seyede fatemeh hosseini

Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women. Previous research has shown that PCOS is associated with insulin resistance, oxidative stress, and immune system malfunctions. Also, the antioxidant effects of propolis and the positive effects of chitosan nanoparticles on the reproductive system have been demonstrated in some reports.

The current study is designed to investigate the protective effects of chitosan-propolis nanoparticle against estradiol valerate-induced (EV) PCOS model of rats compared to metformin (Met) (as a control treatment).

Intramuscular injection of EV (4 mg/kg, 28 days) was used to induce PCOS in rats, followed by oral administration of 500 mg/kg chitosan-propolis nanoparticle for 42 days. Rats were divided into 4 groups: Control, PCOS, metformin (PCOS and 150 mg/kg metformin), and chitosan-propolis nanoparticles (PCOS and chitosan-propolis nanoparticle administration, 500 mg/kg) groups.

All animals were subjected to serum factors analysis and histopathological study of ovaries. Estradiol valerate-induced induced PCOS while administration of chitosan-propolis nanoparticle recovered it. The body weight (P < 0.01) and ovarian morphology improved. The serum biochemical parameters, including estrogen (P < 0.05), progesterone (P < 0.001), vitamin D (P < 0.01), calcium (P < 0.01), and insulin resistance index (P < 0.05) were reversed after chitosan-propolis nanoparticle intervention. These EV-induced alterations included inhibited superoxide dismutase (SOD) activity (P < 0.05) and increased malondialdehyde (MDA) level (P< 0.001), and it was demonstrated that chitosan-propolis nanoparticle/Met administered for 42 consecutive days and gavages with EV reversed the oxidative stress factors. Additionally, in EV-treated animals, there was a significant upregulation of certain relativemRNAexpressions, such as monocyte chemoattractant protein (MCP) (P< 0.01), interleukin 18 (IL-18) (P< 0.05), and C-reactive protein (CRP) (P < 0.01) genes. These data clearly show that chitosan-propolis nanoparticle/Met may have a protective effect on this inflammatory disorder.

Taken together, the final results of this study are consistent with the assumption that chitosan-propolis nanoparticle /Met had ameliorative and protective effects against the harmful effects of EV. Although it is hypothesized that ameliorative effects might have been involved, the fundamental pathways remain to be illuminated.

The COVID-19 epidemic is a serious challenge for clinical education that has made nursing students and their tutors face problems in the learning and teaching process. The mean score of quality of clinical education in nursing students was obtained at 36.99±9.14 during the COVID-19 pandemic. The highest mean quality score of clinical education belonged to the “I willingly and voluntarily come to the bedside to perform educational procedures” (4.38±1.4), while the lowest mean score was related to the item “In general, due to the restrictions created by the COVID-19 conditions, I feel that the quality of clinical education has decreased” (2.15±1.18). It is highly recommended to carry out educational interventions to improve the educational goals in the clinical environment, boost the clinical performance of instructors, enhance communication between medical staff and nursing students, revise the evaluation process of nursing students, and increase the quality of welfare facilities in medical centers.

Cardio-pulmonary resuscitation (CPR) training with modern educational tools is very important to save the lives of people who need CPR in the adolescent age group. This study was conducted with the aim of comparing the effect of CPR training by face-to-face and electronic methods on the skills of secondary school students.

The statistical population included all nursing students of Tabas School of Nursing in 2018.  Sixty-two samples were selected by simple random sampling method and were assigned to  two groups of electronic education (31 people) and face-to-face education (31 people). The data collection tool was a questionnaire which included a demographic section and a checklist of CPR and Automated external defibrillator (AED) skills related to CPR. Then, both groups completed the questionnaires before, one week after, and two months after the intervention. Data analysis was done using SPSS software and independent t-test was used after ensuring normality. A significance level of P> 0.05 was considered.

