جستجوی مقالات مرتبط با کلیدواژه « عصاره دارچین » در نشریات گروه « تربیت بدنی »

Angiogenesis refers to the formation of new blood vessels from existing vessels, which is an important event in various physiological processes. In this study, the role of exercise along with the consumption of cinnamon bark extract on the expression of important genes in angiogenesis in diabetic male rats was examined.

In this study, 24 diabetic male rats (50 mg/kg streptozotocin (STZ)) with 180-220-gram weight and 8-10 weeks old, were randomly divided into four groups, consisting of 1- Control diabetic (CD), 2-Diabetic+cinnamon (D+CZ), 3- Diabetic+exercise (D+E), 4- Diabetic+cinnamon+exercise (D+CZ+E). To investigate the effect of diabetes induction on research variables, six rats were in the healthy control group. Then groups three and four trained for eight weeks, five sessions per week and each session for 10-30 minutes at a speed of 10-18 meters per minute and Groups two and five received 200 mg / kg of cinnamon extract daily by gavage. One-way analysis of variance and Tukey's post hoc test in SPSS software version 22 software were used to analyze the data (P ≥ 0.05).

endothelin-1 (P ≥ 0.05) and eNOS (P ≥ 0.05) gene expression in the diabetic control group were significantly higher than the healthy control group. eNOS and VEGF levels in the exercise group, cinnamon consumption group and endurance training group + cinnamon were not significantly different from the diabetic control group (P ≤ 0.05). But endothelin-1 levels in the endurance training + cinnamon group were higher than the diabetic control group (P ≥ 0.05).

Endurance training and cinnamon bark extract with the present study method amount do not have a significant effect on some angiogenesis markers in the heart tissue of diabetic rats, although due to limited information on the mechanism of the effect of streptozotocin on angiogenesis in Cardiac tissue further studies are needed in this area.

Insulin resistance is a major factor in the development of type 2 diabetes. Some adipokines have effect on insulin resistance, the most important of these adipokines is resistin. The aim of
this study was to determine the effect aerobic training with cinnamon extract on supplementation resistin and glycemic indexes in rats with insulin-resistant. Thirty-six wistar rats selected and randomly divided into four groups (control, training, cinnamon, and training-cinnamon). Training protocol performed for 8 weeks and 5 days a week with
75-80% VO2max. Cinnamon and training - cinnamon group were injected 200 ml/kg/day cinnamon extract. 72 hours after the final training session blood samples were collected. Data were analyzed using one-way ANOVA at the significant level P≤0.05. The results showed that resistin levels lower significantly in training, cinnamon and cinnamon-training groups compared to control group (P=0.002). Insulin and insulin-resistance
significantly low in training and training–cinnamon groups compared to control group (P=0.001, P=0.005 respectively). Also, glucose levels lower significantly in training–cinnamon group  comparedto control group (P=0.008). According to the findings, it seems aerobic training; cinnamon extract supplementation and combination of these can through the effect on resistin adipokine, have an effect on insulin resistance. It seems to improve insulin action and insulin resistance mediation by reducing adipokines like resistin. It is likely that a combination of aerobic training and consumption of cinnamon extract can be considered for improve insulin resistance as a preventive approach to reduce the production of resistin.

Lipocalin-2 and interleukin-1 beta (IL-1ß) are two inflammatory markers affecting on insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on blood levels of Lipocalin-2 and IL-1ß in insulin-resistant rats. : In this experimental study thirty-six Wistar male rats were randomly divided into four groups: control (n=9), aerobic training (n=9), cinnamon (n=9), and aerobic training+cinnamon (n=9). Insulin-resistance status induced by %10 fructose solutions during 5 weeks. Training groups subjected to a 5-day per week aerobic training program (with 75-80% VO2max) for 8 weeks. Supplementayion groups subjected to injected 200 ml/kg/day cinnamon extract. Exercise training significantly reduced Lipocalin-2 compared to the control group, and compared to extract group (P<0.05). Also, in all three experimental groups, IL-1 beta decreased significantly compared to control (P<0.05), and significant decrease was observed in the extract group compared to the training group and extract (P Results of this study indicated that aerobic training with cinnamon extract more than any of them alone effects on reduction IL-1ß. But the effect of the combination of aerobic training and cinnamon extract on lipocalin-2 requires further investigation.