جستجوی مقالات مرتبط با کلیدواژه "antibacterial activity" در نشریات گروه "علوم پایه"

Bis-phosphonic acid and bis-phosphonate derivatives are a diverse group of natural and synthetic compounds, they exhibit interesting physiological activities and are therefore considered as potential therapeutics in modern medicine. They have found applications as antibacterial, antiviral and as anti-osteoporosis drugs. The present work deals with the preparation of novel Schiff base derivatives linked to inorganic bis-phosphonate groups by reacting the parent compound: Bisphosphonic acid (4-aminophenyl) (hydroxyl) methylene (2) with a variety of aldehydes and ketones. The parent reactant and its condensation products (3a-3j) were identified by physical and spectroscopic techniques, namely; FT-IR, 1H-, 13C-, and 31P-NMR. The antibacterial activity of these derivatives were studied by disk diffusion method and found to possess high in vitro antimicrobial activity against gram-positive and gram-negative bacteria viz. Staphylococcus aureus, Bacillus anthraces, Escherichia coli and Acinetobacter species, referenced to azithromycin and levofloxacin.

Wound infection can cause delayed wound healing, and due to the emergence of antibiotic resistance, treatment of wound infection has become less effective using conventional antibiotics. This has led to the search for an alternative treatment method, which ethnomedicine has proven to be promising. Thus, the antibacterial activity of Senna occidentalis leaf extract was evaluated against isolated bacteria from the wound of patients attending Kwararafa Hospital Wukari, Taraba State, Nigeria. A total of three (3) wounds were randomly swabbed. Bacteria were isolated and identified using standard microbiological procedures. The disk diffusion method was used to assess the antibacterial activity of the aqueous and methanolic extracts of Senna occidentalis leaf extract at different concentrations (20 mg/ml, 40 mg/ml, 60 mg/ml, 80 mg/ml, and 100 mg/ml). The bacteria pathogens isolated and identified are Staphylococcus spp. 3(37.5%), Klebsiella pneumonia 2(25%), Escherichia coli 2 (25%), and Pseudomonas aeruginosa 1(12.5%). The aqueous extract was not effective, while the methanolic leaf extract of the plant displayed promising antibacterial activity at all concentrations against all the bacterial isolates, with the highest zones of inhibition recorded at 100mg/mL, measuring 16±5.0mm, 18±5.0 mm, 20±5.0 mm, and 15±0.0 mm, for Staphylococcus spp., Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa respectively. The result of this study supports the traditional use of Senna occidentalis in the treatment of wound infections.

Some amide derivatives of drugs containing a carboxyl group (Diclofenac¸ ketoprofen, oxaprozin, and naproxen) were prepared with one of the aniline derivatives. The effective method for preparing amides involves coupling amines with carboxylic acids utilizing dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP) under ordinary temperature conditions. The antioxidant activity was evaluated with the 2X08 protein. The results of molecular docking confirmed the biological activity of the prepared compounds and derivative 3 (N-(4-chlorophenyl)-2-((2,6 dichlorophenyl)amino)benzamide) showed high inhibitory activity according to the (Phosphomolybdate assay) method. The other synthesized derivatives exhibited varying degrees of inhibition compared to ascorbic acid. Additionally, the antibacterial (Escherichia Coli) and antifungal (Candida albicans) activities of the prepared compounds were evaluated. The derivatives showed high to moderate activity compared to the standard references (cephalexin and fluconazole), with compound 2 showing significant activity against both bacteria and fungi. All the synthesized compounds were characterizedˮ using FT-IR, ¹H-NMR, 13C-NMR and molecular docking studies.

Ag/PEG/PVA nanocomposites were synthesized using the electrochemical method, in which silver nanoparticles (AgNPs) were incorporated into PEG/PVAmatrices at different time intervals (0, 4, 7, 10, and 13 minutes). Analysis using transmission electron microscopy (TEM) and X-ray diffraction analysis (XRD) absorbance measurements confirmed the bonding of AgNPs to the PEG/PVAmatrix that shows the fact that longer growth times provide more opportunities for silver nanoparticles to aggregate. In addition, the analysis using X-ray diffraction showed that the AgNPs had a structure with face-centered cubic structure. In the last part of this study, synthesized nanocomposites showed strong antibacterial properties against E.coli and Staphylococcus aureus, with a large inhibition zone of 68 mm.

