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فهرست مطالب samira khayat

  • Samira Khayat, Maryam Navaee, Hamed Fanaei, Farnoosh Khojasteh
    Background

    Waterpipe smoking is associated with maternal and fetal complications, and valid data contribute to evidence‑based planning. This study was conducted to determine the prevalence and factors related with waterpipe smoking among pregnant women of Zahedan city in 2020.

    Methods

    This cross‑sectional study was conducted in 2020, and 400 pregnant women in the third trimester of pregnancy who lived in Zahedan participated in it by single stage randomized cluster sampling. A questionnaire was used to measure awareness of waterpipe complications, and another one investigated the status of waterpipe smoking to collect data. For data analysis, descriptive statistics and multiple logistic regression were used through SPSS 21.

    Results

    The findings indicated that the prevalence of waterpipe smoking was 18.8%. In the waterpipe smoking group, 46.6% smoked every day, 89.3% had tried to reduce the smoking, and 64.8% reported fetal death as their main motivation to reduce smoking. Only 5.6% of subjects stated receiving training as the reason for reduction of their waterpipe smoking. The women’s level of education, economic status, ethnicity, and awareness of the risks of waterpipe smoking were the predictors for waterpipe smoking (P < 0.05, P = 0.03, P = 0.006, and P < 0.001, respectively).

    Conclusions

    The results of this study show the high prevalence of waterpipe smoking in pregnant women of Zahedan. Further investigation and training in this regard are essential for pregnancy as well as pre‑pregnancy care. Special attention should be paid to groups with better economic status and level of education, Baluch women, and those with low level of awareness.

    Keywords: Iran, pregnancy, prevalence, tobacco, waterpipe smoking}
  • Samira Khayat, Maryam Palizvan, Ali Navidian, Hamed Fanaei, Zahra Pahlavani Sheikhi
    BACKGROUND

    Improving self‑care in adolescent pregnancy leads to improved maternal and neonatal outcomes of pregnancy. However, self‑care in adolescent pregnancy is less than other women. The aim of this study was to compare the effect of face‑to‑face training and telemedicine on self‑care in adolescent pregnant women.

    MATERIALS AND METHODS

    The present study is a quasi‑experimental study that was conducted in Zahedan in 2021 and 120 adolescent pregnant women with a gestational age of 15–20 weeks participated in it. The sampling was done in multistage, and the samples were divided into three groups: Face‑to‑face training, telemedicine, and control. Face‑to‑face training was presented in five sessions and the telemedicine group received the similar educational content through the mobile applications. The samples completed a researcher‑made self‑care questionnaire before the intervention and at 28 weeks of gestation. SPSS software version 21 was used for the analysis, and data were analyzed by ANOVA, Tukey post hoc, Kruskal–Wallis, and Mann–Whitney tests.

    RESULTS

    There was no significant difference in face‑to‑face and telemedicine training in improving the scores of nutritional performance, smoking and narcotics use, personal hygiene, and routine pregnancy care (P > 0.05), but face‑to‑face training caused more improvement in the scores of sports and physical activity as compared to telemedicine group (P = 0.04). Face‑to‑face training and telemedicine training in all domains led to a significant improvement in scores as compared to the control group (P < 0.05).

    CONCLUSION

    The results of this study showed that the face‑to‑face training and telemedicine methods were proper methods for self‑care education in pregnant adolescent women. It is recommended to use these methods in promoting self‑care in pregnant adolescent women.

    Keywords: Adolescent, education, pregnancy, self‑care, telemedicine}
  • Farnoosh Khojasteh, Mahdie Afrashte, Samira Khayat, Ali Navidian
    BACKGROUND

    Fear of childbirth is a common problem during pregnancy, which can give rise to sleep disorders and diminish sleep quality. This study aimed to determine the effect of cognitive– behavioral training on fear of childbirth and sleep quality of pregnant adolescent slum dwellers who visited the slum health centers of Zahedan city, Iran, in 2020.

    MATERIALS AND METHODS

    This quasi‑experimental study was conducted in 2020 on 100 pregnant adolescent slum dwellers between 11 and 19 years old at 24–28 weeks pregnant. Multi‑stage sampling was used and the participants were randomly divided into an intervention and a control group. The intervention group received four sessions of cognitive–behavioral training at weekly intervals. The control group only received routine care. The Wijma Delivery Expectancy/Experience Questionnaire and the Pittsburgh Sleep Quality Index were filled before and 4 weeks after the training course. The data were analyzed in SPSS 21 using independent t‑test, paired t‑test, Fisher’s exact test, and Chi‑squared test. and covariance. A P value of < 0.05 was considered significant.