The average score of CPR skill before the intervention and one week after the intervention in both electronic and face-to-face training groups had no statistically significant difference (P=0.412). In both electronic and face-to-face training methods, the average CPR skill score increased significantly before and two months after the intervention, and the average score of the face-to-face training group was higher (P=0.05).

Considering the higher mean intervention scores in both electronic and face-to-face education methods, it seems that the educational intervention after two months has improved the level of students' knowledge and skills in the field of CPR.

Azo dyes, as a major group of the synthetic colorants, are added to food products not only to make them aesthetic but also to preserve their appearance. However, the use of azo dyes in food has been banned worldwide due to side effects on human health. The search was conducted using PubMed, Scopus, Web of Science, Europe PMC beta, Science Direct, and Springer database considering all articles published up to 9 July 2021. The inclusion criteria were double-blind, randomized, cohort studies, placebo-controlled trials, case reports, non-controlled trials, and case series. Several studies suggest that azo dyes induce oxidative stress, which subsequently increases the concentration of malondialdehyde and reduces superoxide dismutase (SOD) activity and glutathione (GSH) concentration in brain tissue. Also, results showed the adverse effects of azo dyes on the brain parts such as the prefrontal cortex, cerebellum, and cerebrum which, are accompanied by changes in brain function. It can be concluded that azo dyes with an increase in oxidative stress affect the most important parts of the brain and cause brain dysfunction. This study aimed to evaluate the effects of the food additive azo dyes on brain tissues.

Anemia patients are more susceptible to environmental contaminations such as heavy metals. The present study aimed at risk assessment of heavy metals in edible mushrooms and Anemia.The databases searched in those articles were Google Scholar, SID, Scopus, PubMed, Science Direct, and ISI. Related human health risks were calculated using the target hazard quotient (THQ). THQ ratio of Cd, Cu, Fe, Pb, Cr, Ni, and Mn were 3×10−3, 2.31, 8.43×10 −1, 2.35, 2.92×10−1, 6.6×10− 2 and 1.96×10− 1 m m-1 respectively. The highest non-carcinogenic diseases risk for adults were found in Pb (2.35 m m-1) while the lowest value was observed in Cd (3×10− 3 m m-1). The risk of carcinogenicity of lead was at the level of acceptable (10−4 to 10−6 m m-1). There is no concern about the non-carcinogenic risk of consuming heavy metals in edible mushrooms, in Iran except Cu and Pb. In some countries, adults and children can be exposed to non-cancerous foods by eating mushrooms. And can aggravate anemia in the consumer.

Today, wireless communication systems are destructive with increased lipid peroxidation and oxidation state and have adverse biological effects on human health.

In this study, we examined the effects of exposure to WiFi wireless frequency (2.4 GHz) on histopathological changes in the cardiovascular system of rats.

The experimental groups included 32 adult male rats divided into control (not exposed to heat and WiFi), WiFi (exposed to 2.45 GHz for 52 consecutive days (2 h/day)), heat (water bath of 43°C for 52 consecutive days (10 min/day)), and heat+WiFi groups (exposed to 2.45 GHz then water bath of 43°C). On the 52nd day, the heart was removed, and its total volume and weight were determined using stereological techniques. The number of cardiomyocytes nuclei and the volume of the myocardium were determined. Blood samples were collected to measure reduced glutathione (GSH) content, Total Antioxidant Capacity (TAC), and malondialdehyde level (MDA). Data were analyzed by ANOVA, Kruskal-Wallis, and Mann-Whitney U tests.

The heart weight and volume density of the myocardium increased in the WiFi-irradiated group compared to the control group (P < 0.05). Also, exposure to WiFi increased MDA levels and decreased TAC and GSH compared to the control group (P < 0.05).

This study indicated that RFW might cause structural changes and oxidative stress in the heart. Also, exposure to radiofrequency decreased total antioxidant activity in heart tissue with histological changes, including myocardium hypertrophy and decreased number of myocytes.

