جستجوی مقالات مرتبط با کلیدواژه « استامینوفن » در نشریات گروه « زیست شناسی »

This study was aimed at investigating the effect of aqueous extract of golden wheat flower on acetaminophen-induced liver tissue damage in rats. Forty-two male rats were randomly assigned to seven groups of six (control group and five treatment groups) and kept hungry for 12-16 hours the night before the experiment and all groups were given 600 mg/kg daily for five weeks. Acetaminophen was administered orally. During the experiment, based on the weight of mice, 0.2 ml of wheat flower extract with concentrations of 160, 180, 200, 220, 240, and 260 mg/kg orally and one hour after receiving a toxic dose of acetaminophen. Liver enzymes (AST, ALT, and ALP) were assayed and the liver tissue of mice treated was examined under a light microscope. The results of this study showed that the aqueous extract of golden wheat flower affected the activity of aspartate aminotransferase enzyme and at a dose of 260 significantly decreased (p <0.05) compared to other groups. Besides, the severity of liver damage showed a significant difference between the groups; however, the levels of alkaline phosphatase and alanine aminotransferase did not show a significant difference between different groups. The research results proved the effect of the aqueous extract of golden wheat flower in preventing liver tissue damage following liver poisoning caused by taking acetaminophen.

In this study, the protective effect of Iranian Golpar on the acute hepatotoxicity due to acetaminophen over doses has evaluated. 80 Wistar male rats were randomly divided in to 4 groups (n=5). Control groups used tap water in 14 days following DMSO i.p injection at day 15th. Acetaminophen groups received tap water in 14 days following 500 mg/kg b.w. injection of acetaminophen (i.p) dissolved in DMSO. Treatment groups received Golpar essential oils (100 and 200 mg/kg b.w) in 14 days following acetaminophen injection at day 15th. Then, the concentration of glutathione (GSH), proxidasion lipids (MDA) and the total antioxidant capacity of plasma and the activity of glutathione s-transferase (GST) with biochemical methods were estimated. Indeed, the levels of liver enzymes; alanin Teransferase (ALT), aspartate Teransferase (AST), and alkaline phosphatase ALP of the serum were measured. Hence, the histopathology assessments were performed in the liver. The results of the study showed that the Golpar essential oil could significantly prevent from decreasing of GSH, GST and FRAP and increasing of the liver enzymes and prooxion lipids after severe acetaminophen toxicity. Also, the histopathological findings of the liver tissue was confirmed the above results. Therefore, the Golpar essential oil could remarkably protect the liver tissue against the stress oxidative induced by acetaminophen.

This study was carried out to investigate the hepatoprotective effect of deuterium depleted water with Satureja rechingeri essential oil on liver damage. For this purpose, the adult male rats were divided into 16 groups. The negative control group used tap water in 14 days following DMSO i.p injection at day 15th. The treatment group with acetaminophen received tap water in 14 days following 500mg/kg b.w. i.p injection of acetaminophen dissolved in 300ml DMSO at day 15th. The treatment groups receiving deuterium depleted water (30ppm and 60 ppm) plus i.p injection of Satureja rechingeri essential oil following 500 mg/kg b.w. acetaminophen injection at day 15th.Then, at 4,8,16 and 24 hours after acetaminophen injection, the blood was taken from hurt puncture and the liver tissues were removed. Then, the biochemical marker levels such as AST, ALT, ALP and bilirubin were measured in plasma. The glutathione s-transferase enzyme activity and protein level, cytochrome P450 protein level and glutathione level were also estimated in liver homogenate. Findings indicated no significant changes in the level of serum parameters such as ALT, ALP and bilirubin in groups. While injecting acetaminophen decreased the levels of GST and GSH and increased significantly the level of CYP450 and AST. Treatment with deuterium depleted water and Satureja rechingeri essential oils are effective in moderating the levels of these parameters, leaded to returning of these parameters to normal values. Finally, the treatment of rats with high dose of acetaminophen caused liver oxidative damage and using of deuterium depleted water and Satureja rechingeri essential oil can be effective in preventing and improving these damages.