جستجوی مقالات مرتبط با کلیدواژه « ferritin » در نشریات گروه « زیست شناسی »

Thalassemia major is the most common hemolytic anemia in Iran and the world that causes an increase in complications in patients, one of the most important of which is liver complications. Therefore, this study aimed to evaluate the level of liver enzymes and their relationship with ferritin and the frequency of blood transfusions in patients with thalassemia. This study was performed on 73 patients with thalassemia major. Demographic, clinical and laboratory information were recorded from the medical files. Data were analysed using SPSS version 22 software. Our study showed significant increasing trend in the AST, ALT and ALP levels in thalassemic patients. However, these changes were not statistically significant amount patients with different frequencies of blood transfusion (p>0.05). Among liver enzymes, just AST and ALT had significant correlations with serum ferritin (p<0.001). In addition, serum ferritin levels of more than 1625 mg/dl could predict the abnormal liver enzymes with the highest sensitivity (59%) and specificity (100%) when considering ALT and AST levels as diagnostic measures for liver problems. Due to the high prevalence of liver damage in thalassemia patients, serum ferritin in combination with the other factors can be applied as a suitable index for assessment of the liver function.

Tumor necrosis factor (TNF) and interferon gamma (IFN-γ) are pro-inflammatory and anti-inflammatory cytokine that is central to the development of autoimmune disease, cancer, and protection against infectious pathogens. A case-control study was conducted in the AL HUSSAIN Teaching General hospital in Thi-Qar governorate with a total of 190 individuals involved in the current study, 95 of them were infected with SARC COV 2, and 95 were healthy as control group. Serum was collected from each of them to assess the levels of The, TNFα, INFα, ferritin, D- dimer. TNF-α level increased significantly (P<0.05) (67, 50.6 and 15.25Pg/L), IFN-γ level significantly reduced (P<0.05) (21, 17 and 6.2IU/L), serum ferritin was significantly increased (P<0.05) (685.2, 395, and 87ng/ml). At the last one D dimer (1.7, 0.9 and 0.05mg/L) in the both patient groups (infected and non-infected) and healthy persons. The mean of TNFα, INFα concentration were higher in patients than control group (P<0.05).

The effects of magnetic fields (MF) on germination and early growth parameters, redox state and the activity of antioxidant system were investigated in soybean (Glycine max L. Merrill) seedlings. The seeds were imbibed in water and then were exposed to a 30 mT static magnetic field (SMF) and a 10 kHz electromagnetic field (EMF) for 4 days, each 5 h. Water uptake of seeds increased after 40 and 120 minutes of the treatment with MF. In comparison with the control group, exposure to EMF significantly increased germination percent of the seeds and vigor index I, II of seedlings while SMF significantly increased vigor index II but had no effect on seed germination. The ratio of fresh weight to dry weight and ferritin content of both MF-treated groups was significantly higher than those of the control group. Treatment with EMF improved radical scavenging capacity of seedlings and reduced membrane leakages. Exposure to MF also protected seedlings from the risk of increase of internal calcium content. The results provide us with a new approach for application of magnetic fields in order for growth promotion of strategic crops.