جستجوی مقالات مرتبط با کلیدواژه "biological activity" در نشریات گروه "ریاضی"

DNA sequences rich in Guanine can come together to form G-quadruplexes, which are tetra-stranded structures. According to some theories, these secondary DNA structures may have a role in the control of several important biological processes. The telomere and the promoter regions of several oncogenes contain guanine-rich sequences that have the potential to create G-quadruplexes in the human genome. The aim of the work was to Prepare guanine complexes with metal ions (Cd(II), Fe(II), Cu(II), Zn(II), Cr(III), Fe(III), Pb(II), and Mn(II)). The complexes were characterised by physical chemical and spectroscopic techniques such as electrical conductivity, metal content, infrared, UV-visible and molar conductivity techniques. The molar ratio of Guanine to metal ion reaction is 1:2, which is determined by the molar ratio method. Dissociation constants for guanine ligands were determined spectrophotometrically. The effect of solvents on the electronic spectra of guanine ligands was studied using solvents of different polarities. The biological activity of guanine ligands and their metal complexes was tested in vitro against selected fungal and bacterial species. The results showed satisfactory spectra for the tested organisms.

In present studies the synthesis, characterization and biological properties of oxovanadium(IV) coordination compounds of 4[N-(4′-ethylbenzalidene)amino] antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2′,4′-dimethylbenzalidene)amino] antipyrine thiosemicarbazone (DMBAAPTS) with the general composition VOX2L (X = C1-, Br-, I-, NO3-or NCS-) and VO(CIO4)2(L)H2O (L = EBAAPTS or DMBAAPTS) are described . All the complexes were characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectra. In all these complexes, both the thiosemicarbazones behave as neutral tridentate (N, N, S) ligands. The thermal properties of the representative complexes are also reported. The most probable geometry of the complexes is proposed.