فهرست مطالب s.asgary

Hypertension is a major risk factor for cardiovascular disease which is failure in endothelial function and increased arterial stiffness. Pomegranate juice is rich in bioactive polyphenols with antioxidant and cardioprotective functions. Twenty-one hypertensive patients (aged 30-67 years) were recruited into the trial and assigned to receive either PJ (150 ml/day in a single occasion between lunch and dinner; n=11) or the same amount of water (n=10) for a period of two weeks. Systolic blood pressure (SBP)، diastolic blood pressure (DBP) and flow-mediated dilation (FMD)، along with serum concentrations of lipid profile parameters and apolipoproteins A and B were measured at baseline and two weeks after PJ consumption. Statistical analysis was conducted using paired t-test for continuous variables. PJ consumption was associated with significant reductions in SBP (p=0. 002) and DBP (p=0. 038) but not FMD (p>0. 05). However، no significant effect was observed from PJ on serum levels of lipid profile parameters and apolipoproteins. PJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension.

Aloe Vera is a medicinal plant that has diverse biological properties such as antioxidant and anti-inflammatory activity. Atherosclerosis is one of the main causes of death in the world where in the new studies have been introduced as an inflammatory disease. Hence the use of lipid-lowering drugs and inflammation may be useful in preventing or controlling it. This study evaluated the anti-atherosclerotic effects of Aloe vera in hypercholesterolemic rabbits.

This experimental study was performed on 32 New Zealand male rabbits weighing 1800-2000 gr. Animal model of atherosclerosis was developed in 32 male rabbits using high-cholesterol diet (cholesterol 1%). Rabbits in four experimental groups (n=8) were treated for 30 days: normal diet group, high-cholesterol diet group, high-cholesterol diet group with Aloe vera gel (3.2%v/v per day in their drinking water), and Aloe vera with the normal diet group. At the beginning and end of study rabbits blood was used for total cholesterol, triglyceride, LDL, HDL, FBS measuring by enzymatic methods and CRP. The presence of fatty streaks in arteries of animals with histopathological methods was investigated and compared.

High cholesterol diet group was significantly increased total cholesterol and CRP (p<0.05). Results indicated that the use of Aloe vera in the third group with high-cholesterol diet significantly decreased total cholesterol (576.88±292.52 vs. 1059±79.11) and CRP in this group than high-cholesterol group (p<0.05). Other lipoproteins after studying in groups 2 and 3 compared with normal diet and Aloe vera alone had a significant increase (p<0.05), but they have not significant difference with each other. The use of Aloe vera along with high-cholesterol diet significantly reduced the formation of fatty streaks in the high-cholesterol group (p<0.05).

The results show that the consumption of Aloe vera by knowing the impact of cholesterol and inflammation as major risk factors for atherosclerosis can be beneficial effects in controlling this disease prevention.