جستجوی مقالات مرتبط با کلیدواژه "hawthorn" در نشریات گروه "تربیت بدنی"

Alzheimer's disease is a neurodegenerative disease that gradually destroys memory and cognitive skills. The present study was conducted to investigate the effect of twelve weeks of endurance training along with hawthorn consumption on some oxidative stress indicators in the serum of Alzheimer's male rats. In this experimental research, 30 male Wistar rats were randomly divided into 5 groups. Healthy control, Alzheimer's control, Alzheimer's and endurance training, Alzheimer's and endurance training with hawthorn consumption, and Alzheimer's with hawthorn consumption were divided. Endurance training groups (swimming) trained for 12 weeks, 5 days a week and each session started for 15 minutes and up to two sessions of 60 minutes a day. The supplement receiving group received the mixture of hawthorn powder with the standard food of mice at a ratio of 6.25% of hawthorn powder. 24 hours after the last training intervention, the rats were unconscious and the serum levels of SOD, GPX, TAC and MAD were determined by Eliezer method. In order to estimate the desired indicators (superoxide dismutase enzyme, glutathione peroxidase enzyme, total antioxidant capacity and malondialdehyde), blood sampling was done from the inferior vein of rats. The SPSS 22 software and one-way ANOVA test followed by Tukey's post hoc test with a significant level of p≤0.05 were used to analyze the data. The results showed that endurance training, especially at the same time as hawthorn consumption, led to a significant increase in serum levels of glutathione peroxidase compared to other groups (P = 0.002). However, there was no significant change in the serum level of superoxide dismutase (P = 0.129), total antioxidant capacity (P = 0.156) and malondialdehyde (P = 0.498) in the control and experimental groups. Considering that the first line of defense against oxygen toxicity is superoxide dismutase, and to complete the process of eliminating hydrogen peroxide, the enzymes catalase and glutathione peroxidase must be helped. As a result, it can be said that in this study, superoxide dismutase, like glutathione peroxidase, was increased, but no significant difference was observed between the groups in the statistical results.Using hawthorn extract and performing endurance exercises during the week, at moderate intensity and in a regular and intermittent manner, can lead to a reduction in oxidative stress due to an increase in serum levels of total antioxidant capacity and first and second line defense enzymes (superoxide dismutase and glutathione). peroxidase and decrease the serum level of malondialdehyde in Alzheimer's experimental model, based on the results of this study and reviewed previous studies, these models can be suggested as side treatment in Alzheimer's patients, especially in the early stages.

Alzheimer's disease is a neurodegenerative disease. The present study was conducted to investigate the effect of twelve weeks of resistance training along with hawthorn consumption on some oxidative stress indicators in the serum of Alzheimer's male rats.

In this study, 30 male Wistar rats were randomly divided into five groups of six. Healthy control, Alzheimer's control, Alzheimer's disease under resistance training, Alzheimer's disease under resistance training with hawthorn consumption, and Alzheimer's disease with hawthorn consumption were divided. Training was for 12 weeks and 5 days a week in the form of climbing a one-meter long ladder with weights attached to the rats' tails.The weight attached to the tail of each animal reached 50-60%in the first week and140-150%of the mice's weight in the last weeks.The group receiving the supplement received the mixture of hawthorn powder with the standard food of mice at a ratio of6.25%of hawthorn powder.24 hours after the last civilizing and supplemental intervention,the mice were unconscious and the serum levels of SOD,GPX,TACand MAD were determined by Eliezer method.

The results showed that resistance training, especially when taking hawthorn, led to a significant increase (P=0.002) in the serum level of glutathione peroxidase compared to other groups. However, no significant change was observed in the serum level of superoxide dismutase enzyme, total antioxidant capacity and lipid peroxidation in the experimental and control groups.

It is possible that resistance training and supplementation with hawthorn can be effective in adjunctive treatment in Alzheimer's patients, especially in the early stages.