The novel ligand ((E)-2-((4-methoxybenzyl)imino)methyl)-4-methylphenol) and its Cu(II) metal complex were synthesized and extensively studied using NMR, FT-IR, and UV-Visible spectroscopy. The study found d-d transitions (2Eg → 2T2g) in a Cu(II) complex with a tetragonal distortion geometry. The magnetic moments of the copper(II) complex range between 1.78 and 1.92 B.M., indicating the presence of mononuclear Cu(II). Density functional theory validated the molecular structure of the prepared complexes at the B3LYP functional and B3LYP/6-31+G (d, p) levels. Analyzing the charge distribution and molecular orbitals allowed us to predict the quantum chemical properties of these complexes. We investigated the antifungal and antibacterial activity of the ligand and metal complex, and the results indicate that the copper metal complex is more effective than the ligand.

Wastewater containing toxic compounds poses health hazards to living beings. Current researchfocuses on the degradation of malachite green (MG) as a hazardous pollutant dye by using tirescrap-derived activated carbon (AC) to develop nanocomposites with ZnO by hydrothermal method.The morphology, crystal quality, electrochemical active surface area (ECSA), EIS, antibacterialactivity, and optical and photo luminance aspects were studied. The morphology was studiedby SEM. The crystalline and elemental composition study was performed using XRD and FTIR,respectively. UV-visible spectroscopy and photoluminescence were employed for optical studies.The ZnO@C nanocomposite exhibited a nanorod-like shape and hexagonal phase. The role of ACin ZnO@C composite was investigated for the removal of MG under UV illumination. Resultsexhibited that the degradation rate for MG was highly dependent upon dye concentration and pH.Furthermore, an antibacterial study was performed on the nanocomposites. A significant reductionin the band gap (12.6%) was achieved with excellent degradation efficiency of 100%. These resultssuggest that tire scrap waste could produce a new class of carbon materials for various applications,especially in the energy, environment, and biomedical sectors.

2,3-butandionemonoxime and 2-amino-4-nitrophenol were condensed to produce a novel Schiff base ligand (2E,3E)-3-((2-hydroxy-5-nitrophenyl) imion) butan-2-one oxime. In molar ratios of 1:1 and 1:2, Cobalt (II), Nickel (II), Copper (II), Palladium (II), and Platinum (II) complexes have been synthesized by reacting the ligand with metal chloride salts to obtain [Ml. Cl2] and [Ml2.Cl2] complexes. Elemental analysis (C. H. N.), molar conductivity, magnetic susceptibility, and spectral (FT-IR, 13C, 1H-NMR,1H-1H 2D-NMR (NOE), GC-MS, UV-Visible, and stoichiometry analysis Job`s method) studies were used to characterize all synthesized compounds; the ligand exhibits the formation of a new azomethine (C=N) group, and the Ni(II), Pd(II), and Pt(II) complexes screened as a square planer structure, whereas the Co(II) complex showed as a low-spin octahedral and the Cu(II) complex as a distortion octahedral. The antibacterial activity of the starting material, ligand, and complexes has been examined using the good diffusion method against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. According to the activity data, metal complexes and ligands are more active than the starting material, especially the Co(II) complex. Pt (II) complex exhibits the lowest MICs of all the prepared compounds. In this research, we used SEM and EDX methods to investigate the surface properties of the Co (II) complex, which have been particles of nanosize and shape.

In this study, some of new linear and cyclic formazans based on trimethoprim were synthesized through the reaction of diazonium salt with imine carbanions, to produce target compounds. All of the synthesized compounds were obtained through the convenient and mild conditions with good to high yields and characterized by 1H NMR, 13C NMR, CHNS and FT-IR techniques. The biological activity of products was evaluated against gram-positive and gram-negative bacteria. Obtained results shown the considerable inhibition against the gram-negative bacteria.

The alkylation of 5-(((4-bromophenyl) (3,4,5-trimethoxybenzyl) amino) methyl)-1,3,4-oxadiazole-2(3H)-thione was successfully achieved through an alkylation reaction in absolute ethanol. Six alkyl halides were utilized in K2CO3 (anhydrous) medium at room temperature. 1H NMR, 13C NMR, FTIR and EIMs are used to characterize the resulting compounds. Antibacterial activity assay was conducted on all compounds against S. aureus and E. coli bacteria which displayed significant antibacterial activities. Molecular docking was employed to prioritize compounds for assessing their potential to bind to the target of interest. Each compound exhibited a significant decrease in binding free energy (ΔG) compared to the co-crystallized ligand (human PPARα agonist). The heterocyclic compounds demonstrated an effect on peroxisome proliferator-activated alpha receptors, which are utilized in the treatment of hyperlipidemia. Consequently, the synthetic compounds containing a thioalkyl group, a para-bromobenzene group, as well as a 3,4,5-trimethoxybenzyl group, exhibited an enhanced activity on PPARα receptors.

