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Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages.
Adult male Wistar rats were divided into control and test groups (n=8). The test group was assigned into five subgroups; 4 groups, along with paclitaxel administration (7.5 mg/kg BW, weekly), received various doses of royal jelly (50, 100, and 150 mg/kg BW) for 28 consecutive days. The last group received only royal jelly at 100 mg/kg. In addition to oxidative and nitrosative stress biomarkers, the creatine kinase (CK-BM) level was also determined. To show the cardioprotective effect of royal jelly on paclitaxel-induced damages, histopathological examinations were conducted.
Royal jelly lowered the paclitaxel-elevated malondialdehyde and nitric oxide levels in the heart. Royal jelly could also remarkably reduce the paclitaxel-induced cardiac biomarker of creatine kinase (CK-BM) level and pathological injuries such as diffused edema, hemorrhage, congestion, hyaline exudates, and necrosis. Moreover, royal jelly administration in a dose-dependent manner resulted in a significant (POur data suggest that the paclitaxel-induced histopathological and biochemical alterations could be protected by the royal jelly administration. The cardioprotective effect of royal jelly may be related to the suppression of oxidative and nitrosative stress.

Speed of disappearing animal species convinces most of the zoologists that we are having the sixth big extinction, an extinction which is because of the human activities. Asiatic lion (Panthera Leo Persicus), Persian leopard (Panthera pardus saxicolor), Chita, Vulpes Cana, Alaotra grebe, Palas cat, Polar bear, Koala are endangered of extinction species. So as endangered species are disappearing from natural habitats and are limited to the ones which are found in zoos, researchers are looking for ways to save these species. Genetic engineering introduces new ways of cloning using the technique which created Dolly the sheep; to generate endangered animals in the eggs and wombs of common creatures such as cows. Researchers have opened the door to a future where even extinct species such as mammoths could walk on the earth again. In this article we have tried to show the importance of the subject and present some ways of saving these endangered species in order to draw scientist’s attention to it.