sorush jafari

Glioblastoma multiforme (GBM) is an aggressive cancer with a poor prognosis. Inflammation and angiogenesis are important processes in GBM that are interrelated. In this study, bioinformatic investigations were performed to detect common and key genes in the inflammatory and angiogenesis pathways of GBM. Additionally, relevant long non-coding RNAs (lncRNAs) were recognized as important gene regulators. Consequently, real-time PCR and correlation analyses were used to investigate changes in gene and lncRNA expression levels and explain their relationship. RELA emerged as a common key gene in these biological processes. LINC01366 and LINC01433 were identified as putative RELA regulators in different metabolic pathways using computational assays. According to our findings, the expression levels of RELA, LINC01366 and LINC01433 were found to be significantly upregulated in GBM samples. Correlational studies revealed a significant positive relationship of gene expressions between LINC01366 and LINC01433, indicating that they may have a coordinated effect on GBM biology. Nevertheless, there was no significant correlation between these lncRNAs and RELA. The current study highlights the high expression of LINC01366 and LINC01433 in GBM and emphasizes the importance of studying lncRNAs as putative regulators in the pathophysiology of GBM. Further research is needed to clarify their specific functions, in particular the associated inflammatory and angiogenesis pathways.

The Balharud border river is one of the border rivers between Iran and the Republic of Azerbaijan. Changes in the course of this river over the past years have caused problems in the border strip of the Garmi Border Regiment. The purpose of this study is to investigate the diversion of the Balhorud border river and its impact on the security of border residents in the Garmi Border Regiment. The present research is an applied research that has been done by descriptive-survey method The statistical population of this study includes three groups; 45 employees of Ardabil Border Command, 45 employees of the security department of Garmi and Ardabil governorates and experts in the field of Moghan water affairs and Ardabil regional water company 45 and local experts (villagers and council members) living in border villages of the study area 45 There were 40 people selected for each sample size using Morgan table using simple random sampling method. The data collection tool is a researcher-made questionnaire whose validity was formally confirmed by experts and related experts and its reliability was obtained through Cronbach's alpha test with a rate of 0.70 which indicates good reliability. Data analysis was performed using SPSS and GIS software with simple regression tests. The results of the research indicate that the diversion of the Balharud River has a significant effect on the security of the Garmi Border Regiment and also the diversion of the Balharud Border River has a significant direct effect on illegal traffic, infrastructure destruction and border economy in the Garmi Border Regiment. Redirecting the border river of Balharud has caused illegal border traffic of border residents of the Islamic Republic of Iran and has caused the destruction of border infrastructure. Agricultural and productive, economic activities face serious problems.