جستجوی مقالات مرتبط با کلیدواژه « Mefenamic Acid » در نشریات گروه « شیمی »

In this work, a novel series of mefenamic acid analogs were developed and synthesized with the goal of developing a lead chemical that has anti-inflammatory efficacy and avoids the adverse effects of NSAIDs. Molecular docking analysis was performed by recruiting the ligands, COX-1 and COX-2 to identify the best-fitted molecule using AutoDock software. Afterwards, the compounds were synthesized and analyzed. To assess the drug's efficacy, the compounds were subjected to in vivo analgesic and anti-inflammatory experiments. Most of synthesized ligands have greater binding free energy than mefenamic acid on COX-1. When compared to the positive control, the compounds 2-(2,3-dimethylphenylamino)-N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxothiazolidin-3-yl) benzamide, 2-(2,3-dimethylphenylamino)-N-(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)benzamide, 2-(2, 3-dimethylphenylamino)-N-(4-oxo-2-p-tolylthiazolidin-3-yl) benzamide and 2-(2,3-dimethylphenylamino)-N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl) benzamide, 2-(2,3-dimethylphenylamino)-N-(2-(4-nitrophenyl)-4-oxothiazolidin-3-yl)benzamide demonstrated a larger or comparable proportion of analgesic and anti-inflammatory action respectively. Furthermore, the selected compounds “2-(2,3-dimethylphenylamino)-N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxothiazolidin-3-yl) benzamide”, and “2-(2,3-dimethylphenylamino)-N-(4-oxo-2-p-tolylthiazolidin-3-yl) benzamide” seemed to have the least ulcerogenic activity. These findings show that some of the newly created mefenamic acid analogs may be selected as lead compounds due to their significant biological properties without ulcerogenic activity.

In this research work, a serious of novel polymeric prodrugs of mefenamic acid was prepared in order to minimize of the mefenamic acid side effects. Glycidyl methacrylate was first copolymerized with acrylamide and methyl methacrylate by free radical solution polymerization method, using α,ά-azobisisobutyronitrile as an initiator at 70±2 oC. Mefenamic acid, as a non-steroidal anti-inflammatory drug, was then attached to the synthesized copolymers via the hydrolysable ester bonds by transesterification procedure in the presence of N,N'-dicyclohexylcarbodiimide to give polymeric prodrugs. The synthesized copolymers and polymeric prodrugs were characterized by various techniques such as FT-IR, 1HNMR and 13CNMR to confirm their structures. These polymeric prodrugs were hydrolyzed in cellophane membrane dialysis bags containing aqueous buffer solutions (pH 1, 7.4 and 8.5) at 37 oC. Analysis of the hydrolyzing solutions by UV spectrophotometer at selected intervals showed that the drug could be released by selective hydrolysis of the ester bond from side chain of drug moiety. The release profiles of drug indicated that the hydrolytic behavior of polymeric prodrugs strongly depends on the hydrophilicity of polymer and the release rate of mefenamic acid at alkaline medium is higher than other mediums. These developed systems would be useful for the development of pH-sensitive polymeric prodrugs in controlled release systems.

In this work, we report the novel green synthesis of Co3O4 nanoparticles (Co3O4NPs) using extract of Elaeagnus angustifolia leaves plant as a mild and non-toxic stabilizing agent. The synthesized Co3O4NPs was characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and FTIR spectroscopy. In order to obtain its applicability, the carbon paste electrode (CPE) modified with the Co3O4NPs and graphene oxide (GO) (Co3O4NPs/GO/CPE) was fabricated as anew sensor for trace determinations of dopamine (DA) and mefenamic acid (MFA). The electrochemical investigations on DA and MFA were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamprometry (CA) methods. The results showed that Co3O4NPs as the modifier in the proposed sensor can accelerates the electron transfer reactions of DA and MFA. Under the optimum conditions, the electrode provides a linear response versus DA and MFA concentrations in the range of 0.5-250 µM and 1-500 µM, with a detection limit of 0.15 µM and 0.3 µM, respectively. The modified electrode exhibited some advantages such as convenient preparation, good stability, high sensitivity and selectivity toward DA and MFA determination.

