sajjad hussain sumrra
-
Iranian Journal of Chemistry and Chemical Engineering, Volume:40 Issue: 5, Sep-Oct 2021, PP 1630 -1641
The new biologically active integrisides A (1) and B (2) have been isolated from the methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis. The antibacterial activity of both the integrities was tested against four pathogenic bacterial strains, two Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) as well as four fungal strains (Microsporum canis, Aspergillus clavatus, Candida albicans, and Candida glabrata). Both the isolated compounds showed significant results analogous with Imipenam and Miconazole standard drugs. Carbonic anhydrase-II inhibition of integriside A (1) and B (2) with IC50 value 1.56 µM and 2.85 µM respectively, as compared to standard drug acetazolamide (1.57 µM). Cholinesterase activity was carried out with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) IC50 values of integriside A (1) (8.6, 4.8) and B (2) (0.91, 2.5) were found as compared with standard galanthamine (0.05, 0.92) and Eserine (0.6, 8.7). Here, various molecular descriptors, frontier molecular orbitals (FMO), electron affinity (E.A), ionization potential (IP), molecular electrostatic potential (MEP), and Hirshfeld analysis were carried out to understand the active sites and biological active nature of the integrisides A (1) and B (2). The energy gap, MEP, Hirshfeld analysis, and reactivity descriptors values demonstrate that the integriside A (1) and B (2) retain decent reactivity, which is in good agreement with current experimental and quantum chemical studies.
Keywords: Pistacia integerrima J. L. Stewart ex Brandis, Integrisides, Cholinesterase activity, Antimicrobial activity, Quantum chemical study
- در این صفحه نام مورد نظر در اسامی نویسندگان مقالات جستجو میشود. ممکن است نتایج شامل مطالب نویسندگان هم نام و حتی در رشتههای مختلف باشد.
- همه مقالات ترجمه فارسی یا انگلیسی ندارند پس ممکن است مقالاتی باشند که نام نویسنده مورد نظر شما به صورت معادل فارسی یا انگلیسی آن درج شده باشد. در صفحه جستجوی پیشرفته میتوانید همزمان نام فارسی و انگلیسی نویسنده را درج نمایید.
- در صورتی که میخواهید جستجو را با شرایط متفاوت تکرار کنید به صفحه جستجوی پیشرفته مطالب نشریات مراجعه کنید.