sadra rohani

Brain tumors are rare and yet a significant cause of mortality and morbidity in adults. Surgical resection has been treatment of choice for brain tumors. Despite its effectiveness, surgical resection may cause various post-operatives complications such as infections, neurological deficits, and vascular damages that can lead to decrease in quality of life and survival rate and can impose great medical expenses. This study was aimed to assess related factors of medical and surgical complications after surgical brain tumors resection.

This was a descriptive and retrospective study performed on patients that underwent brain surgical tumor resection at Rasoul Akram Hospital of Iran University of medical science in Tehran, 2016. Age, sex, extent of resection, pathology of tumor, post-operative symptoms and complications, duration of surgery, blood loss volume during surgery, and duration of admission were collected, and analyzed with SPSS.

Of 179 patients, 47.5% (85) were male, and 52.5% (94) were female. Mean patient age was 45.8 years old, and mean admission duration was 4.6 day before and 9.7 day after surgery. The most common surgical complications were hydrocephalus (13.4%) and ICH (9.5%). The most common medical complication was electrolyte disorder (13.4%). Mean surgery duration was 1 hour 40 min and mean blood loss during surgery was 542 ml.

Based on our study, extent of brain resection was correlated with surgical and medical complications. Older age, longer duration of admission, and longer duration of surgery were correlated with medical complications, but it was not correlated with surgical complications. Older age was correlated with higher mortality rate. Blood loss volume during surgery had no correlation with surgical or medical complications.

Glucocerebrosidase (GBA) mutation is the most common genetic risk factor in Parkinson’s disease (PD). Transcranial sonography (TCS) shows increased substantia nigra (SN) echogenicity in both idiopathic and genetic forms of PD. The goal of this study was to compare maximal area of SN hyperechogenicity (aSNmax) and diameter of third ventricle (DTV) between GBA mutation carriers and healthy controls. Twenty-six carriers of GBA mutation and twenty-six healthy controls underwent TCS. The aSNmax and the DTV were measured. Mini-mental status examination (MMSE) and demographic data of the subjects were recorded, too. Mean aSNmax in GBA mutation carriers was significantly higher (0.31 ± 0.06 cm2) than controls (0.16 ± 0.04 cm2). Moreover, DTV was significantly higher in GBA mutation carriers group (3.98 ± 0.90 vs 3.29 ± 0.56 cm). Increased SN echogenicity and increased third ventricle diameter in GBA mutation carriers may be caused by alterations in iron metabolism with reference to their genetic status