Mefenamic acid (Mef) is a derivative of phenylanthranilic acid (Paa). As a drug of the NSAID group, it reduces the sensation of pain and suppresses the development of inflammation in the human body. For its determination, in substance and dosage forms (tablets, capsules, gels) different methods of analysis are used. Ionic associate (IA) compounds of Mef and Paa with rhodamine 6G were used as electroactive substances (EAS) in the manufacture of membranes of ion-selective electrodes. Investigation of the electrochemical properties of the obtained ISEs with different contents of the EAS (1-10%) shows that they give an answer to the concentration of Mef and Paa in a solution in a wide range: 5×10-4-1×10-2 and 2×10-3-1×10-1 mol/l, with the slope of 83.1 and 89.1 mV/рС respectively. The content of the EAS in the composition of the membrane with a content of 4-8% slightly affects the basic electroanalytical characteristics of the sensors manufactured. Further, an increase in the content of the associate leads to thickening and increases the rigidity of the membrane, which causes the deterioration of the steepness value and the limits of detection of the test substance. Significant influence on the results of the work of the electrodes may alter the quantitative content of the plasticizer in the membrane. The research was carried out for membranes containing DBF of 35-75%. As a result of measurements, it was found that electrodes with content of plasticizer of 45-70% possess good electroanalytical characteristics. The operating range of the acidity of the functioning of the electrode is equal to the pH range 9-11. Stable values of electrode potentials are set within 5-10 seconds. Synthetic membranes are suitable for work for at least 4 months. Efficient techniques of the potentiometric determination of the content of mefenamic and phenylanthranilic acids in model solutions and pharmaceuticals were developed.

Pills of Mefenamic acid were  employed as effective catalysts in the three component reaction of aromatic  aldehydes,  malononitrile,  as  well  as  4-hydroxycoumarin  or  barbituric  acid  in  aqueous solution,  using  reflux  conditions  in  order  to  synthesize  derivatives  of  dihydropyrano[2,3-c]chromene and pyrano[2,3-d]pyrimidine, correspondingly. Among the benefits of this technique, higher efficiency, shorter reaction time, along with better reaction indices could be mentioned.

The electro-oxidation of epinephrine (EPI), acetaminophen (ACT) and Mefenamic acid (MEF) has been investigated by application of nickel hydroxide nanoparticles / multi-walled carbon nanotubes modified glassy carbon electrode (MWCNT-NHNPs/GCE) using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. The modified electrode showed suitable electrochemical responses for EPI, ACT and MEF determination. Under the optimum conditions the electrode provides a linear response versus EPI, ACT and MEF concentrations in the range of 0.5-180 μM, 0.1-180 μM, and 0.1-85 respectively using the DPV method. Application of CA method showed linear responses for EPI and ACT concentrations in the range of 1-600 μM and 1-500 μM respectively. The CA results for MEF showed two linear range of 1-50 μM and 60-600 μM. The modified electrode was used for determination of EPI, ACT and MEF in human serum and urine with satisfactory results.

This work investigates the potential of magnetic Fe3O4 nanoparticles as an adsorbent for separation and preconcentration of trace amounts of mefenamic acid in aquatic and biological samples, prior to spectrophotometric determination. The magnetic iron oxide nanoparticles (MIONs) were synthesized by mixing of ferrous and ferric chlorides. The possible parameters affecting the enrichment were optimized. It is shown that the novel magnetic nano-adsorbent is quite efficient for fast adsorption of mefenamic acid in pH =7.0. Various parameters affecting the adsorption of mefenamic acid on MIONs, such as pH of solution, desorbing reagent, adsorption isotherms, sample volume, amount of adsorbent and matrix effects, have been investigated. The calibration graph for the determination of mefenamic acid was linear in the range of 1.25-7.25 ng mL−1. The limit of detection, defined as LOD= 3Sb/m was 0.5 ng mL−1 (n=3) of mefenamic acid and the relative standard deviation was 3.6%. The preconcentration factor of 150 was achieved in this method. The proposed procedure has been successfully applied to the determination of mefenamic acid in biological samples such as human plasma and dextrose saline.

Electroanalysis of mefenamic acid using platinum powder composite microelectrode (PPCM) by cyclic voltammetry (CV) method in buffer phosphate has been carried out. PPCM was prepare by Pt powder and PVC in 4 mL tetrahydrofuran (THF) solvent and swirled flatly to homogeneous followed by drying in an oven at 100°C for 3 hours. The mixture was placed in 0.5 cm diameter stainless steel mould and pressed at 10 ton/cm2. Cyclic voltammetry method was performed in a three electrodes system using PPCM as a working electrode, an Ag/AgCl (saturated KCl) as reference electrode and platinum wire as the counter electrode. Electroanalysis of mefenamic acid was performed in a buffer phosphate solution (pH 4). The results of the study showed that the correlation of determination using PPCM electrode for electroanalysis of mefenamic acid was R2=0.995. Precision, LOQ, LOD and recovery of the PPCM towards mefenamic acid were found to be 1.01%, 27.94 ppm, 93.13 ppm and 100.88%, respectively. As a conclusion, PPCM electrode is very good for electroanalysis of mefenamic acid in pharmaceutical product.