جستجوی مقالات مرتبط با کلیدواژه « سینامالدهید » در نشریات گروه « زیست شناسی »

The studies showed Bax and Bcl2, as very important genes in the process of apoptosis that can prevent cancer. The role of TGFβ gene has been also proven as a very important gene in the process of invasion and metastasis in cancers. This study aims at evaluating the expression changes of these three very important genes in cancer cells of rat gastric tissue by Dimethylhydrazine. In this study, forty male Wistar rats and 53 weeks old rats were evaluated and were divided into four ten-groups. The control group received only water and food, the second group received carcinogens without Cinnamaldehyde, the third group received only Cinnamaldehyde and the fourth group received carcinogens with Cinnamaldehyde at the same time. Then, the gastric tissue of rats was isolated and evaluated for the expression of Bax, Bcl2 and TGFβ genes with real-time PCR. The data was analyzed with one-way Anova using SPSS. The results of statistical analysis showed that the expression of in the carcinogen receptor Cinnamaldehyde increased in Bax, decreased in Bcl2 but increased in TGFβ genes compared with the control group, respectively. The results of this study showed that Cinnamaldehyde can be altered by changes in the expression of genes and it is hoped that in further researches, Cinnamaldehyde be considered as a candidate for therapeutic supplements.

Genes play a very important role in the development of the cancer. The aim of this study was to evaluate three very important genes (C-fos, C-jun and P53) in wistar mice stomach tissue cancer cells designed by dimethyl hydrazine.

In this study, forty male Wistar mice, 57 weeks old, were evaluated and divided into four groups of Ten. The control group, the second group received Cinnamaldehyde-free carcinogens, the third group was healthy with the Cinnamaldehyde, and the fourth group received carcinogens with the Cinnamaldehyde at the same time.Then, the gastric tissue of mice was isolated and evaluated for the expression of C-fos, C-Jun and P53 genes. The data was analyzed with One -way Anova using SPSS.

Statistical analysis of the results showed that the expression of C-fos, C-Jun and P53 genes in the carcinogen receptor with the Cinnamaldehyde was increased compared to the control group. This increase was statistically significant for two genes C-fos (P = 0.0146) and P53 (P = 0.0212) and for C-Jun gene (P = 0.01604) this increase was not significant.

The results of this study showed that Cinnamaldehyde can alter the expression of important genes C-fos, C-Jun and P53 that are effective in causing gastric cancer.