.

Recently, the preparation of silver nanoparticles (AgNPs) by green technique has improved due to their fundamental applications in medicine. In this study, methadone syrup (ME) was used for the preparation of AgNPs as a reducing and stabilizing agent with the aim of in vitro cytotoxicity effect against the human breast cancer cells. The characteristics of prepared particles are investigated by transmission electron microscopy (TEM), environmental scanning electron microscopy (ESEM), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS), UV–visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction studies (XRD). The AgNPs (about 18 nm) were synthesized in a spherical shape and uniform distribution. The mechanism of ME through the synthesis has been proposed based on FT-IR analysis and density functional theory. To investigate the cytotoxicity of prepared AgNPs by ME, MTT assay was used in the range of 0-100 μg/mL. As a function of its dosage, the green synthetic AgNPs showed anti-proliferation activity against MDA-MB-468 cells respect to ME. The results demonstrated the feasibility of producing AgNPs in a simple, rapid, and green manner using ME, which has an important function in inhibiting the growth of breast cancer cells.