فهرست مطالب sara chetehouna

Cancer is one of the most devastating disorders of the 21st century, creating a major concern among clinicians and researchers. Many different treatment strategies are being tried to fight the war against cancer have been tested. Various inorganic nanoparticles have been investigated to induce cytotoxicity in cancer cells and one of the successfully tried nanoparticles is Selenium Nanoparticles (SeNPs). Green synthesized SeNPs are a promising source of new antioxidant and anti-inflammatory agents, given the multiplicity of its mechanism. SeNPs displayed antiproliferative potential against colon, liver, cervical, breast, melanoma, and prostate cancer cells by several mechanisms, including triggering apoptotic signal transduction pathways or slow down the angiogenic signalling in cancer cells. Metal nano-therapies such as SeNPs are granted research consideration for cancer treatment. The biocompatibility achieved through green synthesis suggests its possible use not only in specific cancer conditions but also in other types of cancer without any risk of toxicity of these molecules.

One of the major roles of nanotechnology in pharmaceutical field is to provides a facility to improve the drug delivery systems and design smart nanocarriers which have the potential to deliver specific biomolecules to the target site for treatment. In this study, we were evaluated a niosomes loaded Sonchus maritimus (SmE-N) on hepatic encephalopathy induced by high fructose diet (HFD) in rats. High performance liquid chromatography (HPLC) analysis of Sonchus maritimus extract (SmE), synthesis of niosomes and its characterization were performed. For in-vivo study, 24 male rats were haphazardly divided into 4 groups (n=6); Control, HFD (35%), HFD + SmE-N (50 mg/kg/day) and HFD + metformin (50 mg/kg/day). Clinical behaviors and Biological markers were assessed for all groups. In vitro results of chromatographic analysis revealed that S. maritimus contains important phenolic acids including gallic acid, vanillic acid, chlorogenic acid and caffiec acid, and divers flavonoids including quercetin, rutin and naringin bioactive compounds. The niosome formulation characterized by encapsulation efficiency of SmE reached up to 61.40%. In-vivo results, HFD showed a significant change in behavior parameters, liver glycogen, transaminases enzymes; brain protein and acetylcholine esterase (AChE) levels. In addition, a significant increase in malondialdehyde (MDA) levels and decrease in reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in HFD group compared to control group. Furthermore, histopathological observation recorded a profound modification in liver and brain tissues of HFD group. In contrast, the treatment by the SmE-N and Metformin assured a partial amelioration in noticed parameters compared to HFD group, while SmE-N seems a better improvement than the metformin treatment when compared to control group. As conclusion, use of SmE-loaded niosomes and bio-conjugated with linoleic acid seems its powerful to treat complications of fructose-induced metabolic disorder through its hepato-neuroprotective abilities.

Coronavirus disease (COVID-19) has killed a large number of people, threatening public health around the world. Many drugs and materials that have an antiviral therapeutic effect are still being tested, including silver nanoparticles.

It has been proven that Synthesis of silver Nanoparticles (Ag NPs) (Ag NPs) possess strong antifungal, antibacterial, anti-angiogenesis, and anti-inflammatory potential. Green synthesized of Ag NPs are a promising source of new antiviral agents considering the multiplicity of its mechanism and the multiple target areas in the virus. The Ag NPs or Ag+ ions, which are released from the Ag NPs, interact directly with some biological molecules of the viruses that contain phosphorous or sulfur, such as some proteins, Deoxyribonucleic Acid (DNA), and Ribonucleic Acid (RNA).

This reaction generates Reactive Oxygen Species (ROS), causing damage to the membranes in the virus. Metal nano-therapies such as Ag NPs are granted research consideration for COVID-19 treatment.

The biocompatibility achieved through green synthesis suggests its possible use not only in these specific coronavirus conditions but also in other types of virus infections without any risk of toxicity of these molecules.