جستجوی مقالات مرتبط با کلیدواژه "diseases" در نشریات گروه "زیست شناسی"

Moonlight proteins are a subset of multifunctional proteins in which more than one independent or usually distinct function occurs in a single polypeptide chain. Analyzing the interactive networks of proteins in the cell makes it possible to understand how complex processes cause disease. With the help of systems biology, larger and more complex systems can be studied, and the molecular basis of several diseases can be considered. The proteins of the human organism that are moonlight are mostly involved in cancer, anemia, and neurodegeneration. In this work, we created a subnet according to the human PPI network, in which the nodes, the proteins that cause the three selected diseases, and the edges, are the connection of these proteins with each other. We measured the power of the indirect effects of non-disease mediators between the three disease groups and identified key disease-binding intermediate proteins. The results show the relationship between mediator role and centrality and between mediator role and functional properties of these proteins. We have shown that a protein that plays a key indirect mediator between two diseases is not necessarily a hub in the PPI network. Therefore, as hub proteins are considered, intermediate proteins should be considered. We have observed that the mediators between anemia and neurodegeneration diseases are functionally important in the cell. The mediator proteins suggested herein should be experimentally tested as hypothetical disease-related proteins.

Wearing an inappropriate bra may result in damage to the breasts, various breast diseases, or skin allergies. This study aimed to change the fabric used in different components of the bra to reduce tension and increase breast comfort during normal daily activities of women.

 Two types of commercial bra (a regular bra and a sponge bra) were modified in the gore, sidebands, and the back band using two different types of plain-knitted fabric including polyester-lycra and viscose-lycra. To assess breast movement comfort, we measured tension changes in the bra due to breast movements during normal activities using metal-thread voltage sensors located in three parts: under the cup, the bottom of the back band, and the bottom of the gore.

 The slope of the voltage-time diagram is considered as a measure of the elongation changes in the bra during movement. The slope values for the sponge bra with the sensor at the bottom of the cup were 0.0039, 0.0057, and 0.0096 for the three common movements in the experiment, and those for the regular bra were 0.0019, 0.0039, and 0.0059. Greater voltage changes in the sponge bra compared with the regular bra indicates more tension on the breast and less ease of movement under the cup for the consumer. Using polyester-knitted tape on the sides and back of the regular bra significantly reduced tension (P value <0.05) and increased comfort.

The resuts of the study indicate differences in breast movement comfort in different bra designs. Therefore, the appropriate use of different elastic fabrics in the design of bras for ordinary and everyday use of women is an important consideration in the prevention of breast diseases.

The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free radicals. A balance between free radicals and antioxidants is necessary for proper physiological function Oxidative stress is a phenomenon that reflects an imbalance between the production of free radicals and antioxidants.

This article is a review one. The related investigations were searched from articles and reliably published texts. Different databases were explored based on appropriate keywords.

Oxidative stress can seriously alter the cell membranes and other structures such as proteins, lipids, deoxyribonucleic acid (DNA) and carbohydrates. Oxidative stress is one of the most effective factors in the incidence of many diseases. The present review provides a brief overview of oxidative stress-mediated cellular damages and role of oxidative stress in the connection with human diseases such as Cardiovascular disease, Stroke, Diabetes, Diabetic Nephropathy, Parkinson, Huntington, Alzheimer, Autism, Cancer and other diseases like Aging.

This article reviews on the factors that cause oxidative stress in the human body and the diseases that are associated with it.

The purpose of this article is to evaluate the effect of oligosaccharide prebiotic consumption on reducing the risk of diseases such as diabetes, high blood pressure, fat and bowel cancer. In people of different ages, consumption of oligosaccharide prebiotics has played a very effective role in intestinal function. In general, it can be noted to evaluate the extent of decreased glucose uptake in diabetics, fat loss, decreasing sensitivity in breastfed infants and increase the excretion and relief of chronic constipation in the elderly. Also in research on improvement intestinal function, results of oligosaccharides in women and men have been associated with improved performance and reduce abdominal pain, bloating and change intestinal function.

 The purpose of this study was to collect, identify the distribution and medicinal plants uses in Zagheh and Biranshahr areas. Due to the necessity of identifying the medicinal species, we used questionnaires to collect information on the use of medicinal plants by native people in these areas. After transferring the samples to the herbarium of the University of Lorestan for each plant species, their medicinal and traditional uses were coordinated with other available reliable sources. Based on the results, 218 medicinal species were identified from 55 families out of which 35 species belonged to Asteraceae, 21 species to Fabaceae, 19 species to Lamiaceae, 15 species to Liliaceae, 11 species to Rosacea, 10 Species to Brassicaceae, 9 species to Apiacea, 7 species to Poaceae and others belonged to different families. Among the 218 introduced species, 110 species were widely used for most of the populations in the studied area. The highest consumption of medicinal plants in the field of ethnobotanical related to relieve digestive problems (36%), respiratory (16%), blood sugar and lipid lowering (10%), urinary tract diseases (8%), skin diseases (5%), oral and dental problems (5%), and ocular diseases (2%). Evaluation of the results were showed that there is a wide variety of medicinal plants in the Beyranshahr and Zagheh areas that their therapeutic applications are common in Iranian traditional medicine and research on these medicinal plants can be a way to explore new drugs in the field of treatment.