    RESULTS

    After the intervention, the fear of childbirth significantly decreased (P = 0.004), and sleep quality significantly improved (P = 0.001) in the intervention group compared with the control group. The results of analysis of covariance to control the significant effect of pre‑test scores showed that the mean score of fear of childbirth (P = 0.03) and mean score of sleep quality (P = 0.001) in the two groups after the intervention was statistically significant.

    CONCLUSION

    The results showed that in addition to reducing fear of childbirth, cognitive–behavioral training improved the sleep quality of women in the intervention group. Therefore, this training could be used as an easy and accessible method without complications to improve women’s health.

    Keywords: Adolescent pregnancy, childbirth fear, cognitive–behavioral therapy, sleep quality, slum}
  • Motahhare Hashemzahi, Samira Khayat *, Somayeh Khazayan
    Background & aim

    The coronavirus pandemic has increased stress and anxiety among pregnant women and established barriers to in-person care around the world. Accordingly, the purpose of this study was to determine the effect of COVID-19 self-care training via telemedicine on perceived stress and corona disease anxiety in pregnant women.

    Methods

    The present quasi-experimental study was conducted on 100 pregnant women who referred to comprehensive health centers in Zahedan, Iran between June and September 2021. The sample was randomly assigned into two groups of 50 subjects. The intervention group received the educational content via WhatsApp Messenger in six sessions. Data collection tools were Perceived Stress Scale (PSS) and Corona Disease Anxiety Scale (CDAS). The self-administered questionnaires were completed before the intervention and one month after the training program.

    Results

    After the intervention, mean PSS score in the intervention group (25.34±6.63) was significantly reduced compared to the control group (28.42±5.75) (p=0.015). Also, mean CDAS score in the intervention group (13.14±7.29) had a significant decrease compared to the control group (20.54±6.67) (P<0.001).

    Conclusion

    The results of our study confirmed the effectiveness of COVID-19 self-care training via telemedicine in reducing the perceived stress and anxiety of pregnant women during the coronavirus pandemic. Therefore, the use of this method in the care of pregnant women is recommended to mitigate stress and anxiety.

    Keywords: self-care, COVID-19, Telemedicine, Perceived stress, Anxiety, pregnancy}
  • Zahra Sheibani Matin, Samira Khayat, Ali Navidian, Hamed Fanaei
    INTRODUCTION

    Many women refuse to exercise during pregnancy due to lack of awareness and not receiving training. The aim of this study was to investigate and compare the effect of group and telemedicine education on exercise during pregnancy by using the health belief model (HBM).

    MATERIALS AND METHODS

    This quasi-experimental study was carried out in 2019 in Zahedan, and a total of 135 pregnant women participated in it. Samples were randomly assigned to the following three groups: group training (n = 45), telemedicine (n = 45), and control (n = 45). Group training was presented in three sessions, and the telemedicine group received the educational content through mobile applications. The samples completed the HBM questionnaire before and 6 weeks after the intervention. In addition, within 6 weeks after the intervention, they completed the exercise activity schedule. SPSS software Ver. 16 (IBM Corp, Armonk, NY, USA) was used for analysis, and data were analyzed by ANOVA, Tukey’s post-hoc test, Kruskal–Wallis test, and Mann–Whitney test.

    RESULTS

    After intervention, the scores of HBM constructs and exercise levels in group training, telemedicine group, and control group, respectively, were as follows: perceived susceptibility 25.91 ± 3.24, 25.51 ± 1.97, and 22.55 ± 3.78; perceived severity 27.48 ± 2.27, 25.13 ± 2.29, and 22.51 ± 3.88; perceived benefits 27.28 ± 2.97, 25.68 ± 3, and 22.8 ± 3.05; perceived barriers 10.69 ± 2.69, 10.66 ± 3.19, and 14.17 ± 3.14; cues to action 24.71 ± 4.35, 23.9 ± 2.48, and 22.84 ± 3.02; self-efficacy 26.17 ± 3.05, 25.2 ± 2.82, and 22.51 ± 3.38; and exercise levels 70.99 ± 20.43, 56.51 ± 21.99, and 37.62 ± 29.66. Group training and telemedicine led to significant improvement in all HBM constructs and exercise levels (P < 0.05, P < 0.0001, and P = 0.003, respectively). Group training provided more improvement than telemedicine in the scores of perceived severity (P < 0.0001), perceived benefits (P = 0.001), cues to action (P = 0.02), and mean exercise time (P = 0.001).

