جستجوی مقالات مرتبط با کلیدواژه « antibacterial activity » در نشریات گروه « علوم پایه »

Ag/PEG/PVA nanocomposites were synthesized using the electrochemical method, in which silver nanoparticles (AgNPs) were incorporated into PEG/PVAmatrices at different time intervals (0, 4, 7, 10, and 13 minutes). Analysis using transmission electron microscopy (TEM) and X-ray diffraction analysis (XRD) absorbance measurements confirmed the bonding of AgNPs to the PEG/PVAmatrix that shows the fact that longer growth times provide more opportunities for silver nanoparticles to aggregate. In addition, the analysis using X-ray diffraction showed that the AgNPs had a structure with face-centered cubic structure. In the last part of this study, synthesized nanocomposites showed strong antibacterial properties against E.coli and Staphylococcus aureus, with a large inhibition zone of 68 mm.

The novel ligand ((E)-2-((4-methoxybenzyl)imino)methyl)-4-methylphenol) and its Cu(II) metal complex were synthesized and extensively studied using NMR, FT-IR, and UV-Visible spectroscopy. The study found d-d transitions (2Eg → 2T2g) in a Cu(II) complex with a tetragonal distortion geometry. The magnetic moments of the copper(II) complex range between 1.78 and 1.92 B.M., indicating the presence of mononuclear Cu(II). Density functional theory validated the molecular structure of the prepared complexes at the B3LYP functional and B3LYP/6-31+G (d, p) levels. Analyzing the charge distribution and molecular orbitals allowed us to predict the quantum chemical properties of these complexes. We investigated the antifungal and antibacterial activity of the ligand and metal complex, and the results indicate that the copper metal complex is more effective than the ligand.

This work represents a green synthesis of Lanthanum and Cerium oxide nanoparticles (NPs) using Azadirachta Indica (Neem) leaf extract. La2O3 and CeO2 NPs were characterized for purity and structural properties using different techniques such as Ultra Violet-Visible (UV-Visible), Fourier Transform Infra-Red (FT-IR), X-ray Diffraction (XRD) and Brunauer–Emmett–Teller (BET) analysis. Scanning Electron Microscopy (SEM) and High-Resolution Transmission Electron Microscopy (HRTEM) reveal a spherical shape having an average size of 10-50 nm. BET analysis shows an increment of surface area from 14.909 m2/g to 42.144 m2/g. The peak pore volume of metal oxide nanoparticles increases from 0.181 cm3/g to 0.2338 cm3/g. Further, synthesized NPs were analyzed for dielectric behavior, antibacterial studies, and hemolysis assay.

Isoniazid is identified as isonicotinylhydrazide (INH) and its derivatives comprising N-containing heterocyclic compounds encompass gained importance in therapeutic chemistry due to their assorted natal bustle such as opposed to mycobacteria, antibacterial, antivirus, antifungal, anti-tumor, and analgesic activities. This complex involves of two isoniazid molecules (INH), six hydrated molecules, and two perchlorate chlorates for each metal center (C12H26N6Cl2O16Ni). Nickel (II) is two-component coordinated by two INH molecules via hydrazide groups (N and O) and two other isoniazids via an aromatic nitrogen atom into the nickel (II) coordination sphere. Tuberculosis is a serious infection and one of the drugs used to prevent and treat its isoniazid (INH). A current study examined the method of accomplishment of isoniazid (INH), an important chemotheraphatic agent of tuberculosis, and also estimated dead set against-mycobacterial potential of isoniazid derivatives. We interested to compile intelligences on various isoniazid derivatives with described various biological activities such as opposed to mycobacterial, bacterial, fungal and viral activity. This study investigates the synthesis and characterization of a novel nickel (II) complex derived from 5-acetyl-N-(adamantan-2-yl) thiophene-2-carboxamide, aimed at enhancing the efficacy of isoniazid in combating bacterial infections, cancer, and tuberculosis. The complex was synthesized using a facile method and characterized through various analytical techniques, including spectroscopic and elemental analyses. Results revealed that the nickel (II) complex exhibited enhanced efficacy against bacterial strains, cancer cells and Mycobacterium tuberculosis, suggesting its potential as a multifunctional therapeutic agent.

