فهرست مطالب seyyed hosein mousavi

Normal tissue injury is one of the biggest concerns for cancer therapy as also exposure to radiation accidents. Damage to radiosensitive organs such as bone marrow and gastrointestinal system, lung, liver, and kidney is the most important reason for mortality or reduced quality of life caused by long-term side effects of exposure to ionizing radiation. The use of antioxidant compounds and radioprotectors is one of the best options for reducing radiation effects. This study is a narrative review that overviews the capability of antioxidants and natural plant compounds for ameliorating radiation-induced damage. Using natural antioxidants and radioprotectors is one of the best choices for the amelioration of radiation side effects. Although to date, some chemical agents have been studied for this aim, natural antioxidants with low toxicity are more interested in mitigation of radiation accidents after radiological and nuclear accidents. In the current review, natural antioxidants and herbal agents for the amelioration of damages caused by exposure to radiation will be discussed. The need for further research in this area is a significant gap that can be attributed to further applied studies in the future. It seems that natural radiomitigators can play an effective role in treating side effects and reducing mortality after radiation disasters. The need for further research in this area is a significant gap that can be attributed to further applied studies.

We aimed to investigate the extent of pulmonary involvement and adverse outcomes in patients receiving angiotensin-converting enzyme inhibitor (ACEI)/ angiotensin II receptor blocker (ARB) versus who did not, in hospitalized coronavirus infectious disease 2019 (COVID-19) patients. 

All COVID-19 patients with a positive polymerase chain reaction (PCR) test, who were admitted to our tertiary referral hospitals in Tehran, Iran between January 2021 and May 2021, and had an on-admission chest computed tomography (CT) scan, were included. The patients were divided into two groups (receiving ACEI/ARB and who did not) for further analysis. The outcomes of interest in our study were the extent of pulmonary involvement, intensive care unit (ICU) admission, and death. 

A total of 893 participants (mean age of 58.6±15.4 years; female, 522 (58.4%)) were enrolled. Among them, 368 (41.2%) participants had hypertension, and use of ACEI/ARB was reported in 183 (20.5%) participants. Of all, 409 (45.8%) participants required ICU admission, and 259 (29%) participants succumbed to death. We found that participants who received ACEI/ARB were less likely to progress critical disease and experienced significantly lower ICU admission (P=0.022) and death (P<0.001). On multivariable analysis adjusting for age, sex, and comorbidities, this relationship remained statistically significant for death [OR: 0.23 (0.14-0.38); P<0.001] and ICU admission [OR: 0.49 (0.32-0.73); P=0.001]. 

Our findings showed that COVID-19 patients who receiving ACEI/ARB prior to hospitalization vs. those who did not, had more favorable outcomes.

The purpose of the present research was to compare the effect and follow up of eight-week corrective exercises with and without the myofascial release forward head and forward shoulder deformity in young adults.

A total of 45 male students suffering from abnormal forward head more than 46° and forward shoulder more than 52° deformity with the Mean±SD age of 22.12±2.88 years, height of 175.44±6.80 cm, and weight of 71.21±7.31 kg were selected and randomly distributed in three groups: corrective exercises, combinational exercises (corrective and myofascial release), and control. These groups performed the exercises for eight weeks under the direct observation of the researcher. Prior to starting the exercises, after the end of eighth week, and four weeks after the end of the exercises, the angles of the forward head and forward shoulder of the participants were measured using a photography method. Then, the collected data was analyzed using the variance analysis tests with repeated measurements and ANCOVA.

The results showed that the degree of forward head and forward shoulder after eight weeks of exercises in both training groups in post-test and follow-up test was significantly lower than those of the pretest. The ANCOVA test results also demonstrated that the forward shoulder degree in corrective exercises group with myofascial release in post-test and follow-up test was significantly lower than that of the corrective exercises (P≤0.05). However, the forward head degree did not show a significant difference between the intervention groups in post-test and follow-up tests (P≥0.05).

According to the results, it can be stated that the corrective exercises program with myofascial release is more effective than the corrective exercises in correcting the forward shoulder deformity.

 Granulomatosis with polyangiitis (GPA) is a kind of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), which involves small-to-medium-sized vessels. Besides, GPA usually involves the upper and lower respiratory tract, and also causes necrotizing glomerulonephritis. The involvement of the heart and gastrointestinal (GI) tract in GPA is unusual, and these are atypical places of this vasculitis.

 A 14-year-old girl with a newly diagnosed GPA after afflicting with COVID-19 infection presented with ST-elevation Myocardial Infarction (MI), GI perforation, and intracranial hemorrhage.

 Although GPA is rare in the pediatric population, it might occur in this age group and could involve multiple organ systems.