    CONCLUSION

    The results of this study showed that the HBM is a proper model for exercise education in pregnant women. It is recommended to use HBM as a group training and telehealth in promoting the rate of exercise in pregnant women.

    Keywords: Educational, exercise, models, pregnancy, telemedicine}
  • Samira Khayat *, Mahrokh Dolatian, Hamed Fanaei, Ali Navidian, Zohreh Mahmoodi, Amir Kasaeian
    Background & aim

    Reproductive health has been documented as international human rights. In this respect, residing in slums can lead to poor reproductive health status due to reduced access to healthcare services. Therefore, the present study was conducted to determine women’s reproductive health status in urban slums in southeast Iran.

    Methods

    In this cross-sectional study, a total number of 400 married slum-dwelling women in southeastern Iran were selected through random sampling in 2017. The inclusion criteria were marriage, residence in slum areas, and age group of 15-49 years. To collect the data, the Reproductive Health Needs Assessment questionnaire was completed using face-to-face interviews. Descriptive statistics were employed to analyze the data using SPSS software (version 19).

    Results

    67.8% of sample were women who were married before the age of 18. Also 36% of the subjects had more than four children, and 79.9% of them experienced an inter-pregnancy interval of less than 3 years. Moreover, 96.8% of the participants received prenatal care services, and 81% of the individuals used family planning methods. Unintended pregnancies experienced by 26% of the subjects, and 59% of them suffered from reproductive tract infections within the last year. The prevalence rate of sexual and physical violence were 40% and 20.5%, respectively.

    Conclusion

    Although the coverage of prenatal, childbirth, and family planning services was appropriate in this region, the domains of family planning, physical and sexual violence, as well as marriage age in women living in urban slums, were undesirable and required more efforts to be improved by reproductive health professionals.