Rhus coriaria L. (Anacardiaceae), generally known as sumac, is a commonly used powder spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, R. coriaria (RC) has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, and reduction of blood sugar, cholesterol and uric acid levels. R. coriaria is rich in various classes of phytochemicals including polyphenol compounds, flavonoids, anthocyanins, tannins, organic acids, and many others. By virtue of its bioactive, R. coriaria possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including neurodegenerative disease, diabetes, and cancer. The purpose of this study is a brief review of the effects of R. coriaria on diabetes, cancer, hyperlipidemia, as well as the study of anti-inflammatory and antioxidant properties of this plant. Due to its mineral elements, neurotransmitters, organic acids and high antioxidant ability, Sumac plant can cause significant changes in various organs of the body when consumed.  To sum up, the findings summarized here can be used as a useful dietary supplement and an attractive target for drug discovery.

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme-A Reductase inhibitor widely used in lowering cholesterol levels.This study was aimed at assessing the effect of simvastatin on the activity of nitric oxide synthase in the vascular endothelial cell line HUVEC. MTT method was used to evaluate the effect of simvastatin on HUVEC vascular endothelial cell line. The effect of simvastatin on iNOS gene expression in HUVEC vascular endothelial cell line was investigated using real-time PCR technique. The effect of Simvastatin on the activity of endothelial nitric oxide synthase was investigated using grease colorimetry. With increasing Simvastatin concentration, the survival of HUVEC vascular endothelial cells decreased compared to the control group (P≤0.05). In addition, the expression of INOS enzyme gene in the group receiving 55 µl/ml of simvastatin was significantly different and increased compared to the control group (P≤0.05). Simvastatin at concentrations higher than 125 µl/ml simvastatin was not significantly different from the control group. However, at lower concentrations (62, 31, and 16 µl/ml), a significant difference was observed and increased compared to the control group (P≤0.05). Considering the decrease in the level of endothelial nitric oxide synthase and its effects on human diseases, especially cardiovascular diseases, the use of simvastatin can be helpful in patients exposed to disease due to endothelial nitric oxide dysfunction..

Brain tumors are among the most lethal and devastating cancers. Medulloblastoma tumor is a common solid brain malignancy, arising in the posterior fossa. Stereological methods are used in combination with magnetic resonance imaging (MRI) to obtain unbiased estimation of the total volume of the structure of interest.

In the current study, we evaluated cerebellar tumor volume pre- and post-operative in patients suffering from meduloblastoma tumor using MRI and Cavalieri method.

The study was performed on 16 subjects consisting of two groups of eight people including patient and control groups. Slide direction were in both sagittal and axial planes. Pre- and post-operative volume of medulloblastoma tumor were determined on MR scanning images using the point-counting approach of Cavalieri method.

The post-operative tumor volume in both sagittal (P = 0.028) and axial (P = 0.046) MR images was statistically reduced by 90% compared to the pre-operative volume. Moreover, the pre-operative volume of the cerebellum in patients increased by 38% in patients as compared to the normal subjects (P = 0.028).

It could be concluded that MRI-estimated tumor-volume might be useful in evaluating the efficiency of surgical treatment and prognostication of tumor regression rate.

This study explored the simple and multiple relationships between the Big Five personality traits and the job attitudes in a productive company’s staff. To do so، 280 indivituals from the staff were selected by stratified random sampling method. To assess the study’s variables، NEO-Five Factor Inventory، Job Descriptive Index، Organizational Commitment Questionnair، and Job Involvement Questionnair were used. In order to analyze obtained data، Pearson correlation and multiple regression method were employed. Results indicated that the Five Big personality traits were strong predictors of job attitudes. As a matter of fact، the Big Five personality traits explained 12% of the total job satisfaction، 9% of the variance in organizational affective commitment، 7% of the variance of organizational continuance commitment، 12% of the variance of organizational normative commitment، and 14% of the variance of job involvement. Theoretical and practical implications of the results are discussed.