جستجوی مقالات مرتبط با کلیدواژه « tricyclic antidepressant » در نشریات گروه « شیمی »

First principles calculations were performed to study the neurotransmitters, tricyclic antidepressant drugs and (5,5) carbon nanotube in the gas phase and solution media for comparison purposes. All calculations were performed using DMol3 code in materials studio 5.5. The simulation results revealed that, the nitroxazepine is quite a reactive drug, so that it can act as the electron donating specie in its interacting with carbon nanotube. In addition, the nitroxazepine is the electron acceptor and serotonin and norepinephrine is the electron donor. To explain the interaction of the carbon nanotube, serotonin, and norepinephrine with nitroxazepine, their local reactivity was analyzed through Fukui functions. The results show that the hydrogen bonding between oxygen atoms of the nitroxazepine and OH of the serotonin and norepinephrine has been assigned as the dominant interaction. In order to gain a deeper understanding of the interaction between the nitroxazepine with the carbon nanotube, serotonin and norepinephrine, calculations of binding energies, quantum molecular descriptors, the most important modes of the vibrational frequencies and density of states (DOS) have been carried out.

Biotransformation of antidepressant drugs is said to affect their pharmacological profile and subsequently alter their treatment efficacies. Imipramine and amitriptyline are the major drugs used for the management of manic depression at the Ankaful psychiatric hospital in Ghana. Recent reports have shown that some patients stay longer on this therapy than expected, while others do not get well at all. Herein, we report a modified solid phase extraction (SPE) method for the extraction of these antidepressant drugs; imipramine, amitriptyline and their respective metabolites, desipramine and 10-hydroxyamitriptyline from urine samples of five adult manic depressed patients. The compounds were simultaneously analyzed by gas chromatography-mass spectrometry (GC-MS). The calibration curves were linear over a range of 10-100 µg/L for all the analytes with the square of the regression coefficient (R2) ranging from 0.990 to 0.997. Analyses of the drugs and their respective metabolites over a 40 day period gave an average of 3.65 µg/L 10-hydroxyamitriptyline with negligible levels of amitriptyline. An average of 27.01 µg/L desipramine was also recorded against 10.30 µg/L of imipramine. These high levels of metabolites and relatively low amounts of the parent drugs recorded in the urine samples could be the main cause of the patients staying longer on the therapy and the resultant abscondment of one of them.