    Keywords: Reproductive Health Prenatal Care, Family Planning Services, Suburban Population, Poverty area}
  • سمیرا خیاط، حامد فنایی *، معصومه خیرخواه، معصومه پورمحسن
    پیش زمینه و هدف
    سندرم قبل از قاعدگی را اغلب زنان در سنین باروری تجربه می کنند. این سندرم ترکیبی از تغییرات خلقی، جسمی و رفتاری است که با ارتباطات خانوادگی و فعالیت های اجتماعی تداخل می کند. روش های مختلفی برای درمان این سندرم مطرح شده و یکی از این روش ها استفاده از گیاهان دارویی است. این مطالعه باهدف تعیین تاثیر کورکومین بر شدت علائم سندرم قبل از قاعدگی انجام شد.
    مواد و روش کار
    در این کارآزمایی بالینی دو سو کور، 70 نفر از دانشجویان دارای علائم PMS به صورت تصادفی به دو گروه دریافت کننده کورکومین و دارونما تقسیم شدند. مبتلایان روزانه دو کپسول از هفت روز قبل از قاعدگی تا 3 روز پس از قاعدگی به مدت 3 سیکل دریافت کردند و پرسشنامه ثبت علائم روزانه تکمیل شد. داده های قبل از مداخله و 1، 2 و 3 سیکل پس از مداخله توسط آزمون های آنالیز واریانس اندازه گیری های مکرر و تی مستقل تجزیه وتحلیل شدند. جهت تجزیه وتحلیل از نرم افزار 18–SPSS استفاده شد و P<0/05 معنی دار تلقی شد.
    یافته ها
    قبل از مداخله دو گروه ازنظر میانگین امتیازات علائم PMS تفاوت معنی دار آماری نداشتند (گروه کورکومین39/1±103/6 و گروه دارونما 44/6±106/7 و P=0/77)؛ اما پس 1، 2 و 3 سیکل مداخله تفاوت میانگین امتیازات علائم PMS بین گروه ها معنی دار بود (در گروه دارونما به ترتیب 40/13±93/72،49/13±91/36 و 50/49±91/45 بود و در گروه کورکومین به ترتیب 22/6±53/5،19/1±42/1 و6/11±7/29) (P<0/0001).
    بحث و نتیجه گیری
    کورکومین در کاهش شدت علائم خلقی، رفتاری و جسمانی سندرم قبل از قاعدگی موثر است و استفاده از آن در درمان این سندرم پیشنهاد می شود.
    کلید واژگان: سندرم قبل از قاعدگی, کورکومین, طب مکمل}
    Samira Khayat, Hamed Fanaei *, Masoomeh Kheirkhah, Masoumeh Pourmohsen
    Background and Aims
    Most women experience the premenstrual syndrome at their reproductive ages. This syndrome is a combination of psychological, physical In this double-blind clinical trial, 70 students with PMS were randomly assigned to either the curcumin or placebo groups. Each participant received two capsules daily from seven days before menstruation to three days after menstruation for three cycles. They recorded severity of the symptoms by daily record questionnaire. The data of before interventions, and 1, 2 and 3 months after interventions and P
    Results
    Before intervention, there were no significant differences between the mean scores of PMS symptoms in the two groups (103.6 ±39.19 in curcumin group VS 106(.
    Conclusion
    Based on results of this study, curcumin is effective in reduction of severity of psychological, physical and behavioral symptoms of PMS, and we suggest curcumin as treatment for PMS.
    Keywords: Premenstrual syndrome, curcumin, Complementary Therapies}
  • سمیرا خیاط، معصومه خیرخواه، حامد فنایی *، زهرا بهبودی مقدم، معصومه پورمحسن، امیر کساییان
    زمینه
    اغلب زنان در سنین باروری سندرم قبل از قاعدگی (PMS) را تجربه می کنند. روش های مختلفی برای درمان این سندرم مطرح شده و مصرف گیاهان دارویی یکی از این روش ها است. این مطالعه با هدف تعیین تاثیر زنجبیل و کورکومین بر شدت علایم سندرم قبل از قاعدگی انجام شد.
    مواد و روش ها
    در این کارآزمایی بالینی دو سو کور، 105 نفر از دانشجویان دارای علایم PMS به صورت تصادفی به گروه های دریافت کننده زنجبیل، کورکومین و دارونما تقسیم شدند. شرکت کنندگان از هفت روز قبل از قاعدگی تا 3 روز پس از قاعدگی به مدت 3 سیکل، روزانه دو کپسول دریافت کردند و شدت علایم خود را توسط پرسشنامه ثبت روزانه شدت مشکلات (DRSP)، ثبت نمودند. داده های قبل از مداخله و 1، 2 و 3 ماه پس از مداخله توسط آزمون های آنالیز واریانس اندازه گیری های مکرر و تی مستقل تجزیه و تحلیل شدند. جهت تجزیه و تحلیل از نرم افزار SPSS ویرایش 18 استفاده شد و (05/0>P) معنی دار تلقی شد.
    یافته ها
    میانگین شدت علایم سندرم قبل از قاعدگی قبل از مداخله در سه گروه مشابه بود](7/30±2/110 در گروه زنجبیل، 1/39±6/103 در گروه کورکومین و 65/44±7/106 در گروه دارونما)79/0=[P، اما پس از مداخلات تفاوت های معنی داری بین گروه ها وجود داشت](4/33± 06/47 در گروه زنجبیل، 6/11±74/29 در گروه کورکومین و 7/48±106 در گروه دارونما) 0001/0[P˂. همچنین تفاوت معنی دار بین اثرات زنجبیل و کورکومین وجود داشت (008/0P=).
