tara asgharpour

Malnutrition presents a significant global health challenge, necessitating the creation of innovative treatment strategies.

This study explored the therapeutic impact of pancreatic enzymes on improving growth indicators in children suffering from moderate to severe malnutrition.

In this clinical trial, patients aged 2 to 14 years with growth disorders (Z-score weight below -2) attending a Gastroenterology Clinic were randomly assigned to two groups: Pancreatic enzyme replacement therapy (PERT) and control. The trial involved a pilot study with 30 subjects in each group. The PERT group underwent a 2-month treatment regimen of 1000 U/kg pancreatic enzymes taken with the main three meals, complemented by a nutritional plan. In contrast, the Control group received mineral supplements and followed a regular diet. Demographic data and anthropometric indices, including height, weight, body mass index (BMI), and Z scores, were recorded before and after the intervention.

In this study, a statistically significant difference was observed in the mean values of weight, height, BMI, and appetite among children with growth disorders in the PERT group before and after the intervention. However, no statistically significant difference was found between the mean values in the PERT group and the control group.

The results of this study suggest that the therapeutic effect of pancreatic enzymes on improving growth parameters in malnourished children was not statistically significant. Future randomized trials on a larger scale with longer treatment durations are warranted.