جستجوی مقالات مرتبط با کلیدواژه "angptl4" در نشریات گروه "تربیت بدنی"

The aim of this study was to investigate the effect of eight weeks of high intensity interval training (HIIT) and Portulaca Oleracea extract on Angiopoietin-like 4 Protein (ANGPTL4) level and insulin resistance in rats with NAFLD. Twenty five male Wistar rats were randomly divided into five groups: healthy control, fatty liver control, HIIT, Portulaca Oleracea extract, and HIIT+Portulaca Oleracea extract. To induce NAFLD, the rats were fed a high-fat diet for 12 weeks. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for 8 weeks, 5 sessions per week at 90% maximum speed. Hepatic ANGPTL4 level and insulin resistance were measured after 8 weeks of HIIT and consumption of purslane extract. One way anova and tukey post hoc test was used for data analysis. Insulin resistance was significantly higher in fatty liver control group than healthy controls (P=0.002). But it was significantly lower in HIIT group (P=0.01), Portulaca Oleracea extract (P=0.037), and HIIT+Portulaca Oleracea extract group (P=0.012) than that in fatty liver control group. ANGPTL4 levels in the healthy control group was significantly higher than fatty liver control group (p=0.01). levels of this index in HIIT group (p=0.036), Portulaca Oleracea extract (p=0.01) and HIIT+ Portulaca Oleracea extract (p=0.007) was significantly lower than the fatty liver control group. It seems that HIIT and Portulaca Oleracea extract can play an important role in controlling the progression of this disease by reducing the level of ANGPTL4 and insulin resistance in patients with NAFLD.

BAIBA regulates lipid and carbohydrate metabolism in adipose tissue, liver, and skeletal muscle, and ANGPTL4 plays a role in lipid metabolism and modulates metabolic control. The method of this research was semi-experimental and the statistical population was men suffering from metabolic syndrome in Ardabil city, 20 of them were selected based on inclusion and randomly divided into two groups of exercise (n = 10) and control (n = 10). Aerobic exercise protocol was performed for 12 weeks, three sessions a week and each session lasted 45 minutes with an intensity of 60 to 70% of maximum heart rate. Blood samples were collected in pre- and post-exercise conditions to measure blood variables. .The results showed that after training intervention, the amounts of BAIBA (p = 0.001), VO2 max (p = 0.001) and HDL (p = 0.001) significantly increased, and ANGPTL4 (p = 0.001), BF (p = 0.001), BMI (P = 0.033), waist size (p = 0.01), TG (p = 0.015) LDL (p = 0.009), TC (p = 0.033) and insulin (p = 0.001) had a significant decrease in the exercise group compared to the control group (p≥0.05). Due to its positive effect of aerobic exercise on serum levels of ANGPTL4, BAIBA and factors related to metabolic risk, can be suggested as a method to activate the pathway of converting white to brown fat and improve the indicators related to metabolic risk for men with metabolic syndrome.

Some hepatokines e.g. Fetuin-A, ANGPTL4 and FGF21 are considered as potential factors for type 2 diabetes disorders treatment. The aim of this study was to investigate effects of 12 weeks of aquatic exercise on some serum fetuin-A, ANGPTL4 and FGF21 levels in obese women with type 2 diabetes.

For this purpose, 44 diabetic women aged 50-60 years with a body mass index higher than 25 kg / m2 were randomly divided into two groups of control (n = 22) and water exercise (n = 22). The training group performed underwater exercises for 12 weeks three sessions a week at 75-60% of MHR. The control group followed the normal process of daily activities. Blood samples were collected before and after exercise. Fasting serum glucose, insulin, plasma hemoglobin, fetuin-A, angiopoietin-4, fibroblast growth factor-21, and lipid profile to calculate insulin resistance index. Data were analyzed using ANCOA test.

Serum levels of FBS, HbA1C, fetuin-A, ANGPTL4, fat percentage, insulin and insulin resistance in the experimental group decreased significantly after 12 weeks of water training compared to the control group (p<0.05). Also, exercise in water significantly increased FGF21 levels in the experimental group compared to the control group (p<0.05). Exercise in water significantly reduced TC, TG and LDL indices in the experimental group (p<0.05); But the increase in HDL was not significant (p = 0.21).

It seems that aquatic could reduce diabetes complications.