    نتیجه گیری
    زنجبیل و کورکومین در کاهش شدت علایم خلقی، جسمانی و رفتاری سندرم قبل از قاعدگی موثرند و اثر کورکومین بیشتر از زنجبیل است. نتایج مطالعه حاضر زنجبیل و کورکومین را به عنوان درمان سندرم قبل از قاعدگی پیشنهاد می کند.
    کلید واژگان: سندرم قبل از قاعدگی, زنجبیل, کورکومین, علایم خلقی, علایم جسمی, علایم رفتاری}
    Samira Khayat, Masoomeh Kheirkhah, Hamed Fanaei, Zahra Behboodi Moghadam, Masoomeh Pourmohsen, Amir Kasaeiyan
    Background
    Most women at reproductive ages experience the premenstrual syndrome (PMS). Different methods have been suggested for the treatment of this syndrome and one of them is using herbal medicine. This study was carried out to evaluate the effects of ginger and curcumin on severity of symptoms of PMS.
    Materials And Methods
    In this double-blind clinical trial, 105 students with PMS symptoms were randomly assigned to ginger, curcumin and placebo groups. Participants received two capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded severity of the symptoms by Daily Record of Severity of Problems (DRSP) questionnaire. Data of before interventions and 1, 2 and 3 months after interventions were analyzed by repeated measurement ANOVA and indepented t-test. SPSS-18 software was used for analyses and P<0/05 was considered significant.
    Results
    The mean of PMS symptoms severity were similar in three groups before the intervention [(110/2±30/7 in ginger group, 103/6±39/1 in curcumin group and106/7±44/65 in placebo group) p=0/79], but after interventions there were significant differences between groups [(47/06 ±33/4 in ginger group, 29/74±11/6 in curcumin group and106±48/7 in placebo group) P<0/0001]. Also, there was a significant difference between effects of curcumin and ginger (P=0/008).
    Conclusion
    Ginger and curcumin are effective in reduction of severity of psychological, physical and behavioral symptoms of PMS and the effect of curcumin is more than ginger. Results of present study suggest curcumin and ginger as treatment for PMS.
    Keywords: Premenstrual Syndrome, Ginger, Curcumin, Psychological symptoms, Physical symptoms, Behavioral symptoms}
  • Farin Soleimani, Ali Khakshour, Zohreh Abbasi, Samira Khayat, Seyede Zahra Ghaemi, Nayereh Azam Hajikhani Golchin
    Background
    Autism is a neurodevelopmental disorder that onset in the first 3 years of life and led to lifelong disability. Despite the early onset of symptoms, diagnosis of thissyndromedoes not happenuntil severalyears later, somany childrenlosethe opportunityfor earlyintervention. There arevarious toolsforscreening anddiagnosis, buttheirdesign, strengths and weaknesses aredifferent. The aim of this study was assess these tools from various aspects to provide a comprehensive view.
    Materials And Methods
    This study is a narrative literature review on screeningtoolsof autism. Comprehensive searches of the scientific literature were conducted in textbooks and 8 electronic databases (proquest, wiley, google scholar, SID, Scopus, Web of Science، Science Direct، and Medline) and Pediatric book. language restriction (Persian and English) was applied. The search strategy consisted of keywords and medical subject headings for autism and various screening tests.
    Result
    In this study, 28 screening tests were identified from 1992 to 2014. CHAT is oldest test and the most recent test is CAST The minimum age that can perform the screening is six months that related to ITC. Minimum time of testing was 5 minutes for CHAT and the maximum time was 90-120 minutes for ASIEP-3. RAADS-R test was the highest specificity and specificity (100%) and the lowest specificity was 14% in ESAT test
    Conclusion
    The results of this study indicate that any of the autism screening tools consider specific skill and various aspects of the disease, careful evaluation is need to choose proper test.
    Keywords: Autism, Child, Pervasive developmental disorder, Screening test}
  • سمیرا خیاط، معصومه خیرخواه*، زهرا بهبودی، حامد فنایی، امیر کساییان