At present, the escalating magnitude of waste represents a formidable global concern, wherein paper waste alone constitutes approximately 26% of the overall waste deposited in landfills. Thus, the transformation of paper waste into viable products assumes paramount significance. In this study, paper waste was converted to CaCO3 using a thermal process and surface-modified with stearic acid. The effect of environmental pH and process temperature on the crystalline structure and morphology of the product was evaluated. The prepared CaCO3 was used to deactivate gram-negative agrobacterium tumefaciens and hydrophobicity's effect on the CaCO3 antibacterial activity was studied. XRD, SEM, FT-IR, BET/BJH, contact angle, and TEM characterization techniques were utilized to characterize the structure and physicochemical properties of prepared CaCO3. According to the XRD analysis, the optimal temperature for the conversion process was 500°C in an air environment without any changes in pH. SEM analysis confirmed that as the calcination temperature increased, the number of cracks and holes on the surface also increased. BET analysis confirmed this by showing a decrease in the specific surface area in the Ca-750 sample. TEM analysis revealed nanoparticles with spherical and irregular spherical geometries, ranging in size from 30 to 90 nm. According to the contact angle analysis, increasing the concentration of stearic acid led to an increase in the contact angle to 121.4°. This increase in contact angle indicates an enhancement in the hydrophobicity of the prepared nanoparticles, which had a synergistic effect on their antibacterial activity. The antibacterial activity test of both prepared hydrophilic and hydrophobic CaCO3 depicted the high antibacterial activity of both CaCO3 while the hydrophobic CaCO3 revealed higher antibacterial activity compared to hydrophilic CaCO3.

In this work, novel antibacterial drugs that are tetrazole derivatives connected to the 1-position of the heterocyclic ring (benzimidazole) via a methyl bridge were designed and synthesized. The final chemical structures of the prepared tetrazole derivatives were confirmed by nuclear magnetic resonance (1H NMR and 13C NMR), and Fourier-transform infrared spectroscopy (FTIR) spectroscopy. Three types of Candida were used to investigate the synthetic compounds' antifungal properties: Candida albicans, Candida glabrata, and Candida parapsilosis. Compounds e1 and b1 have greater efficacy against Candida albicans than normal fluconazole, while compound d1 shows greater efficacy against Candida glabrata. The ability of compounds to combat gram-positive and gram-negative, Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis was also assessed. The lowest inhibitory concentrations of compounds e1, b1, and c1 against E. faecalis were comparable to those of the control drug azithromycin. Modeling studies were conducted against the 14-α demethylase enzyme found in Candida species. When it came to combating Candida species, e1 was the most effective chemical and had the highest docking contact energy. Based on the theoretical ADME of prepared compounds calculated, the molecule profiles meet the limitation rule requirements.

This work represents a green synthesis of Lanthanum and Cerium oxide nanoparticles (NPs) using Azadirachta Indica (Neem) leaf extract. La2O3 and CeO2 NPs were characterized for purity and structural properties using different techniques such as Ultra Violet-Visible (UV-Visible), Fourier Transform Infra-Red (FT-IR), X-ray Diffraction (XRD) and Brunauer–Emmett–Teller (BET) analysis. Scanning Electron Microscopy (SEM) and High-Resolution Transmission Electron Microscopy (HRTEM) reveal a spherical shape having an average size of 10-50 nm. BET analysis shows an increment of surface area from 14.909 m2/g to 42.144 m2/g. The peak pore volume of metal oxide nanoparticles increases from 0.181 cm3/g to 0.2338 cm3/g. Further, synthesized NPs were analyzed for dielectric behavior, antibacterial studies, and hemolysis assay.

