فهرست مطالب razieh rahimian

Trichomonas vaginalis is a flagellate parasite causing vaginosis, a common sexual transmitted disease. Metronidazole is the drug of choice for this disease but due to its side effects, it is necessary to search for an alternative drug. In this study, the effect of Menthe piperita and Salvia officinalis on Trichomonas vaginalis was investigated. Hydro-alcoholic extracts of the two herbs were prepared. The extracts were dried using vacuum rotary evaporator. Different concentrations of the extracts in comparison with methronidazole were added in test tubes containing culture medium and the parasite. All test tubes were kept in 37ºC for 24 hours. The tubes were then expected for the parasite growth. In concentrations of 2, 2.5, 4, 5, 8, and 10 mg/ml of Salvia officinalis and in concentrations of 4, 5, 8, and 10 mg/ml of Menthe piperita the parasite did not grow. The effect of the extracts on Trichomonas vaginalis was similar to the effect of metronidazole on the parasite. Salvia officinalis and Menthe piperita had efficient effect against Trichomonas vaginalis growth in culture medium and s,o these two herbs can be considered as alternatives drugs. However, more investigation is recommended.

Helicobacter pylori infection is one of the most common human infections which have been associated with many upper gasterointestinal complications. Different treatment regimens for Helicobacter pylori eradication have been used. One of these regimes is the quadruple therapy regimen which metronidazole is one of the medications. In recent years several reports on H. pylori resistance to this antibiotic has been presented. This study was performed to compare the effects of garlic and peppermint extract combination with metronidazole in the treatment of Helicobacter pylori infection. In this randomized double blind clinical trial, 142 patients who were eligible for inclusion in study after completing the questionnaire and consent form were randomly divided into two groups, receiving garlic and peppermint extract or metronidazole. Moreover, for both groups the drugs; amoxicillin, omeprazole and bismuth were also administrated. Two weeks after drug administration completion, urease breath test (UBT) was performed and based on the obtained data, the recovery rate in the two groups were compare using SPSS 16 software T-test and Ki squire. The patients mean age was 43.89± 13.37 years. Evaluating the age and sex factors, we found no significant difference between two groups. Results suggest that although the combination of amoxicillin, omeprazole, bismuth plus garlic and peppermint was not successful in the eradication of Helicobacter pylori such as the quadruple therapy, but less than half of cases lead to eradication of Helicobacter pylori infection.