    زمینه و هدف
    سندرم قبل از قاعدگی (Premenstrual syndrome یا PMS) اختلال شایعی در زنان سنین باروری می باشد. با توجه به عدم شناخت اتیولوژی دقیق این سندرم، درمان های متعددی برای آن پیشنهاد شده است. یکی از روش های درمانی، استفاده از گیاهان دارویی است. مطالعه حاضر با هدف تعیین تاثیر زنجبیل بر شدت علایم سندرم قبل از قاعدگی طراحی شد.
    مواد و روش ها
    در این کارآزمایی بالینی دو سوکور، 70 نفر از دانشجویان دختر دانشگاه علوم پزشکی تهران در سال 1392 که به PMS مبتلا بودند، به صورت تصادفی به گروه های دریافت کننده زنجبیل و دارونما تقسیم شدند. شرکت کنندگان از هفت روز قبل از قاعدگی تا سه روز پس از قاعدگی به مدت سه دوره، روزانه دو کپسول دریافت کردند و شدت علایم خود را ثبت نمودند. ابزار جمع آوری اطلاعات، فرم اطلاعات دموگرافیک و پرسش نامه ثبت روزانه شدت علایم بود. داده ها قبل از مداخله و 1، 2 و 3 ماه پس از مداخله توسط آزمون های آنالیز واریانس اندازه گیری های مکرر و تی مستقل تجزیه و تحلیل شد. نرم افزار SPSS نسخه 18 جهت تجزیه و تحلیل داده ها مورد استفاده قرار گرفت و 05/0 > P به عنوان سطح معنی داری در نظر گرفته شد.
    یافته ها
    میانگین امتیاز علایم PMS دو گروه قبل از مداخله (77/30 ± 2/110 در گروه زنجبیل و 65/44 ± 7/ 106 در گروه دارونما) تفاوت معنی داری نداشت (710/0 = P)، اما در میانگین شدت علایم PMS دو گروه 1، 2 و 3 ماه پس از مداخله (به ترتیب 76/45 ± 7/105، 68/50 ± 2/107 و 74/48 ± 0/106 در گروه دارونما و 76/32 ± 18/51، 12/33 ± 48/49 و 41/33 ± 06/47 در گروه زنجبیل) تفاوت های معنی داری مشاهده شد (001/0 > P).
    نتیجه گیری
    با توجه به نتایج این مطالعه، احتمال دارد زنجبیل در کاهش شدت علایم خلقی، جسمانی و رفتاری سندرم قبل از قاعدگی موثر باشد، البته کاربرد درمانی این دارو نیاز به مطالعات بیشتری دارد.
    کلید واژگان: سندرم قبل از قاعدگی, زنجبیل, طب گیاهی, طب مکمل}
    Samira Khayat, Masoomeh Kheirkhah *, Zahra Behboodi Moghdam, Hamed Fanaei, Amir Kasaeiyan
    Background And Objective
    Premenstrual syndrome (PMS) is a common disorder in women of reproductive ages. Regarding the unknown etiology of this syndrome، several treatments are recommended; one of them is use of medicinal herbs. This study was carried out to evaluate the effects of Ginger on severity of symptoms of premenstrual syndrome.
    Materials And Method
    In this double-blind clinical trial study، 70 students from Tehran University of Medical Sciences، Iran، which suffered from premenstrual syndrome were randomly assigned to Ginger and placebo groups in 2013. Participants received two capsules daily from seven days before menstruation to three days after it for three cycles and they recorded severity of their symptoms. Demographic information form and daily record of symptoms questionnaire were data collection tools. Data of before interventions and 1، 2 and 3 months after it were analyzed using repeated-measurement analysis of variances and indepented t tests via SPSS18 software. P < 0. 05 was considered significant.
    Results
    Before intervention، there were no significant difference (P = 0. 710) between the mean scores of symptoms of premenstrual syndrome in the two groups (110. 20 ± 30/77 in Ginger and 106. 70 ± 44. 65 in placebo groups). But at 1، 2 and 3 months after intervention، there were significant differences (P < 0. 001(between the mean scores of symptoms of premenstrual syndrome in the two groups (105. 70 ± 45. 76، 107. 20 ± 50. 68 and 106. 00 ± 48. 74 in placebo، and 51. 18 ± 32. 76، 49. 48 ± 33. 12، and 47. 06 ± 33. 41 in Ginger groups، respectively).
    Conclusion
    Based on results of this study، Ginger may be effective in reduction of severity of psychological، physical and behavioral symptoms of premenstrual syndrome. However، therapeutic use of these drugs needs further studies.
    Keywords: Premenstrual syndrome, Ginger, herbal medicine, complementary therapies}
  • حامد فنایی*، سمیرا خیاط، ایمان حلوایی، وحید رمضانی، یاسر عزیزی، امیر کساییان، جلال مردانه، محمدرضا پرویزی، مریم اکرمی
    مقدمه
    استرس اکسیداتیو در نمونه های منی اسپرم تراتو منجر به کسب نتایج ضعیف توسط روش های کمک باروری می شود. در میان آنتی اکسیدان ها، اسید آسکوربیک خنثی کننده طبیعی رادیکال های آزاد است و با حضور خود نیز به مکانیسم های دیگر درگیر در کاهش فرآیندهای متعدد مخرب رادیکال های آزاد کمک می کند.
