saeid heidari-soureshjani

 Breast cancer is one of the most prevalent cancers in women worldwide. Considering the side effects of chemotherapy treatments, we investigated the anticancer effects and mechanisms of bromelain (Br) on breast cancer cells in this systematic review.

 The PRISMA recommendations were followed to design this systematic review. Web of Science, PubMed, Cochrane Library, and Scopus were high-coverage databases used for searching. After considering the inclusion and exclusion criteria for the study, 18 articles were included. The desired information was gathered, entered into an Excel file, and the study outcomes were surveyed.

 Br revealed its anticancer effects by preventing the proliferation of cancer cells, inducing cytotoxicity, apoptosis, autophagy, and cellular oxidation in breast cancer cells. Moreover, its anti-inflammatory activity and immunomodulatory effects in the tumor environment can increase treatment outcomes. No significant side effects of this proteolytic substance have been reported, and it is a safe herbal constitution. Its combination with anticancer drugs such as cisplatin has revealed synergic effects. Besides reducing the toxicity of chemotherapy drugs, Br improves treatment outcomes.

 Br has shown promising anticancer effects against breast cancer in in vivo and in vitro studies. However, more clinical trial studies are needed to achieve more reliable results.

Obesity is a growing problem that causes various metabolic disorders and organ dysfunction. The present systematic review and meta-analysis examined the impact of obesity on the risk of kidney stones. This meta-analysis was designed according to PRISMA guidelines. This extensive search was conducted on June 6, 2022, using relevant keywords in databases including PubMed, Web of Science, EMBASE, and Scopus. The data collected from observational studies were recorded in a datasheet. Odds Ratio (OR) and their 95% confidence intervals (CI) evaluated the overall effect size. The Cochran Q test and the statistic I 2 were used to evaluate the heterogeneity of studies. Egger’s and Begg’s tests assessed potential publication bias. We included 15 observational studies published between 2005 to 2022 in this analysis. Compared to non- obese individuals, the OR for developing kidney stones in obese participants was 1.35 (95% CI: 1.20 to 1.52, P < .001). Considering geographical location, the OR for the risk of developing kidney stones in obese individuals was 1.51 (95% CI: 1.11 to 2.05, P = .009) in North America, 1.33 (95% CI: 1.16 to 1.51, P < .001) in Europe, and 1.18 (95% CI: 1.08 to 1.29, P < .001) in Asia. Begg’s test results (P = .625) demonstrated no publication bias. However, Egger’s test results (P = .005) indicated publication bias. Based on the results, obesity increases the risk of kidney stone development. Therefore, community health programs should be implemented to reduce the incidence of obesity and lower the risk of kidney stones.

Research anxiety and academic self-concept are among the factors that can be effective in improving the level of students’ capabilities in research in the field of medical education.

The present study was conducted to determine the relationship between research anxiety and academic self-concept in master’s and doctoral students of Shahrekord University of Medical Sciences.

This cross-sectional descriptive-analytical research was conducted on 102 graduate students of Shahrekord University of Medical Sciences in the master’s and doctoral degrees in 2019. Sampling was performed using a convenience method. The data collection tool included the Higgins Research Anxiety Inventory and the Academic Self-Concept Questionnaire (ASCQ). The data were analyzed by calculating the mean and standard deviation, the independent t-test, and the Pearson correlation coefficient in SPSS software.

In master’s students, research anxiety was inversely and significantly correlated with academic self-concept (r = -0.339, P = 0.002) and academic self-confidence (r = -0.425, P < 0.001). Also, academic self-concept was directly and significantly associated with academic self-confidence (r = 0.876, P < 0.001) and academic effort (r = 0.821, P < 0.001). In doctoral students, academic self-concept also showed a direct and significant association with academic self-confidence (r = 0.835, P < 0.001) and academic effort (r = -0.753, P < 0.001).

 Research anxiety was associated with academic self-concept in master’s students of Shahrekord University of Medical Sciences, but such a relationship was not found in doctoral students.

This study was designed to determine the association curcumin has on pro-inflammatory biomarkers in patients with chronic kidney disease (CKD (and in those receiving hemodialysis (HD).

This meta-analysis was undertaken following PRISMA guidelines. An extensive systematic review was undertaken until 10/11/2021 using PubMed, Web of Science (ISI), and Scopus databases. The standardized mean difference (SMD) and 95% confidence intervals (CI) were used to estimate the overall effect size of curcumin on serum high-sensitivity C-reactive protein (hs-CRP), and pro-inflammatory cytokines including interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in patients with CKD and those receiving HD.

