فهرست مطالب s. farokhi

Ulcerative colitis is an idiopathic chronic, relapsing inflammation of the colon which is resulted from dysregulation of the mucosal immune system. In Iranian traditional medicine, oleoresin from Pistacia atlantica is used to treat gastrointestinal disorders, including peptic ulcers, dyspepsia and intestinal inflammation.

In this study, we examined the therapeutic and protective effects of oleoresin in acetic acid-induced colitis in rat.

The oleoresin was dissolved in Tween 80% (1% v / v) and doses of 100, 200 and 400 mg/kg were administered orally to animals. Three days after colitis induction, the rats were treated for 6 days and after determining the most effective dose in the treatment, the protective effect was evaluated using the optimal dose of the oleoresin for 6 days. In day 6, colitis was induced and continued for 3 days. At the end, animals were sacrificed for microscopic and macroscopic examination of colon tissues.

Dose dependently, Oleoresin of P. atlantica showed therapeutic effects on microscopic and macroscopic examination of colon tissue of rats with ulcerative colitis  induced by acetic acid, in comparison with control group(P<0.05). However, there was no significant difference between treatment groups and the control in the protective method (P>0.05).

This study showed the beneficial effects of anti-inflammatory and wound healing oleoresin of P. atlantica in acetic acid- induced ulcerative colitis in rats.

The supply chain management is regarded as an important infrastructure in managing material ow. Cross docking is considered to be as an ecient method in supply chain management to control the inventory ow, which is essential in supply chain management. The other objectives of the cross dock are inventory reduction, increased levels of customer responsiveness and better control of the distribution operation. Since this system plays a key role in the supply chain, setting up multi objective approaches may help to solve real world issues and problems of such systems, in which many of the objectives are dierent and even con icting. This paper proposes a new multi-objective mathematical model which, unlike the previous works, considers transportation from suppliers to customers, from suppliers to other suppliers, from suppliers to cross sock, from cross dock to customers and from a customer node to other customer nodes. In this paper, three dierent types of objective functions are considered: to minimize the total time in supply chain, to minimize transportation cost, and to minimize the number of transportation times in the network. As mentioned earlier, these three objectives are in con ict with each other; and by considering three objective functions simultaneously the control of the supply chain is more appropriate. Since these three models belong to the NP-hard class, their solving time severely increases with increasing the problem dimensions. In this paper, to solve these three models, meta-heuristic algorithms have been used. The algorithms used in solving the model are Multiple Objective Particle Swarm Optimization and Non-Dominated Sorting Genetic Algorithm. The model is solved using both algorithms and computational experiments are reported.