    هدف
    هدف اصلی از انجام این مطالعه ارزیابی اثرات محافظتی اضافه کردن اسید آسکوربیک بر نتایج کشت برون تنی نمونه های اسپرم تراتو بود.
    مواد و روش ها
    نمونه های منی حاوی اسپرم های تراتو از 15 نفر داوطلب تهیه، پردازش و سانتریفیوژ شدند و در دمای 37 درجه سلسیوس تا جهت شناور شدن اسپرم ها انکوبه شدند. اسپرم شناور به چهار گروه تقسیم و به مدت یک ساعت در انکوباتور تحت شرایط مختلف انکوبه گردید: گروه کنترل، گروه 10 میکرومول A23187، گروه 600 میکرومول اسید آسکوربیک و گروه 10 میکرومول A23187 + 600 میکرومول اسید آسکوربیک. پس از انکوباسیون تحرک، قابلیت بقاء، واکنش آکروزومی، آسیب DNA اسپرم و سطوح مالون دی آلدئید ارزیابی شدند.
    نتایج
    نتایج ما نشان داد پس از یک ساعت انکوباسیون اسید آسکوربیک به طور معنی داری سطح مالون دی آلدئید را در گروه اسید آسکوربیک (nmol/ml 1.4±0.11) در مقایسه با گروه کنترل (nmol/ml1.58±0.13) (p<0.001) کاهش داد. در انتهای انکوباسیون حرک پیشرونده و قابلیت بقاء در گروه اسید آسکوربیک(به ترتیب 64.5±8.8% و 80.3±6.4%) به طور معنی داری (به ترتیب 0/05>p و 0/001>p) بیشتر از گروه کنترل (به ترتیب %54.5±6.8 و %70.9±7.3) بود. A23187 به طور معنی داری (0/001
    نتیجه گیری
    افزودن اسید آسکوربیک به نمونه های منی حاوی اسپرم های تراتو حین آماده کردن اسپرم جهت استفاده در روش های کمک باروری می تواند منجر به حفاظت سلول های اسپرم در برابر استرس اکسیداتیو شود و احتمالا منجر به بهبود نتایج درمان این بیماران گردد.
    کلید واژگان: اسید آسکوربیک, اسپرم تراتو, واکنش آکروزومی, قطعه قطعه شدن DNA}
    Hamed Fanaei*, Samira Khayat, Iman Halvaei, Vahid Ramezani, Yaser Azizi, Amir Kasaeian, Jalal Mardaneh, Mohammad Reza Parvizi, Maryam Akrami
    Background
    Oxidative stress in teratozoospermic semen samples caused poorassisted reproductive techniques (ART) outcomes. Among antioxidants, ascorbicacid is a naturally occurring free radical scavenger and as such its presence assistsvarious other mechanisms in decreasing numerous disruptive free radical processes.
    Objective
    The main goal of this study was to evaluate potential protective effects of ascorbic acid supplementation during in vitro culture of teratozoospermic specimens.
    Materials And Methods
    Teratozoospermic semen samples that collected from 15 volunteers were processed, centrifuged and incubated at 37PoPC until sperm swimmed-up. Supernatant was divided into four groups and incubated at 37PoPC for one hour under different experimental conditions: Control, 10 μm A23187, 600μm ascorbic acid and 10 μm A23187+600 μm ascorbic acid. After incubation sperm motility, viability, acrosome reaction, DNA damage and malondialdehyde levels were evaluated.
    Results
    Our results indicated that after one hour incubation, ascorbic acid significantly reduced malondialdehyde level in ascorbic acid group (1.4±0.11 nmol/ml) compared to control group (1.58±0.13 nmol/ml) (p<0.001). At the end of incubation, progressive motility and viability in ascorbic acid group (64.5±8.8% and 80.3±6.4%, respectively) were significantly (p<0.05 and p<0.001, respectively) higher than the control group (54.5±6.8% and 70.9±7.3%, respectively). A23187 significantly (p<0.0001) increased acrosome reaction in A23187 group (37.3±5.6%) compared to control group (8.5±3.2%) and this effect of A23187 attenuated by ascorbic acid in ascorbic acid+A23187 group (17.2±4.4%). DNA fragmentation in ascorbic acid group (20±4.1%) was significantly (p<0.001) lower than controls (28.9±4.6%).
    Conclusion
    In vitro ascorbic acid supplementation during teratozoospermic semenprocessing for ART could protect teratozoospermic specimens against oxidativestress, and it could improve ART outcome.
    Keywords: Ascorbic acid, Teratozoospermic sperm, Acrosome reaction, DNA fragmentation, Oxidative stress}
  • حامد فنایی، یاسر عزیزی، سمیرا خیاط