Isoniazid is identified as isonicotinylhydrazide (INH) and its derivatives comprising N-containing heterocyclic compounds encompass gained importance in therapeutic chemistry due to their assorted natal bustle such as opposed to mycobacteria, antibacterial, antivirus, antifungal, anti-tumor, and analgesic activities. This complex involves of two isoniazid molecules (INH), six hydrated molecules, and two perchlorate chlorates for each metal center (C12H26N6Cl2O16Ni). Nickel (II) is two-component coordinated by two INH molecules via hydrazide groups (N and O) and two other isoniazids via an aromatic nitrogen atom into the nickel (II) coordination sphere. Tuberculosis is a serious infection and one of the drugs used to prevent and treat its isoniazid (INH). A current study examined the method of accomplishment of isoniazid (INH), an important chemotheraphatic agent of tuberculosis, and also estimated dead set against-mycobacterial potential of isoniazid derivatives. We interested to compile intelligences on various isoniazid derivatives with described various biological activities such as opposed to mycobacterial, bacterial, fungal and viral activity. This study investigates the synthesis and characterization of a novel nickel (II) complex derived from 5-acetyl-N-(adamantan-2-yl) thiophene-2-carboxamide, aimed at enhancing the efficacy of isoniazid in combating bacterial infections, cancer, and tuberculosis. The complex was synthesized using a facile method and characterized through various analytical techniques, including spectroscopic and elemental analyses. Results revealed that the nickel (II) complex exhibited enhanced efficacy against bacterial strains, cancer cells and Mycobacterium tuberculosis, suggesting its potential as a multifunctional therapeutic agent.

Here, to assess the chemical composition and antibacterial/antioxidant effects of the essential oils of eucalyptus, the young leaves of eucalyptus trees (Eucalyptus camaldulensis) cultivated in Shushtar city (Khuzestan Province, Iran) were utilized in the late spring season of 2024. The essential oil extraction was carried out using the water distillation method, resulting in a 2% yield based on the dry weight of the leaves. Gas chromatography-mass spectrometry (GC-MS) analysis of the essential oil indicated the presence of (S,E)-2,5-Dimethyl-4-vinylhexa-2,5-dien-1-yl acetate, alpha-terpinene, and (-)-Globulol as the major components, accounting for 17.63%, 9.97%, and 6.23% of the total composition, respectively. Further DPPH assay testing showed a concentration-dependent inhibitory effect, with the highest concentration (0.80 mg/ml) exhibiting an impressive 93.62% inhibition. According to the ANOVA results, a significant difference was observed among all nine treatments (multiplying by three different essential oil concentrations of 0.2, 0.4, and 0.8 mg/mL and three different bacterial agents of S. aureus, B. cereus, and E. coli) in terms of inhibition zone recorded using the agar well diffusion method. The largest inhibition zones were observed for three treatments of "0.8 mg/mL + B. cereus", "0.4 mg/mL + S. aureus", and "0.8 mg/mL + S. aureus" with the inhibition zone values of 39.62 mm, 35.37 mm, and 39.11 mm, respectively. On the other hand, the minimum inhibition zone value of 14.02 mm was observed for the "0.2 mg/mL + E. coli" treatment. According to the results, both gram-positive bacteria of S. aureus and S. cereus were more sensitive to the essential oil of E. camaldulensis essential oil than the gram-negative bacteria of E. coli. These current promising results demonstrated the effectiveness of E. camaldulensis essential oil as a natural and eco-friendly alternative for antimicrobial studies.

Plant materials are still a valuable resource for solving global issues. The rising wastewater contamination, particularly the usage of weed plants, continues to be a significant factor in addressing the fundamental techniques required in both developed and developing nations. Recent studies focused on Miscanthus sinensis's capacity to produce biochar for the removal of antibiotics from wastewater. This study intends to assess how well Miscanthus sinensis biochar removes various medicines such as ampicillin, ciprofloxacin, oxytetracycline, penicillin, and streptomycin. Standardization of the antibiotics Ampicillin, Ciprofloxacin, Oxytetracycline, Penicillin, and Streptomycin were investigated. Preparation and functionalization of biochar made from the Miscanthus sinensis plant. To conduct an experiment employing functionalized biochar and a UV spectrophotometric test for antibiotic adsorption. SEM-EDAX (Scanning electron microscopy with energy dispersive X-Ray analyzer), XRD (X-Ray Diffraction), and Thermogravimetric analysis were used to characterize the biochar after the antibiotics were removed from the wastewater. Antibacterial activities are evaluated in research on antibiotic elimination and examining the biochar's capacity for adsorption in antibiotic contamination. They have shown that the adsorbent has a high ability to remove antibiotics such as (Oxytetracycline) from aqueous solutions so that it can remove more than 92% of ampicillin) in less than 2 h from the aqueous solution. This study of single and mixed antibiotics comparison also developed wastewater treatment plants and the five classes of antibiotic adsorption percentages slightly equal to single antibiotic and mixed antibiotics. Further work on the antibiotics mixed process will be performed to develop a wastewater treatment plant soon.

