siamak afshin

Headache has a high prevalence. Iranian Traditional medicine is a valuable treasure of the knowledge and experience of our country's scientists and it contains valuable solutions in the field of lifestyle modification for the treatment of diseases called science of Tadabir. The aim of the study was to identify gastric headache managements, what one of the of headache types mentioned in the books of
hokama. This study has been conducted as library method. Recommended strategies of the Iranian traditional Medicine and the scientific evidences of Conventional medicine in the field of headache management were collected and topics were classified in the six necessary principles (setteye zarurieh) are described and presented. Some of the Gastric corporate headache measures, in Iranian Traditional medicine approved by conventional medicine practice. Iranian Traditional medicine has valuable doctrines and strategies for healthy lifestyle and nutrition, in the case of all diseases, especially gastric corporate headache. Use of these measures can be useful in preventing, treating or reducing the number of headache attacks, reducing the duration of headaches, reducing the severity of headaches, and improving the quality of life of patients with headache and paying attention to these strategies will reduce direct and indirect costs of primary headaches.

Parkinson's disease (PD) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. Due to the protective, anti-inflammatory, and antioxidant effect of Hypericum perforatum (HP), this study was undertaken to assess dose-dependent effect of HP hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydopamine in the rat.
In this experimental research, male Wistar rats (n=35) were equally divided into sham, 6-hydroxydopamine (OHDA)-lesioned, and HP extract-treated lesion groups. Model of PD was induced by microinjecting 12.5 microgram of 6-OHDA dissolved in saline-ascorbate solution into the left striatum. Treated lesion groups received HP extract at doses of 50, 100, and 200 mg/kg/day p.o. started one week before the surgery for 1 week post-surgery. After 1 week, ipsilateral and contralateral rotations induced by apomorphine were counted and net scores were obtained.
In the 6-OHDA-lesioned group, the dopaminergic agonist apomorphine induced contralateral rotational behavior (P
Oral administration of HP extract at doses of 100 and 200 mg/kg could reduce motor imbalance and attenuate forced biased rotational behavior in 6-OHDA-induced model of PD.

Deleterious effect of neurotoxins on the brains of animals is an attractive research topic. In this research, the effect of microinjection of colchicine into the hippocampal CA1 was shown by examining the novelty seeking behavior. Also, the effect of pre-injection of galantamine, an effective agent in the treatment and prevention of Alzheimer's disease, for reversal of colchicine’s side effect in that region was also examined. Ninety six male Wistar rats were bilaterally cannulated at the hippocampal area (AP: -3.8; L: 1.8 ± 2.2; V: 3). They experienced a three-phase novelty seeking task in the unbiased conditioning apparatus after one week: in day 1, the animals moved freely (10 min) in the box to familiarize with the device; over the next consecutive three days, they were confined in one part of the apparatus (40 min, twice daily); finally (Day 5), the animals were injected colchicine (25 µg/rat hippocampus, n = 8) prior to testing (lasted 10 min/similarly to the familiarization situation). The galantamine groups received the drug (1-25 µg/rat hippocampus; n = 8) solely or prior to the colchicine. The negative control only received saline (1 µL/rat hippocampus). As the data show, the injection of colchicine significantly caused an increase in the locomotor activity of the treated animals. The lonely galantamine groups though showed no significant difference versus the control group, but in pre-galantamine groups, the enhanced activity was reversed. The side effects of colchicine on the brain of the laboratory animals have been shown; the most important of them is the destruction of granular neurons of the hippocampal formation. The effect of this material on the cortical pyramidal neurons is still unknown. The present study shows the increased locomotor activity of the animals due to the injection of colchicine into the hippocampus. This effect was reversed by pre-injection of galantamine and it is probable that the effect was modulated by the neuronal mediators.

Memory naturally degrades with the passing of time. Dementia or deficit of memory caused by Alzheimer’s disease, aging and other risk factors, greatly affects one’s day-to-day life. Lavandula officinalis is an effective medicinal plant in treating inflammation, epilepsy, depression and anxiety. Also, recently have been submitted reports about the effects of lavender on memory improvement. However, the effect of aerial part hydro-alcoholic extract of Lavandula officinalis has not been studied on passive avoidance and spatial memory in rats with healthy memory. In this study, 40 male NMRI rats weighing 200-250 g were used. Animals were divided into four groups (n=10 each). Control group (group 1) received normal saline, daily, for 9-11 continuous days; groups 2, 3 and 4 received Lavandula officinalis aerial part hydroalcoholic extract at doses of 100,200 and 400 mg/kg intraperitoneally (i.p), daily, for 9-11 continuous days 60 min before the behavioral testing. Passive avoidance and spatial memory was tested by shuttle box and Y maze, respectively. Chronic administration of the extract at a dose of 400 mg/kg significantly enhanced spatial memory in Y maze and also passive avoidance memory in shuttle box. Repeated consumption of Lavandula officinalis (400 mg/kg) in rats with healthy memory may cause memory potentiation.

Parkinson's disease is a rather common movement disorder in aged individuals due to degeneration of dopaminergic neurons within the substantia nigra pars compacta. Due to antioxidant, anti-inflammatory and protective effects of the flavanone hesperetin, the present study assessed dose-dependent effect of hesperetin on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat. In this experimental study, male rats (n=35) were divided into sham, lesion, and hesperetin-treated lesion groups. Model of Parkinson's disease was induced by injecting 12.5 microgram of 6-hydroxydopamine-ascorbate dissolved in saline-ascorbate solution into the left striatum. Treated lesion groups received hesperetin at doses of 5, 15, and 50 mg/kg/day p.o. one hour after surgery for 1 week. After 1 week, leftward and rightward rotational behavior induced by apomorphine was assessed. In the lesion group, apomorphine caused contralateral rotational behavior (P<0.001). Administration of hesperetin only at a dose of 50 mg/kg significantly reduced the number of contralateral rotations (P<0.05) and it had not such an effect at other doses. Oral hesperetin treatment at a dose of 50 mg/kg reduces motor asymmetry (attenuation of rotational behavior) in an experimental model of Parkinson's disease.