tahereh mohammadian

Vitamin D receptor (VDR) gene polymorphism has a role in susceptibility to risk of cancers. The aim of this study was to investigate the association of VDR gene polymorphisms with acute myeloid leukemia (AML).

In this case-control study, qualified patients diagnosed with AML and healthy adult subjects were selected. Four single nucleotide gene polymorphisms of VDR gene (BsmI, TaqI, FokI, and ApaI) were determined using polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) and the odds of having AML was determined by un-adjusted and adjusted logistic regression analysis.

One hundred and thirty-three AML patients and 300 healthy people were studied. There was significant association between the polymorphisms of FokI, and ApaI with increased risk of AML (P= .021, and P

This study showed for the first time that there is a significant association between VDR gene polymorphisms and odds of getting AML, similarly to many other solid tumors. Further studies on different ethnic population considering environmental factors that interact with genotypes are highly recommended.

The aim of this study was to compare the effects of using different levels of royal jelly in semen extender on viatal characteristics of goat sperm after freezing. Semen was collected from four adult bucks twice a week and samples pooled together. Sperm samples (six repeats) containing royal jelly in four levels (0.5, 1, 1.5 and 2%) had been frozen. After semen samples freezing – were thawed and examined in terms of mobility, survival and integrity of the membrane. Average total motility and survival at 1% royal jelly were higher than other treatment and control groups (P<0.05). A significant difference in terms of linearity motility of sperm and plasma membrane integrity was not observed between the treated groups and control group. A significant reduction was observed in the rate of other parameters velocity in Diluent contain royal jelly with the control group (P<0.05). Therefore, the use of royal jelly in goat semen diluent can improve some sperm parameters after freezing process.

Henoch–Schönlein purpura (HSP) is an autoinflammatory disease and systemic small vessel vasculitis that more frequently occurs in children. It is characterized by skin lesion such as Petechia and purpura, gasterointestinal involvement including abdominal pain and gastrointestinal bleeding and arthiritis. Studies have shown that HSP could be due to different infections and genetic factors. Based on the fact that cytokines have important role in this inflammatory disease, CCL2- a chemokine encoding gene- is studied in HSP patients from northwestern Iran. To achieve this goal molecular analysis of polymorphism located in promoter region of this gene is performed. This study was conducted on 40 HSP patients who were referred by immunology and allergy specialists to Genetic Center of Tabriz and after blood sampling and DNA extraction, molecular analysis with PCR-RFLP method was performed to genotype polymorphic region of promoter region of this gene. The results were compared to that of 50 ethnic-sex matched control healthy people. Statistical analysis shows significant association of this polymorphism with development of Henoch–Schönlein purpura disease in this cohort. The frequency of TT and TC genotypes and T allele of CCL2 -C2518T gene polymorphism were significantly higher in HSP patients. CCL2 C-2518T gene polymorphisms were associated with susceptibility to HSP in Northwestern Iran.