جستجوی مقالات مرتبط با کلیدواژه "hiit" در نشریات گروه "زیست شناسی"

Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand, which leads to be changes in liver enzymes with structural and functional changes in the liver. The aim of this study was to study changes in liver enzymes and insulin resistance index after HIIT and royal jelly in obese rats with type 2 diabetes.

The statistical sample of the present study was 36 obese male rats with an average weight of 409 gr. After 20 weeks of high-fat diet, rats became diabetic by intraperitoneal injection of 25 mg/kg STZ body weight. Mice with fasting glucose between 150 and 400 mg /dl were considered to have type 2 diabetes. Diabetic rat in 4 groups of control (N=6), HIIT (N=8), royal gel (N=7), HIIT& Royal gel (N=8) group done and Accomplished Eight weeks of HIIT, 5d/w with intense 2-minute intervals of 80 to 90% VO2max and one-minute rest intervals with 50 to 56% VO2max. Royal jelly was given by gavage at the rate of 100 mg / kg 5 days a week. At the end of the protocol, blood samples were taken and liver enzymes and glucose were measured using an auto-analyzer and insulin was measured using a laboratory kit and analyzed using one-way and two-way analysis of variance and post hoc test.

showed that in comparison with the control group, HIIT led to a significant decrease in glucose and insulin resistance index and intermittent exercise resulted in a decrease in liver enzymes ALT, AST and ALP compared to the control group. The ALP decrease was significant (P = 0.001).

It seems that HIIT and consumption of royal jelly can help reduce liver enzymes and improve liver status in rats.

Type 2 diabetes is the most common endocrine disease that can cause damage and cell death or apoptosis. The aim of this study was to investigate the expression of apoptotic and anti-apoptotic gene of heart tissue and insulin resistance index after intense intermittent exercise and consumption of thyme honey in diabetic type 2 rats.

The statistical population consisted of rats. After 20 weeks of high fat diet and injection of STZ became diabetic. Rats in 4 groups: control(n=6),HIIT(n= 8),thyme honey(n= 6),HIIT-thyme honey (n=8) trained HIIT for eight weeks, five sessions per week with intense 2-minute intense alternation with 2 to 8 alternations and with 80 to 90% vo2max and one-minute rest alternation with 50 to 56% vo2max.Thyme honey was given by gavage at a rate of 3g/kg 5days a week. Glucose, insulin and expression of Bax and Bcl2 genes and their ratio was calculated. Statistical analysis was performed using two-factor analysis of variance test and determining the effect size and Bonfroni post hoc.

HIIT and thyme honey decreased Bax gene expression and increased Bcl2 expression in heart cells (P<0.05). HIIT and thyme honey in diabetic rats led to improved glucose and insulin levels and decreased insulin resistance index. It also decreased the expression of Bax gene and increased the expression of Bcl2 (P<0.05).

HIIT with thyme honey led to improved glycemic profile and changes in glucose and insulin levels, as well as positive and appropriate changes in the expression of cardiac and anti-apoptotic genes.

Limiting cancer-induced cardiac atrophy is a highly important for improving the survival rates and quality of life in cancer patients. The purpose of this study was to evaluate the effect of 10 weeks of high-intensity interval training (HIIT) on cardiac muscle weight, NF-kB protein expression, and expression of Atrogin-1 and MuRF-1 genes in the heart muscle of breast cancer–bearing female mice.

In this experimental study, 12 BALB/c mice with induced breast cancer were divided into control and HIIT groups. The HIIT protocol consisted of six intervals of running at 85%-90% V̇O2 peak, interspersed with 90 seconds of active rest, and five minutes of warm-up and cool-down. The left ventricular tissue was extracted 24 h following the last training session. Western blotting was used to measure protein levels of NF-kB, and quantitative real-time polymerase chain reaction was used to measure Atrogin-1 and MuRF-1 expression in the heart tissue. Data were analyzed using an independent t test at a 0.05 significance level.

The mean cardiac muscle weight in the HIIT group was greater than in the control group (P < 0.001). A significant reduction in NF-kB protein levels (P = 0.004) and expression of Atrogin-1 (P < 0.001) and MuRF-1 (P < 0.001) were observed in the HIIT group when compared with control group.

Ten weeks of HIIT may inhibit NF-kB/Atrogin-1/MuRF-1 axis, leading to decreased atrophy and increased heart weight in mice with breast cancer.