جستجوی مقالات مرتبط با کلیدواژه « Wound » در نشریات گروه « زیست شناسی »

Prolongation of wound healing time can be led to chronic infections. Therefor, to achieve infection preventive methods to accelerate of wound improvement process is one of essential needs of Human. In this study, the effects of methanolic extract of Holothuria leucospilota was investigated on restoration of created wound in rat skin.  Methanolic extracts of collected sea cucumber from depth of 10 to 15 meters was prepared by rotary. The amount of  0.5 and 1 gr of obtained extraction were added to base ointment. In continuing, 40 rats (average mean of 185±5 gr) were divided into 4 groups which included control, sham (base cream), 0.5% ointment and 1% ointment. Wound (diameter of 6±1 mm) was created on rats’ skin by punch biopsy.  Each group were treated (1ml) with prepared concentrations ointment during 13 days. On days of 0, 4, 7, 10 and 13, the wound improvement process was investigated and the diameter of the wounds was measured. According to results, accelerate the wound recovery process was more obvious in treated groups with 0.5% and 1% ointment compared to control and sham groups. Also, there was significant different between treated group with 1%, sham and control during days of 7, 10, 13 (P<0.05).

Wound healing is a complex programmed sequence of cellular and molecular processes. The objective of the present study was to evaluate the ability of earthworm’s hydro-alcoholic body extract (EBE) to heal the experimental skin wound in goldfish (Carassius auratus gibelio).

Fish (independent triplicate, 14/group), for 14 days, were divided into 5 groups 1) negative control (Unwounded); 2) pseudo-control (sham): wound treated with EBE carrier (mixture of castor oil and white vaseline); 3) Positive control: wound treated with sodium phenytoin 1%; 4) 1 mg/gr EBE-treated wound, 5) 10 mg/gr EBE-treated wound. In this study, macroscopic and microscopic evaluations and collagen turnover (Hydroxyproline content) in the skin, along with determination of lysozyme activity in blood sera were carried out.

In fish in group 4 (1 mg/gr EBE-treated wound), an increase in the epithelium diameter, good presence and appropriate synthesis of collagen with and low edema in dermis; increased hydroxyproline content; and elevated blood lysozyme activity were observed comparing to other groups.

Our results revealed that application of 1 mg/gr EBE might be as an effective medicinal material in the process of animal wound healing particularly in aquatics.

A number of management and nutritional strategies are used to induce reproductive maturation and early puberty in sturgeons. Hormonal implants can have a promoting effect on sexual maturation and ovulation in sturgeons, but the surgical procedure for implantation leaves an external injury on the skin leading to further side effects on fish body. In this study, 20 three-year-old great sturgeon (6.9±0.2kg) were maintained in concrete tanks for 168 days and implanted by cutting a small incision on fish abdomen. Implantation capsules contained 0, 3, 6 and 12mg 17-β estradiol (E2) per kg of body weight of fish and administrated each 45 days. The wound index and weight change trend of the implanted fish was evaluated every three weeks after implantation. Results showed that there were no significant differences between implanted fish and control fish in terms of wound healing index and after 3 weeks relative improvement was achieved. Weight change in the first, second and third biometry was not significantly different (P>0.05). However, there was a significant difference in the fourth biometry between E2 implanted fish and control in terms of weight and growth performance indices (weight gain, specific growth rate and condition factor) (P<0.05), but there were no significant differences between fish that was implanted with different levels of E2 (P>0.05). These findings suggest that E2 implantation alters physiological pathways by partitioning energy from muscle growth toward support of maturation-related processes. This study showed that E2 can influence fish weight, but the wound healing process was almost unchanged and independent.

In the study , synergistic effect of green tea (camellia sinesis) extract and treadmill aerobic exercise on wound healing in streptozotocin induced diabetic mice has been investigated.  

The number of 50 male mice with the approximately weight of 30-35 gram health and adult are put in 5 groups: non diabetic – immobile , diabetic - immobile, diabetic exercise - diabetic and  immobile with green tea extract , diabetic with synergism of exercise and green tea extract. After inducing of diabetes using sterptozotocin mice were killed and in days 3-7-14-21 macroscopic and histopathologic analysis were performed.  

The results indicated that in synergistic group of  green tea extract and treadmill exercise , wound area decreased and fibroblast  increased after 7 days significantly compared with other groups (p<0.001).PMN cells decreased after 3 days significantly compared with other groups (p<0.001).  

