فهرست مطالب saeid azimi

The G-protein receptor kinases are members of the most effective enzymes in the incidence of some important disease such as cardiovascular diseases, hypertension and Alzheimer’s disease. One of these enzymes is a protein with PDB code: 3v5w in the protein data bank. The in-silico study on the interaction of variety of inhibitor ligands with this enzyme was performed. The results of the interaction between selected ligands and target protein were investigated and analyzed using molecular screening by molecular docking simulation methods. The calculations of some factors such as binding energy between ligands and target protein, non-bonding interactions of ligands in the active site of enzyme and analysis of the result of molecular docking scoring were performed. The results were compared with a standard inhibitor (Paroxetine). Furthermore, to better evaluate and correct the selection of the lead compound, the related properties of absorption, distribution, metabolism, excretion and toxicity (ADMET) of high-scored ligands were compared with pharmacokinetic factors of Paroxetine using ADMETLab 2.0 data server platform. As the result, the compound L10, (4R,5S)-5-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one was introduced as a novel potent inhibitor ligand which has the better potency, more binding energy and more  appropriate pharmacokinetic properties.

In this research, at first, nanoporous zeolite-NaY was functionalized through reaction with 3-chloropropyltriethoxysilane (organic linker) and then with N-methylimidazole group. Then magnetic nanoparticles (Fe3O4) were formed and stabilized under ultrasonic energy conditions on the surface and internal pores of zeolite-Y (1-MeIm IL@ZY-Fe3O4). The structure of zeolite-ionic liquid prepared as a magnetic nanohybrid using the techniques of FTIR, FESEM, EDS, TGA, BET, XRD and VSM instrumental analyses were identified and confirmed. At the next step, its catalytic performance in the synthesis of a number of 4-aryl-2-amino benzopyran (chromene) or 4-aryl-2-amino naphthopyran (benzochromene) derivatives was investigated through the three-component condensation reaction of aromatic aldehydes, malononitrile and dimedone or β-naphthol, at ambient temperature and aqueous medium. The advantages of this method include the use of cheap, safe and reusable nanocatalyst, easy separation of the heterogeneous catalyst from the reaction medium with the using of a magnet, short reaction time, high yield, easy and fast separation of the product, and the use of non-toxic water solvent, that has made this method in simplicity, be in the scope of "green chemistry".

Acetyl Choline Esterase (AChE) is one of the most important enzymes in the process of Alzheimer's disease. Inhibition of acetyl choline metabolism using inhibition of AChE is partially successful in improving symptoms of Alzheimer's disease. In silico study and evaluation are applied through virtual screening tools such as molecular docking simulations and prediction of ADMET-related properties to investigate novel potent inhibitors of AChE. The molecular docking simulation is performed to achieve the best binding affinity and docking scores. This is done by comparison between the standard inhibitor and high-scoring selected ligands. After evaluation of Molecular docking results and ADMET-related properties, 2-[(1-benzylpiperidin-2-yl) methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one was indicated as novel potent AChE inhibitor.

Pseudomonas aeruginosa is the bacterium that causes of pulmonary infection among chronically hospitalized patients. Alginate is a common surface antigen of P. aeruginosa with a constant structure that which makes it an appropriate target for vaccines. In this study, P. aeruginosa alginate was conjugated with to PLGA nanoparticles, and its immunogenicity was characterized as a vaccine. Alginate was isolated from a mucoid strain of P. aeruginosa and conjugated with to PLGA with˝ N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ˝= ˝EDAC˝ and N-Hydroxysuccinimide (NHS). Chemical characterization of prepared nano-vaccine was performed using FTIR Spectroscopy, Zetasizer, and Atomic Force Microscopy (AFM). The immunogenicity of this nano-vaccine was evaluated through intramuscular injection into BALB/c mice.  Four groups of mice were subjected to the injection of alginate–PLGA, and two weeks after the last administration step, opsonophagocytosis assay, IgG detection, challenge, and cytokine determination via ELISA were carried out. Alginate-PLGA conjugation was corroborated by FTIR, Zetasizer, and AFM. The ELISA consequence showed that alginate was prospering in the instigation of the humoral immunity.The immunogenicity enhanced against the alginate-PLGA. Remarkably diminished bacterial titer in the spleen of the immunized mice posterior to challenge with PAO1 strain in comparison with the  alginate alone and control groups. The bacterial burden in the spleen significantly decreased after the challenge (p <0.05). The opsonic activity was significantly increased in the alginate- PLGA group (p <0.05).

Decreasing the quality of life in cancer patients is an essential factor that influences their lives during the process of treatment and after that. A lot of studies have been done to evaluate the efficacy of medical agents on quality of life. In this study, we evaluate the efficacy of Bupropion as an antidepressant agent in quality of life of cancer patients.

In this double-blind randomized placebo-controlled clinical trial, a total of 30 eligible cancer patients suffering from fatigue were randomly divided into two 15-individual groups of bupropion and placebo. Bupropion was administered 75 mg/day for the first three days and 150 mg/day (in two doses) till the end of the study for group bupropion. Quality of life was measured by EORCT-QLQ-C3 scale. Adverse effects were assessed based on NCI Common Terminology Criteria for Adverse Events. The study was six weeks long and assessments were done at baseline, second week and sixth week.

There was no significant difference in scores between placebo and bupropion at baseline and second week. While, significant difference was seen at the week six (P=0.005 for function, P=0.036 for symptoms and P<0.001 for health).  Between group assessments showed better average score for bupropion in comparison to placebo. Only two cases of adverse effects were reported.

bupropion can be effective in improvement of quality of life in cancer patients

In this study, the creep behaviors of composite panels used in library shelves were investigated. For this purpose, two types of wood-composite panels (medium density fiberboard and particleboard), and three types of covering including synthetic laminates, natural veneer, and without cove, and two types of wood joints (fixed and detachable) were used. Dimensions of the book-shelves were in actual shelf size, that is, 1,000 × 300 mm. Totally, 48 shelf specimens were prepared. For the creep test, a 23.5 kg loading level was applied in the center part of the shelves. Measurements on the creep behavior were carried out over 155 days at different intervals. Results indicated that the type of wood-composite as well as the type of veneer had statistically significant effect on the creep behaviors of panels. The lowest creep was observed in MDF panels. Moreover, those panels covered with natural veneer demonstrated significantly lower creep values. The type of joint also had a significant effect on the creeping behavior of the shelves, though not as conspicuous as the type of panels and veneers. Based on the results of the present research project, it is suggested that in order to increase the service life of library shelves it would be better to produce the shelves from MDF panels covered with natural veneers; these shelves should be fixed on supports.

Friedel–Crafts synthesis of triarylmethanes over 3-methyl-1-sulfonicacid imidazolium tetrachloroaluminate under green conditions:In this work, Friedel–Crafts (FC) alkylation of various arenes with aromatic aldehydes catalyzed by 3-methyl-1-sulfonic acid imidazoliumtetrachloroaluminate {[Msim]AlCl4}, as a green catalyst, to prepare triarylmethanes (TAMs) has been carried out. Some aromatic aldehydes were reacted with arenes containing electron-donor substitutions such as anisole, veratrole, phenols, indole and 2-naphtole under solvent-free conditions. The catalyst was recovered and reused successfully for four times. Simple methodology, easy work up, solvent-free condition and excellent yields are some advantages of this work.The promising points for the presented method are high yield, green reaction profile, easier work up and simplicity which make it a useful process for the preparation of various triarylmethanes