Plant materials are still a valuable resource for solving global issues. The rising wastewater contamination, particularly the usage of weed plants, continues to be a significant factor in addressing the fundamental techniques required in both developed and developing nations. Recent studies focused on Miscanthus sinensis's capacity to produce biochar for the removal of antibiotics from wastewater. This study intends to assess how well Miscanthus sinensis biochar removes various medicines such as ampicillin, ciprofloxacin, oxytetracycline, penicillin, and streptomycin. Standardization of the antibiotics Ampicillin, Ciprofloxacin, Oxytetracycline, Penicillin, and Streptomycin were investigated. Preparation and functionalization of biochar made from the Miscanthus sinensis plant. To conduct an experiment employing functionalized biochar and a UV spectrophotometric test for antibiotic adsorption. SEM-EDAX (Scanning electron microscopy with energy dispersive X-Ray analyzer), XRD (X-Ray Diffraction), and Thermogravimetric analysis were used to characterize the biochar after the antibiotics were removed from the wastewater. Antibacterial activities are evaluated in research on antibiotic elimination and examining the biochar's capacity for adsorption in antibiotic contamination. They have shown that the adsorbent has a high ability to remove antibiotics such as (Oxytetracycline) from aqueous solutions so that it can remove more than 92% of ampicillin) in less than 2 h from the aqueous solution. This study of single and mixed antibiotics comparison also developed wastewater treatment plants and the five classes of antibiotic adsorption percentages slightly equal to single antibiotic and mixed antibiotics. Further work on the antibiotics mixed process will be performed to develop a wastewater treatment plant soon.

This study assessed the phenolic and flavonoid contents, and antioxidant, antibacterial, as well as cytotoxic properties of the protocorm extract of Dendrobium transparens and compared it to its wild equivalents. Methanol was used to extract compounds from the stems (DTSE) and protocorms (DTPE). DTSE contained 61.889 mg QE and 82.00 mg GAE per gram of quercetin and gallic acid, respectively. At a concentration of 191.23 μg/mL, DTSE exhibited a 50% DPPH radical scavenging efficiency. Compared to the 3T3 cell line (2108.87 μg/mL), the DTPE's cytotoxic ability against the HeLa (229.30 μg/mL) and U251 (213.90 μg/mL) cell lines was found to be significantly stronger. However, the U251 cell line was strongly cytotoxic to DTSE (75.84 μg/mL). At a dose of 2000 mg/kg, neither DTSE nor DTPE caused any discernible harm in mice. They could inhibit the growth of Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. Based upon the experimental results, the wild stems and protocorms were found to be alternatives suitable for creating pharmacologically bioactive substances.

The application of Sterculia as a catalyst in the synthesis of chalcone derivatives and the green, ecologically friendly technique of MgO particles are discussed in this work. The XRD, EDAX, FTIR, and UV methods were used to analyse bio-derived MgO particles. Chalcones were prepared as antimicrobial agents using the Claisen-Schmidt condensation of 1-(4-fluoro-3-methylphenyl)ethan-1-one with aromatic aldehydes in the presence of Sterculia catalyst. The developed substances were identified using their UV, FT-IR, mass, and 1H-NMR spectrum data, as well as elemental analysis. An appealing characteristic of the process is the one-step condensation of substituted aryl carbonyls, which allows for the synthesis of substituted chalcones in less than 3 minutes under solvent-free conditions and microwave irradiation, with a yield of 85-95%. The critical advantages of our study are the short period and the extraordinary output of substituted chalcones. The disc diffusion method was utilized to assess the antibacterial and antifungal characteristics of all synthesized chalcones against two-gram positive and two-gram negative bacteria, as well as two fungicides.

The utilization of silver nanoparticles (AgNPs) in diverse fields, including medicine, is on the rise, leading to the development of a non-toxic and environmentally friendly synthesis method. This study presents a straightforward and stable one-step synthesis of AgNPs using an aqueous extract of Amygdalus lycioides as both a reducing and stabilizing agent. The experimental findings demonstrated that the presence of Amygdalus lycioides extract results in the formation of AgNPs with smaller size, uniformity, and well-dispersed nanostructures. The synthesis process is significantly influenced by certain reaction parameters such as the molar ratio of AgNO3, temperature, and extract volume. Characterization of the nanostructures was performed using XRD, UV-Vis, FT-IR, DLS, and SEM measurements. Furthermore, the AgNPs exhibited potent antibacterial effects, leading to cell death through increasing the membrane permeability and disrupting bacterial wall integrity. Additionally, this research explores the fungicidal characteristics of the colloidal solution of nanosized silver as a potential antifungal treatment against various plant pathogens. Based on the obtained results, AgNPs exhibit varying levels of antifungal activity against these plant pathogens. Molecular docking calculations revealed the binding energy between Ag metal and bacteria. These findings pave the way for effective and novel antimicrobial therapies as alternatives to traditional antifungal and antibacterial drugs, thereby addressing the challenges of microbial resistance and the difficulty of eradicating infections in the near future.