The results suggest that green tea extract and treadmill exercise have synergistic effect on wound healing in diabetic mice.

Diabetes is one of the reasons for delayed wound healing; as the fruit of blueberries, Cornus mas, possesses high content of antioxidants, therefore, this study aims to investigate the extract of this fruit on wound healing in a male rat of Wistar strain affected by diabetes.In this study, 48 male rats of Wistar strain were divided into 4 groups of 12. After affecting these groups to diabetes (except control group), there was created a wound at the back of the rat in all 4 groups; the length of the wounds in the groups were investigated up to 21 days; (1) control group: with no blueberries extract and ocerin treated on their wounds, called as healthy group; (2) Shem Group: they include a group of diabetics rats who were treated by ocerin (twice per day); (3) Experimental Group 1: they included a group of diabetics rats who received no ocerin and extract; (4) Experimental Group 2: they include the diabetics group who treated by the ointment of blueberries extract (twice a day).Results of comparing the mean of wounds length in the investigated groups indicate that the experimental group 2 had significant reduction up to p ≤ 0.01 than Shem and experimental1 groups. By reducing the blood glucose and modifying some biochemical factors, blueberries makes treatment effect on diabetes. According to the results of this study, blueberries ointment may accelerate skin wound healing in the healthy and diabetic samples.

Skin ulcers and diabetic foot ulcers are an important issue in medicine. Diabetes is one of the most common metabolic diseases of the endocrine system. Artemisia pharmacological, particularly effects on diabetes. The aim of this study was to compare the healing effects of alcoholic extract of Artemisia in the process of healing and skin wounds in normal and diabetic rats is quickly closing. Overall, 20 adult male Wistar rats were used. The rats were divided into four groups of five controls (without diabetes and treatment), sham (diabetes treatment Eucerin), Experimental 1 (diabetes without treatment), Experimental 2 (diabetes treated with alcoholic extract of Artemisia) were divided. Three groups of rats were made diabetic using STZ. Over 2 cm wound on the skin of spinous were created in all groups. The experimental group and the experimental group 2 with wormwood extract 1 Eucerin day with a dose of 100 mg Barba topical treatment over a period of 21 d, respectively. Wound healing was evaluated by macroscopic and microscopic. Wound healing in experimental groups 1 and 2 was treated with than the alcoholic extract of Artemisia control group showed the highest rate. Wormwood extract leads to topical wound healing in diabetic rats and material contained in Artemisia cause, faster wound contraction, and the healing.

Aim: In the present investigation, the effects of grape seed (Vitis Vinifera) alcoholic extract were examined on skin Histomorphometric wound healing changes in diabetic Wistar rats.
Material and forty eight male wistar rats were divided into four groups: negative control, positive control, the first experimental and the second experimental. In all of treated rats, a scar in the length of three centimeter was created on the left of the vertebral column. The wound healing was evaluated microscopic as well as macroscopic. The methods Mann – Whitney, Kruskal – Wallis were used for data analyses. The used software was SPSS ver. 16.
agglutination in diabetic groups was longer than normal, while the process in the group treated with V. vinifera was quicker than the control and also first experimental groups, respectively.
the obtained results showed that V. vinifera ointment accelerate the wound healing in normal and diabetic samples.

Daily increasing of bacteria resistance (specially Staphylococcus aureus) to various antibiotics in particular penicillin and methicillin has always led the scientists to look for new medicines.
600 g of Fulgensia fulgens was collected from KaneGonbad mountains in Ilam province, the methanol extract was prepared by soxhle. In vitro antimicrobial activity of the extract against two gram-positive bacteria (S. aureus and Entrococcus faecalis) and two gram-negative bacteria (Pseudomonas aeruginosa and Escherchia coli) was tested by the use of disc diffusion method and microdilution (with determination of MIC and MBC). Wound was made on the dorsal surface of therat and wound infections caused by S.aureus for determination of in vivo antibacterial effect. Than rats were randomly divided into three groups; control, treated with tetracycline ointment and treated with 10% ointment of F. fulgens extract. Finally, wound areas wear measured on days 3, 5, 7, 9 and 11.
Average inhibitory zone diameter of methanolic F. fulgens extract against S. aureus ranged between 11.21 mm to 33.01 mm. According to the wound area on 11th day, it could be concluded that there was a statistically significant difference between the control group (0.63 cm2) and two treatment groups (0) (pDiscussion and According to the results, the methanol extract of F. fulgens in the treatment of infections as S. aureus can be replaced by chemical antibiotics.