    مطالعات اخیر نشان داده اند که گونه های واکنشی اکسیژن در شرایط فیزیولوژیک نقش بسیار مهمی در فرآیندهای پیام رسانی داخل سلولی دارند. از طرف دیگر، طی دهه اخیر مشخص شده گونه های واکنشی اکسیژن در ایجاد بخش عمده ای از انواع ناباروری های مردان نقش دارند و علت آن تولید بیش از حد گونه-های واکنشی اکسیژن یا کاهش توانایی سیستم آنتی اکسیدانی دستگاه تناسلی و اسپرم می باشد. گونه های واکنشی اکسیژن، در شرایط پاتولوژیک، از طریق اختلال در فرآیند اسپرماتوژنز، عملکردها و ساختار اسپرم (تحرک، قابلیت بقاء، واکنش آکروزومی، اتصال اسپرم به تخمک، آسیب DNA و غشا) و حتی کاهش شانش لقاح و لانه گزینی منجر به ناباروری می شود. دانستن نحوه اثرگذاری گونه های واکنشی اکسیژن بر فرآیندهای فیزیولوژیک سیستم تولید مثل نقش مهمی در درمان ناباروری دارد. بنابراین در این مقاله مروری در مورد یافته های آزمایشگاهی و بالینی اثرات گونه های واکنشی اکسیژن بر توانایی باروری بحث خواهیم نمود.
    کلید واژگان: گونه های واکنشی اکسیژن, آنتی اکسیدان, اسپرم, ناباروری مردان}
    Hamed Fanaei, Yaser Azizi, Samira Khayat
    Recent studies have shown that reactive oxygen species (ROS) have a very important role in the intracellular signaling process in physiological conditions. On the other hand، during the recent decade it has been indicated that ROS play a role in various types of male infertility and it is due to the overproduction of ROS or decrease in the antioxidant defense system in the reproductive system and sperm. In pathological conditions، ROS via interferences in the spermatogenesis process، sperm function، and sperm structure (motility، viability، acrosome reaction، sperm-oocyte fusion، and damage to DNA and cell membrane) as well as reduction in fertilization and implantation can lead to infertility. Knowledge of how ROS affect the physiological process of the reproductive system is crucial in the treatment of infertility. Thus، in this review article we will discuss experimental and clinical findings related to the effects of ROS on male fertility.
    Keywords: reactive oxygen species, antioxidant, sperm, male infertility}
  • حامد فنایی، جلال مردانه، سمیرا خیاط
    ناباروری مردان از اثرات مهم و برجسته عفونت های باکتریایی مجاری ادراری - تناسلی است. عفونت باکتریایی مجاری ادراری-تناسلی مردان سبب اختلال در فرآیند اسپرماتوژنز، عملکردها، ساختار اسپرم (تحرک، قابلیت بقاء، واکنش آکروزومی، اتصال اسپرم به تخمک، آسیب به DNA و غشاء اسپرم) و حتی انسداد مجاری تناسلی می شودو ناباروری یا کاهش سطح باروری را به دنبال دارد. مهمترین باکتری های مرتبط با عفونت های مجاری ادراری-تناسلی مردان شامل کلامیدیا تراکوماتیس، نایسریا گونوره و برخی گونه های تناسلی مایکوپلاسما می باشند. درمان دیر هنگام و نامناسب عفونت های باکتریایی مجاری ادراری-تناسلی مردان منجر به کاهش توانایی باروری و در موارد شدید به ناباروری منتهی می شود. از سوی دیگر، دانستن نحوه تداخل عفونت های باکتریایی با فرآیندهای فیزیولوژیک سیستم تولید مثل، نقش مهمی در درمان مردان نابارور در اثر عفونت باکتریایی مجاری ادراری- تناسلی دارد. بنابراین، در این مقاله مروری در مورد یافته های آزمایشگاهی و بالینی در رابطه با اثرات عفونت های باکتریایی مجاری ادراری- تناسلی مردان بر توانایی باروری بحث خواهیم نمود.
    کلید واژگان: ناباروری مردان, عفونت باکتریایی, اسپرم, گونه های واکنشگر اکسیژن}
    Hamed Fanaei, Jalal Mardaneh, Samira Khayat
    An important cause of male infertility is the bacterial infections of the genitourinary tract. These infections affect sperm cell function and whole spermatogenesis and also cause deterioration in spermatogenesis, obstruction of the seminal tract, and impairment of spermatozoa function. The most important bacteria associated with genitourinary tract infections include chlamydia trachomatis, Neisseria gonorrhoeae, and genital mycoplasma species. Inappropriate or delayed therapy of the bacterial infections of the genitourinary tract will lead to reduced fertility and, subsequently in severe cases, infertility. In other words, a good understanding of the interaction between bacterial infections and the reproductive system plays an important role in the treatment of infertile men. In this review article, we will discuss clinical and laboratory findings related to the bacterial infection of the genitourinary tract and its effects on male infertility.
    Keywords: Male infertility, Bacterial infection, Sperm, Reactive oxygen species}
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