sh.abdollahzadeh

Oral health problems of chronic renal failure patients can compromise systemic health. The purpose of this study was to investigate the dental and periodontal status of patients on regular hemodialysis (HD) maintenance therapy and the effect of duration of HD on oral health. Methods & Materials: In this historical cohort study 65 HD patients and 65 healthy people were collected as case and control groups. Decayed (D), Missed (M) and Filled (F) teeth, DMFT Index, Plaque Index (PI), Gingival Index (GI), and Probing depth (PD) were examined and compared between case and control groups. Also, HD patients were divided into two subgroups based on duration of hemodialysis: 1: three and less than three years and 2: more than three years). In this study all variables were examined and compared between these subgroups. T-test and chi-square and SPSS software were used for statistical analysis.

Except M and DMFT index, significant differences were found in other indices between case and control groups (P<0.05). D, M, F, DMFT values showed no significant differences between the two HD subgroups, whereas, PD, GI and PD values had significant increase in two groups based on the duration of hemodialysis.

The dental and periodontal health is poor in HD patients and periodontal status becomes worse specially during the time of dialysis.

The clinical symptoms of diabetes mellitus in oral cavity are xerostomia, pathological changes in periodontal tis sues and caries. It has been suggested that the determination of salvia`s components in diabetic patients may be useful in de scribing and further understanding the oral findings in this condition. The aim of this study was to detect differences be tween the salivary albumin in diabetic patients and healthy people. A case-control study was carried out using data from Hamadan researches diabetes center in 2008. We selected 40 patients with type 1 diabetes mellitus aged 9-61 years, 40 patients with type2 aged 39-82 years and 40 healthy controls aged 20-67 years. Dental and oral status was assessed for all subjects. Completely unstimulated saliva samples were col lected from diabetic patients and control subjects. Nephelometric method was used to determine salivary albumin con centra tion. Statistical analysis was done by SPSS. No significant difference in salivary albumin concentration was found between the control group and type1 dia betic patients but salivary albumin was significantly higher in type2 diabetic patients in compare with control groups (P= 0.017), also no significant difference was found between type1 and type2 diabetic patients. In diabetic patients, complain of dry mouth and burning feeling in mouth was significantly higher, as well as, dental examinations showed higher DMFT mean values than the controls. Adults with type2 diabetes mellitus have higher concentration of salivary albumin that would play a helpful diagnos tic role in oral findings of diabetic patients.

Hepatitis B infection is a major public health problem worldwide. Dental students who are frequently in contact with body fluids like blood and saliva are still at high risk for HBV exposure. The aim of this study was to evaluate the effectiveness of HBV vaccine and personal factors associated with serologic evidence of the immune response. A descriptive-cross sectional study was carried out using data from Hamadan dental school students that received just three doses of HBV vaccine. The serum sample of 86 dental clinical students were examined in order to determine hepatitis B surface antigen and the level of anti-HBs using IEMA method. Logistic regression models were used to assess the relationship of vaccine response to the variables Sex, age weight, smoking status and the time lasting from the third dose of vaccine injection. Ninety-three percent had positive anti-HBs response and 7% were non-responders. No one showed HBsAg. Vaccine response was most strongly associated with age, smoking status, sex and weight. The time lasting from the third dose was unrelated to vaccine response. Clinical dental students had desirable immune response to the HBV vaccine nevertheless recommended num ber of doses, standard protocol and early vaccination are critical to adequate protection against hepatitis infection among all health care workers, in particular dental students and dentists who are often exposed to blood and other body fluids.

Statement of problem:

 Recurrent aphthous ulcers (RAU) are one of the most common ulcers in the oral cavity. Several studies have shown conflicting variations for inflammatory cytokines and other biologic markers in recurrent aphthous ulcers.

The aim of the present study was to determine the level of IL-8 and IL-6 in the serum of patients with recurrent aphthous ulcers.

In this case- control study, the serum levels of IL-8 and IL-6 were measured in patients with recurrent aphthous ulcers (n=40) and in healthy control subjects (n=40). The cytokines levels were measured in the serum by ELISA. The data were analyzed with SPSS software using T- test.

The mean value of the IL-8 and IL-6 in the patient group was 52.24 pg/ml and 9.39 pg/ml which was 10 and 4 times higher than that of the control group, respectively. The differences were statistically significant (p <0.01).

The results of the present study showed that the serum levels of IL-8 and IL-6 were elevated in the patient group, IL-8 level being more considerable.