فهرست مطالب sara babaei

Objectives:

 Interpersonal trust between couples is the most important component of long-lasting and happy marriage. In this study, we aim to investigating the relationship of mentalizing capacity in Iranian couples with their interpersonal trust, considering the mediating role of conflict resolution styles and the moderating role of internal working model of attachment. 

Methods:

 This is an applied descriptive study using the structural equation modeling method. participants were 349 couples aged 18-45 living in Tehran, Iran, with at least one year of marriage and at least a high school diploma, who were selected using a convenience sampling method. The data collection tools were the interpersonal relationship scale, the reflective functioning questionnaire, the Rahim organizational conflict inventory-part two, and the relationship scales questionnaire. Statistical analysis was done in SPSS software, version 22 and PLS version 3.

Results:

 The values of fit indices showed a good fit of the initial model. After the removal of non-significant paths, the results showed a good fit of the final model (standardized root mean squared residual index=0.017, normalized fit index=0.985, goodness-of-fit index=0.386). 

Conclusion:

 The mentalizing capacity of couples has a direct relationship with their conflict resolution styles. Their conflict resolution styles have a direct relationship with their interpersonal trust. The mentalizing capacity of couples has both direct and indirect relationships (mediated by conflict resolution style) with their interpersonal trust. Only the preoccupied internal working model of attachment has a moderating role in the relationship between the mentalizing capacity and conflict resolution styles of Iranian couples.

Inflammation and its master regulator, Nuclear Factor-kB (NF-kB), have been implicated in the development of endometriosis. Inhibition of NF-kB pathway using small molecules ameliorated disease progression and reduced the lesion size; nevertheless, the underlying mechanism is not fully understood. Therefore, this study, is an attempt to assess whether inhibiting NF-kB signaling by aloe-emodin (AE) or aspirin (Asp), as anti-inflammatory compounds, can suppresses the invasive activity of human endometrial stromal cells at stage IV endometriosis.

The eutopic and healthy endometrial biopsies from a total of 8 infertile women with confirmed endometriosis and 8 women without endometriosis were digested and the single cells were cultured. Gene and protein markers of proliferation, migration, adhesion, and invasion of eutopic endometrial stromal cells (EuESCs) with and without treatment with AE or Asp, as well as control endometrial stromal cells (CESCs) was analyzed using q-PCR and immunofluorescence staining, respectively. Comparison between groups was performed using one-way ANOVA and the Bonferroni post hoc and p≤0.5 was considered statistically significant.

There was an association between NF-kB overexpression and higher proliferation/adhesion capacity in EuESCs. EuESCs (at stage IV endometriosis) displayed no invasive and migratory behaviors. Pre-treatment of EuESCs with AE or Asp significantly attenuated NF-kB expression and reduced proliferative, adhesive, invasive, and migratory activity of endometrial cells (p≤0.5).

Eutopic endometrial stromal cells seem to have a semi-invasive activity which is largely suppressed by AE or Asp. It can be suggested that both Asp and AE (as potent NF-kB inhibitors) can be used as a supplement in conventional endometriosis treatments.