فهرست مطالب thangavel siva kumar

The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the methanol extract of Eupatorium ayapana (MEEA) (Family- Asteraceae) leaves in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) at 72 h interval. The MEEA at 100, 200 and 300 mg/kg and silymarin 25 mg/kg were administered to the CCl4 treated rats. The effect of MEEA and silymarin on serum transaminase (SGOT, SGPT), serum alkaline phosphates (SALP), bilirubin, uric acid and total protein were measured in the CCl4 induced hepatotoxicity in rats. Further, the effects of the extract on lipid peroxidation (LPO), enzymatic antioxidant such as superoxide dismutase (SOD) catalase (CAT), and nonenzymatic antioxidant like glutathione (GSH) were estimated. MEEA and silymarin produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, uric acid, and lipid peroxidation and significantly (P < 0.05) increased the levels of SOD, CAT, GSH and protein in a dose dependent manner. From these results, it was suggested that MEEA possesses potent hepatoprotective and antioxidant properties.

The methanol extract of Bauhinia racemosa Lam. (Caesalpiniaceae) stem bark was investigated for the antioxidant and hepatoprotective effects in Wistar albino rats. Different groups of animals were administered with paracetamol (500 mg/kg, (p.o.) once in a day for 7 days) and carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b.wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The methanol extract of Bauhinia racemosa (MEBR) at the doses of 50, 100 and 200 mg/kg and silymarin 25 mg/kg were administered to the paracetamol and CCl4 treated rats. The effect of MEBR and silymarin on serum transaminase (SGOT, SGPT), alkaline phosphates (ALP), bilirubin and total protein were measured in the rats induced hepatotoxicity by paracetamol and CCl4. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were estimated. The MEBR and silymarin produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin and lipid peroxidation and significantly (P < 0.05) increased the levels of GSH, SOD, CAT and protein in a dose dependant manner. MEBR also showed antioxidant effects on FeCl2-ascorbate-induced lipid peroxidation in rat liver homogenate and on superoxide scavenging activity. From these results, it was suggested that MEBR could protect the liver cells from paracetamol and CCl4-induced liver damages perhaps, by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from paracetamol or CCl4.

The methanol extract of Caesalpinia bonducella leaves were investigated for anti-inflammatory, analgesic and antipyretic activity at the doses of 50, 100 and 200 mg/kg, body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, while hot plate and acetic acid induced writhing methods were used to assess analgesic activity. Yeast-induced hyperpyrexia was used to evaluate the antipyretic activity. In acute phase inflammation, a maximum inhibition 50.6% (p < 0.05), 51.1% (p < 0.05) and 52.3% (p < 0.05) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of Caesalpinia bonducella (MECB) in carrageenan, dextran and histamine induced pedal edema respectively. In the chronic model (cotton pellet induced granuloma) the MECB (200 mg/kg) and standard drug (Indomethacin 10 mg/kg) showed decreased formation of granuloma tissue by 51.8% (p < 0.05) and 56.6% (p < 0.05) respectively. The extract also produced significant (p < 0.01) analgesic activity in both paradigms. In addition, MECB potentiated the morphine and aspirin induced analgesia. A significant (p < 0.01) reduction in hyperpyrexia in rat was also produced by the extract. This study exhibits that the methanol extracts of leaves of C. bonducella possess anti-inflammatory, analgesic and antipyretic activities.