sayyed hesamedin nabavizadeh

A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses.

Because some children have allergies to egg as an important food source, finding the right alternative is essential. To date, the interaction between other birds’ eggs and hen egg has not been investigated in Iran. Because of the common usage of eggs from birds other than hens in Iran, the present study aimed to compare hens’ eggs with the eggs of other birds. In this case-control study, 70 children who referred to our allergy clinic were evaluated. In patients who had a history of egg allergy, SPT and specific IgE Ab analyses were done, and then an oral food challenge (OFC) was performed. Patients with egg allergy underwent skin prick tests with eggs from birds such as turkey, goose, duck, quail, partridge, and pigeon. From 40 patients with egg allergy, 8 patients passed the OFC. The greatest cross-reactions were seen in turkey and quail egg extracts. The least cross-reactions were reported in partridge and pigeon. Among patients who had negative SPT with partridge egg (N=3), one patient passed and two failed the OFC. Three of the patients who had negative pigeon SPT (N=5) passed the OFC with pigeon egg. In conclusion, turkey, goose, duck, and quail eggs cannot be used as an alternative to hen eggs; only partridge or pigeon eggs can be considered as a suitable alternative to hen eggs.

Kawasaki disease is a multi system disorder with varying clinical expressions. This disease is an acute systemic vasculitis of unknown etiology that has recently recognized as a leading cause of acquired heart disease in children of many developed countries. We describe an unusual instance of hair loss in a patient with Kawasaki disease. A 26 months old boy developed prolonged high fever, bilateral conjunctival infection, arthralgia and erythromatosis skin rash. He was admitted to the hospital with the diagnosis of Kawasaki disease. Laboratory results included an erythrocyte sedimentation rate (ESR) above 100 and platelet count > 1000,000. The patient developed acute and unprovoked scalp hair loss. He was treated with intravenous immunoglobulin (IVIG) 2 g/kg and aspirin 100 mg/kg/day with complete improvement of signs and symptoms. This report documents hair loss as an uncommon presentation of Kawasaki disease.