فهرست مطالب zakieh ghorbanpour

Tramadol intoxication and its non-therapeutical abuse have recently become prevalent in Iran. Tramadol overdose cases may be complicated by some neurologic incidences such as seizure. In this study, we aimed to evaluate possible central neural system lesions in patients with tramadol-induced seizure using MRI imaging.
A cross-sectional study was conducted with age- and sex-matched case and control groups. The case group included oral tramadol intoxication cases with loss of consciousness and/or tramadol induced seizure. The control group included patients with seizure without tramadol consumption. The brain MRI was done in the first post-seizure 24-hour. Finally, all data were analyzed using SPSS software.
15 patients (7 females and 8 males) were in the control group and 15 patients (3 females and 12 males) were in the case group with mean age of 22.27±6.54 and 21.93±4.57 years, respectively. 8 patients of case group and 3 patients of control group had abnormal evidence (hyper signal foci in white matter) in brain MRI images; there was no significant difference between the two groups (P=0.128). Lesions depth in MRI images of the case group were equally in Subcortical and Deep parts of the white matter (37.5%) and in 2 cases (25%) were observed in both parts. There was no difference between the two groups in this regard (P=0.721).
In our study, over half of the case group patients had hypersignal but nonspecific evidence in MRI imaging. No significant difference was observed between case and control groups in the lesions pattern.

Comparison of albumin and cabergoline in the prevention of OHSS. 95 high risk infertile women for OHSS (more than 20 follicles in both ovaries at day of Human Chorionic Gonadotropin (HCG) injection) were randomly divided into two groups. First group including 48 women received 10 unit intravenous albumin at starting oocyte retrieval, and second group including 47 women received 0.5 mg/day dopamine agonist (Cabergolin) at day of HCG injection till 8 days. The dosage of human Menopausal Gonadotropin (HMG) used, total number of follicles developed, number of oocytes retrieved, serum E2 concentrations during the luteal phase, development of ascites, number of embryos generated, clinical pregnancy rate, results of the in vitro fertilization-embryo transfer (IVF-ET) cycles and incidence and severity of any OHSS were evaluated. There was evidence of a statistically significant reduction in the incidence of OHSS in the cabergolin group (53.7%) versus albumin group (46.3%) (p=0.04). But there was no significant difference of a reduction in severe OHSS (p=0.62). There was no difference in clinical pregnancy rate too. Administration of cabergolin can prevent incidence of OHSS and does not appear to effect on its severity. Ovarian hyperstimulation syndrome (OHSS) is the most serious and potentially life-threatening iatrogenic complication associated with ovarian stimulation during Assisted Reproductive Technology (ART) protocols. OHSS typically is a result of ovarian expression of vascular endothelial growth factor (VEGF) which increases vascular permeability.