جستجوی مقالات مرتبط با کلیدواژه "ldl" در نشریات گروه "زیست شناسی"

Diabetes mellitus is a metabolic disorder that is created by hyperglycemia and impaired insulin secretion, resistance to insulin action or both. Researches show that aqueous extracts of white tea has an antioxidant properties but few studies have been conducted on the effects of diabetic and hyperlipidemic. The aim of this study was to evaluate the effect of aqueous extract of white tea on the lipid profile and blood glucose in streptozotocin-induced diabetic rats. In the experimental study, 32 male Wistar rats were randomly divided into 4 groups of 8 were; First group, control group that received standard diet and a daily 1ml of distilled water via gavage; the second group, streptozotocin-induced diabetic rats; the third group, healthy rats aqueous extract of white tea (1.5 percent) were consumed; the forth group, diabetic rats that were consumed aqueous extracts of white tea (1.5 percent). After the treatment period (30 days) to determine blood glucose levels and lipid profile was performed and the data were analyzed with SPSS software (P<0.05). A significant decreases in serum levels of glucose, LDL, cholesterol and triglyceride and significant increase in levels of HDL and weight were observed in the group receiving aqueous extract of white tea (P<0.05). The results showed that aqueous extracts of white tea decreases serum levels of glucose, triglycerides, total cholesterol, LDL and HDL cholesterol levels significantly (P<0.05). The aqueous extracts of white tea is effective for hyperglycemia and hyperlipidemia in diabetic rats.

Today, medicinal plants are in the focus of attention because of their roles in treatment of many diseases. The aim of this study was to determine the hypocholesterolemic effect of Trigonella Foenum Graecum.L(Fenugreek) seeds powder and its comparison with atorvastatin on high cholesterol diet fed rats.

Forty male rats weighing 180–200g were monitored for two weeks and then were randomly divided into four groups of 10 each: group1(fed with normal diet: ND), group2, fed with high cholesterol diet, HCD(ND mixed with 2 cholesterol+ 0.5 cholic acid), group3( fed with HCD mixed with fenugreek seeds powder, 8 g/kg bw/day: HCD+FEN ), group4 (fed with HCD supplemented with aqueous emulsion of atorvastatin, 0.5mg/kg bw/day, administered via oral feeding tube: HCD+Ator). After 6 weeks, the serum levels of triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-c), alanine aminotransferase (ALT) and aspartic aminotransferase (AST) and fasting blood sugar (FBS) were assayed. Low density lipoprotein cholesterol (LDL-c) was estimated by Friedewald equation.

In groups 3 and 4, the serum levels of cholesterol, triglyceride, LDL-c and VLDL-c, ALT and FBS decreased (p<0.001) and serum level of HDL-c increased (p<0.05) as compared to group 2.

Fenugreek has hypolipidemic and hypoglycemic activities in high cholesterol diet fed rats and ameliroate high cholesterol diet induced dyslipidemia. Fenugreek seeds powder has shown significantly less potent hypolipidemic and hypoglycemic activities than atorvastatin.