This study assessed the phenolic and flavonoid contents, and antioxidant, antibacterial, as well as cytotoxic properties of the protocorm extract of Dendrobium transparens and compared it to its wild equivalents. Methanol was used to extract compounds from the stems (DTSE) and protocorms (DTPE). DTSE contained 61.889 mg QE and 82.00 mg GAE per gram of quercetin and gallic acid, respectively. At a concentration of 191.23 μg/mL, DTSE exhibited a 50% DPPH radical scavenging efficiency. Compared to the 3T3 cell line (2108.87 μg/mL), the DTPE's cytotoxic ability against the HeLa (229.30 μg/mL) and U251 (213.90 μg/mL) cell lines was found to be significantly stronger. However, the U251 cell line was strongly cytotoxic to DTSE (75.84 μg/mL). At a dose of 2000 mg/kg, neither DTSE nor DTPE caused any discernible harm in mice. They could inhibit the growth of Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. Based upon the experimental results, the wild stems and protocorms were found to be alternatives suitable for creating pharmacologically bioactive substances.

A synergistic effect of gold nanoparticles and curcumin and a unique combination of chitosan natural amphiphilic polymer due to their widespread biological and technological applications have gained much attention. Their simpler synthesis for encapsulating curcumin-conjugated gold nanoparticles in particulate carriers assembled by polymer as trapping agent via green chemistry has also become of foremost importance. The current study offers to report a new, simple, single-step, and cost-effective room temperature strategy for the fabrication of curcumin-conjugated spherical gold nanoparticles dispersed on the surface of chitosan by pH adjusting that curcumin acts as the reducing and stabilizing agent based on the flash nanoprecipitation.  The prepared samples were characterized with UV-Vis, AFM, and TEM analysis. Regarding the obtained data from the antibacterial test by disc diffusion method, the prepared chitosan with high curcumin conjugated gold nanoparticles compared to the pure chitosan and curcumin encapsulated chitosan nanoparticles with high antibacterial activity will open a unique opportunity for industrial scale-up. The inhibition zone diameter was 25 mm which is more than the inhibition zone diameter for chitosan (7 mm) and chitosan with curcumin loading (12 mm).

The use of various plant materials for the synthesis of nanoparticles is considered as green synthesis, which does not involve any harmful chemicals. In this study, silver nanoparticles were synthesized by a fast, one-step method and a green biosynthesis method by regenerating a silver nitrate solution using Oak peel extract containing biomolecule which as a reducing and stabilizing element Suitable to play a role. Effective parameters such as pH of solution, silver nitrate concentration, temperature and contact time were studied and optimized The structure and properties of nanoparticles were determined by spectroscopic absorption analyzes UV-Visible, Scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. According to the Sherer-Debye equation, the size of the nanoparticles was measured 29 nm. Then the antibacterial effect of nanoparticles produced against two strains of pathogenic bacteria, gram positive Staphylococcuas aureus and gram negative Escherichia coli was investigated by disk diffusion and determination of minimum inhibitory concentration(MIC) methods. The results of the antibacterial activities test showed that the nanoparticles produced from Oak Peel had a good effect on both bacteria. The purpose of this research is to synthesis and develop a new method for the preparation of silver nanoparticles using environmental methods.

Aqueous Moringa Oliefiera (MO) leaves extraction is employed as a reductant to generate silver nanoparticles (AgNPs) and silver oxide nanoparticles (Ag2ONPs) in cellulose fabrics by in situ technique. The biosynthesized nanocomposite cotton fabrics (NCFs) were analysed by X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) associated Energy Dispersive X-ray (EDX) spectroscopy, Fourier Transform Infrared (FTIR) and Thermogravimetric analysis (TGA) methods. The shape and mean size of AgNPs in NCFs were found to be globular and 82 nm, respectively and their formation in NCFs was established by SEM studies. EDX analysis established the presence of silver metal. The XRD analysis revealed that the obtained silver based nanoparticles were crystalline in nature. The TG and DTG analysis showed that the obtained NCFs were thermally stable. These NCFs exhibited good antibacterial activity against Gram negative (G-ve) Pseudomonas aeruginosa (P. aeruginosa) and Gram positive (G+ve) Staphylococcus aureus (S.aureus) bacteria. The mechanical properties such as modulus, tensile strain and stress of NCFs were also tested, utilizing universal testing machine (UTM). The modulus was found to be 276.4 MPa. These NCFs can be used in medicine for making antibacterial napkins, wound dressing bandage cloth, etc., and as packaging materials.