The plant-based extract can be used to synthesize silver nanoparticles (Ag NPs) as a reducing agent. In the present study, Oregano leaves’ extracts were extracted using ethanol to synthesize Ag NPs. The effects of different parameters such as the processing time, temperature, and stirring rate on the mean particle size, concentration, and zeta potential of the synthesized Ag NPs solutions were optimized using Response Surface Methodology (RSM). At the optimum condition, which includes processing time (30.48 min), temperature (70 ºC), and stirring rate (370.530 RPM), Ag NPs were obtained with 33 nm of the mean particle size, 76.109 ppm of concentration, and +17.2 mV of zeta-potential. In this condition, Ag NPs displayed high antibacterial activity against Gram-negative and Gram-positive bacteria. In addition, the maximum antioxidant activity of 11.7% was obtained at optimum synthesizing conditions.

In the past decade, numerous longitudinal studies have explored green chemistry and its applications in nanoparticle synthesis due to the toxicity associated with traditional methods. Among the various techniques for nanoparticle synthesis, the use of plant extracts in green synthesis has recently gained significant popularity. Green methods are particularly suitable for large-scale nanoparticle synthesis, offering faster preparation rates compared to microorganisms and the ability to produce nanoparticles in diverse sizes and shapes. Nickel oxide nanoparticles (NiO NPs) have been extensively utilized in catalysis, photocatalysis, optics, magnetism, and antibacterial applications. This review focuses on the preparation of NiO NPs using plant extracts, emphasizing their advantageous features such as the absence of contaminant release, environmental friendliness, and cost-effectiveness. Additionally, we delve into the catalytic, photocatalytic, and antibacterial applications of NiO NPs.

Synthetic preservative compounds can prevent pathogenic bacterial growth, but they cause other concerns related to the adverse effect on human health. Essential Oil (EO), which possesses antibacterial activity, have potential replacers for synthetic preservatives. This study was conducted to develop Atlas cedar EO antibacterial activity, physical properties and sustainability against environmental stress via emulsification. Firstly, screening to select the most potent EO among various EOs (i.e. anise, Atlas cedar, curry leaf and onion) was done. As Atlas cedar was the most efficient antibacterial agent, emulsions containing Atlas Cedar EO were subsequently prepared using different concentrations of Polysorbate20 via a solvent-displacement technique. The physical properties (droplets size, stability, lightness and turbidity) and antibacterial activity (agar disk diffusion) of emulsions were determined. Results showed that emulsion containing 7% (wt) of Polysorbate20 was the most desirable sample in terms of physical properties of antibacterial activity. Henceforth, it was selected for environmental stresses study (i.e. thermal processing, freeze-thaw cycle and ultraviolet exposure). Results revealed that all types of environmental stresses had a significant (p<0.05) effects on physical properties. Environmental stress treatments showed antibacterial activity enhancement against Gram-positive bacteria. Thus, the present work proved the potential use of emulsion as the delivery system of EO as antibacterial agent for applications in the food industry.

This study investigated the antibacterial activity of a lectin-like bacteriocin extracted from Pseudomonas putidaisolated from various soil samples in Baghdad. Thirteen new isolates of P. putidawere identified using morphological, physiological, and molecular methods. Real-time PCR identified three isolates carrying the bacteriocin gene. Antibiotic sensitivity was tested on pathogenic bacteria, and one isolate from each species exhibiting broad-spectrum resistance was selected. The crude bacteriocin from 13 isolates showed antimicrobial activity against six pathogenic bacterial species, with five isolates exhibiting inhibition zones. Purification resulted in a bacteriocin with a total protein concentration of ~4669μg/ml and an apparent molecular mass of ≤11 kDa. HPLC confirmed the molecular mass. This study quantified the expression of P. putidabacteriocin genes, characterized as putadicin, with potential applications in human medicine for burn treatment in Iraq.

