فهرست مطالب zahra esmaeilzadeh

Hair loss is an emotional and stressful condition with an unpredictable profound impact on the social interactions of patients.

This study aimed to evaluate the effect of grape sap on apoptosis in hair follicles.

This experimental study was performed on 126 male Wistar rats within a weight range of 30 ± 250 g. The rats were assigned into seven groups, namely bleomycin group, normal saline group, grape sap group (1 mg/kg), grape sap group (10 mg/kg), grape sap group (100 mg/kg), minoxidil group, and minoxidil plus grape sap group (100 mg/kg). The rats received bleomycin (1.7 mL/kg, four times with the interval of 5 days) and then were treated with grape sap for 21 days. The skin samples were taken from rats on days 7, 14, and 21 (i.e., the last day of the treatment).

The results showed a significant increase in the groups treated with grape sap, compared to the bleomycin-treated group in terms of the number of follicles, sebaceous glands, and blood vessels at the base of every follicle, hair growth length, total antioxidant capacity, and BCL2 gene expression. The use of grape sap showed beneficial effects on the reduction of hair fall.

According to the results, it seems that grape sap can be employed as a non-chemical drug due to its rich compounds, especially antioxidants, and decreases apoptosis in hair follicle cells through increasing the expression ratio of BCL2/BAX, thereby stimulating hair growth.

Background :

The purpose of this study was to investigate the role of traumatic childhood experiences in predicting emotion regulation and object relations in patients with irritable bowel syndrome.

Materials and Methods :

The research method was descriptive-correlational that was performed on 135 patients with irritable bowel syndrome, including 58 men and 77 women, who were selected by convenience sampling method from those referred to the gastroenterologist. Participants completed the childhood trauma, emotion regulation, and Object Relations questionnaire. Data were analyzed by Pearson correlation coefficient and simple regression statistical methods.

Results:

 The results of the study showed that the total score of childhood trauma significantly predicts poor emotion regulation in the subscales of depression (P <0.01), and anxiety (P <0.05), as well as the subscales of object relations including egocentrism (P <0.01), alienation (P <0.01), incompetency (P <0.01), and attachment (P <0.05).

Conclusion:

 It can be inferred from the research findings that traumatic childhood experiences, especially emotional experiences, play a decisive role in emotion regulation and object relations of patients with irritable bowel syndrome. Therefore, special attention should be paid to the prevention and treatment programs of these patients.

In order to investigate the resistance level ofannual ryegrass (Lolium rigidum) biotypes to Pinoxaden herbicide, greenhouse and Petri dish bioassay studies based on CRD with 4 replications were conducted at Weed Research Department of Iranian Research Institute of plant Protection during 2008 and 2009. The resistance level of biotypes was determined in pot trials, while the herbicide dose required for 50% reduction of coleoptile length of the susceptible biotypes (GR50) as well as the susceptibility and resistance level of biotypes were studied in Petri dish bioassay trials. The experiments were conducted on 12 annual ryegrass biotypes collected from wheat fields of Fars province. The susceptible (FS) and 11 suspected to resistant biotypes (including ES1, ES2, ES3, ES4, ES5, M1, M2, M3, F1, FJ and FI2) were sprayed at 2- to 4-leaf stage by applying 0-32 times of recommended dose of Pinoxaden herbicide including 0. 45, 90, 180, 360, 720 and 1440 g ai ha-1 in greenhouse experiments. The germinated seeds were also exposed to 0, 0.4, 0.8, 1.6, 3.2, 6.4 and 12.8 g ai l-1 in Petri dish bioassay experiments. The percentage of dry matter and plant survival of each biotype was calculated compared to the untreated control and the resistance level was determined four weeks after herbicide application in greenhouse experiments. The percentage of coleoptile length of biotypes compared to the control was assessed 7 days after treating the germinated seeds with herbicide in Petri dish bioassays and the resistance level of biotypes were calculated. The results of greenhouse and Petri dish bioassay studies indicated that 4 biotypes including ES4, M2, F1 and FJ were resistant to Pinoxaden herbicide. As a general conclusion, most of the studied biotypes were sensitive pionoxaden.