Overall, ten randomized controlled trials (RCTs) comprising 523 patients were incorporated into the systematic review and meta-analysis. The results showed that when compared with control groups, there was no significant effect observed linking curcumin and IL-6 (SMD = 0.24%, 95% CI = -0.14 to 0.62, p = 0.221), TNF-α (SMD = 0.11%, 95% CI = -0.19 to 0.40, p = 0.480) or hs-CRP (SMD = -0.17%, 95% CI = -0.36 to 0.03, p = 0.093). The analysis determined no publication bias related to the influence of curcumin on IL-6, TNF-α or acute phase reactant, hs-CRP. The Egger’s and Begg’s test results were not statistically significant (p˃0.20).

In patients with CKD and those receiving HD, the use of curcumin supplementation has no statistically significant effect on the anti-inflammatory biomarkers reviewed in this study.

Foeniculum vulgare due to phytoestrogens is important in the treatment of female sexual dysfunction including infertility. Accordingly, this study was conducted to investigate the effect of the F. vulgare seed extract on the fertility results of assisted reproductive technology (ART) in women with a poor ovarian response (POR).

In this before-after intervention, 19 infertile women with POR were enrolled by a convenience sampling method. T h e amounts of luteinizing hormone ( LH) and follicle-stimulating hormone (FSH), ovarian ultrasound volume, the number of preantral follicles, and the size of the prominent ovary were measured before treatment with F. vulgare. Then, patients were treated with F. vulgare for two months, followed by initiating the in vitro fertilization (IVF) cycle. The number of embryos transferred in previous and current cycles was investigated after IVF. Finally, the data were analyzed in SPSS 16.

There was a significant difference in the serum LH level (P=0.002), LH/FSH (P=0.049), the number of follicles and ovules (P=0.003), endometrial thickness (P=0.04), and ovarian volume (P=0.03) between before and after treatment with F. vulgare. Moreover, a significant difference regarding the decreased number of required days for induction was observed between before and after treatment with F. vulgare (P=0.022).

In general, the use of F. vulgare had positive effects on improving t h e quality of oocytes and female fertility indices in women with POR

SelfSelf-efficacy refers to the degree of one's control over his/her ability to perform certain activities. Student's research self-efficacy represents their confidence in their own ability to conduct various research activities. This study was conducted to determine research self-efficacy components in postgraduate students.
In this descriptive-analytical cross-sectional study which has been done in 2015, 112 MSc students of Shahrekord University of Medical Sciences that were selected by census method participated. A two-section questionnaire including demographic characteristics (5 questions) and self-efficacy scales (55 questions) was distributed among students which examines the subscales of statistical and analytical self-efficacy, self-efficacy in the conceptualization, in method and run, in quality research, reporting, skills and ethics subscales. Collected data were analyzed by SPSS using independent t test, pearson correlation test, spearman and ANOVA tests.
The mean value of total research self-efficacy of the students was 155.93±29.06, and the total score for research self-efficacy and the scores for all of its components were within a moderate range. Implementing research project or collaborating with a project as colleague (in number) was the only variable to be directly correlated with self-efficacy (p The status of research self-efficacy and its components among the postgraduate students in this university is in the moderate range. The findings of this study demonstrated that students cooperation or collaboration in implementing research project is considerably effective in promoting research self-efficacy components among them.

impermanent and negative self-concept , disrupts personal and social adjustment. in this study compared self-concept and behavior in adolescents without a history of juvenile criminal and offenders.
The study was cross-sectional . 79 person from centers for Upbringing and correction via census sample and 120 person that with first group in regard to age-and sex- matched controls from Isfahan City were enrolled. The data collection instrument consisted of three sections include demographic information , self-concept and behavior questions. Statistic examination include T-test, Fisher and K2, were use for data analyzed .
The mean and standard deviation of self-Concept in offenders was 58/94±10/30 and Behavior was 62/26±28/81. Adolescents with no history of criminal record, self-concept score was 63/02±9/75 and Behavior was 84/66±15/22. Self-concept and behavior scores were significantly higher in the group with no criminal record (p The results suggest that the Self-concept and Behavior of juvenile offenders is lower than adolescents with no criminal record. It is also considered demographic factors will affect the incidence of antisocial behavior . It seems psychologists and counselors to be working in these centers must training , counseling and therapy and correction techniques with consideration to the establishment of such anomalies .