The current research work was mainly focused on the antibacterial performance of Mn/Mg co-doped TiO2 nanoparticles in presence of Gemini surfactant (GS). Mn, Mg co-doped TiO2 nanoparticles were synthesized by sol-gel method and calcined at 450 0C. The characterization results reveal that among all the co-doped TiO2 and surfactant encapsulated TiO2 nanoparticles, the MMT5-GS2 Nano catalyst exhibited the most favorable properties, featuring a small particle size, a large surface area, with respective values of 6.6 nm, 230.2 m2/g, and a bandgap of 2.66 eV. The efficiency of the synthesized catalysts was examined by the antibacterial activity of Escherichia coli (E. coli) and Klebsiella pneumonia pathogens. Among all the catalysts, MMT5-GS2 demonstrated the best performance. The zone of inhibition of bacterial growth for E. coli and Klebsiella pneumonia was measured to be (33.1±0.12 mm) and (26.1±0.12 mm) respectively, at a concentration of 400 µg/mL. These values are significantly higher than the standard value of (chloramphenicol-16.71±0.2) at 100 µg/mL, indicating the remarkable efficacy of the MMT5-GS2 nanocatalyst. The co-doped nano titania particles encapsulated with surfactant have great potential as antibacterial agents.

In this research, TiO2 nanoparticles were synthesized by sol-gel method and coated on the tile by using the Doctor Blade method. The TiO2 hydrophobic coatings were prepared by applying oleic acid and an organic binder on the tile substrate. The XRD, FESEM, Contact Angle, and FT-IR analyses characterized the manufactured coatings. According to the XRD pattern, the synthesized nanoparticles have good crystallinity, and two anatase and rutile phases have formed. The contact angle analysis showed that the contact angle increased by surface modification by using oleic acid. The antibacterial and photocatalytic activity of the coatings were evaluated in the decomposition of Escherichia Coli in various concentrations of bacteria and various dyes. The results confirmed the good antibacterial and photocatalytic activity of TiO2 coatings. The stability and durability of the coatings were examined by applying the salt spray test, Shore D test, and ultrasonic bath. The coatings revealed good anti-corrosion properties, and the hydrophobicity of the coatings was preserved after the salt spray test.

Ag nanocolloid was prepared by green synthesis method using gum rosin as a capping and reducing agent and silver nitrate (AgNO3). The prepared Ag nanocolloid was characterized by using different analytical techniques such as UV-Vis, Dynamic light scattering (DLS), Zeta potential, Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), and Transmission electron microscopy (TEM). UV–visible spectra of the prepared Ag nanocolloid showed a sharp peak at ∼425 nm corresponding to the surface plasmon resonance (SPR) of the silver nanoparticles that were capped with gum rosin molecules. Ag nanoparticles with a diameter of 15-30 nm were observed in TEM and DLS analysis. A negative zeta potential value of −20.54 mV proved the stability of the rosin-stabilized silver nanoparticles. The Ag nanocolloid has shown an antibacterial activity against model organisms, a gram-negative Escherichia coli NCIM 2931 in Mueller–Hinton (MH) medium, which is hitherto unattempted up to now. In this study the ratio of Minimum Inhibitory (MIC) and Minimum Bactericidal Concentration (MBC) (MIC/MBC) was equal to 1, the green synthesized nanocolloid can be regarded as possessing an antibactericidal performance. The Ag nanocolloid with monodispersed Ag nanoparticles is considered to have potential applications in a variety of fields such as nanosensors, catalysis, electronic devices, and batteries.

In recent years, a strong interest has emerged in hybrid composites and their potential uses, especially in Chitosan Nanoparticle – MontMorillonite - Titanium dioxide - (CSNP – MMT - TiO2) composites, which have interesting technological properties and applications. Using the Precipitation Method, Chitosan Nanoparticles with TiO2 Nanocomposite (CSNP – MMT - TiO2 Nanocomposite) was created. Analysis using Scanning Electron Microscopy (SEM) revealed that the modified TiO2 Nanocomposite was successfully dispersed into the Chitosan matrix and that the roughness of the Chitosan Nanoparticle - MMT- TiO2 Nanocomposites were significantly reduced. Moreover, X-Ray Diffraction (XRD) and Fourier Transform InfraRed (FT-IR) spectroscopy analyses indicated that the Chitosan interacted with TiO2 Nanocomposite and possessed good compatibility, while a ThermoGravimetric Analysis (TGA) of the thermal properties showed that the Chitosan-MMT-TiO2 Nanocomposites with 0.05% TiO2 Nanocomposite concentration had the best thermal stability. The Chitosan- MMT-TiO2 Nanocomposite exhibited an inhibitory effect on the growth of gram-positive and gram-negative microorganisms.