جستجوی مقالات مرتبط با کلیدواژه « Ofloxacin » در نشریات گروه « شیمی »

The aim of this work is to study the degradation and mineralization of antibiotic ofloxacin in aqueous medium using the Electro-Fenton method as advanced oxidation technology. In this context, Pt/carbon-felt cell was used to investigate the influence of various parameters including initial pH, different supporting electrolytes, different metal ions as a catalyst and antibiotic concentration over the mineralization rate and instantaneous current efficiency. The chemical oxygen demand (COD) measurements during the electrolysis allowed the evaluation of the kinetic of organic matter decay and the mineralization efficiency reaches 90% COD removal at only 200 mA for 300 min of electrolysis.

Tuberculosis (TB) has been one of the main causes of morbidity, and the emergence of multi-drug resistant (MDR) Mycobacterium tuberculosis strains has become a major concern. The decrease in activity of the major anti-TB drugsincluding, isoniazid, and rifampicin is an important threat that requires an urgent therapy. Anti-TB activity of the fluoroquinolones (FQs) has been under investigation. Many FQs are active in vitro; however, only a few such as ofloxacin, ciprofloxacin, sparfloxacin, levofloxacin, Moxifloxacin, and gatifloxacin have been clinically tested. The FQs can be used in co-therapy with the available anti-TB drugs. Molecular hybridization is a concept of drug design and development based on combination of pharmacophoric moieties of various bioactive compounds to produce a new hybrid compound with improved affinity and efficacy compared with the present drugs.

An efficient and simple magnetic solid phase extraction based on the use of CoFe3O4 nanoparticles grafted multi-walled carbon nanotubes (MWCNTs) as adsorbent coupled with surfactant enhanced spectrofluorimetric detection was developed for determination of ofloxacin from biological samples. The adsorbent uses the advantages of both magnetic nanoparticles (i.e., magnetic separation) and MWCNTs (i.e., high adsorption capacity). The main factors affecting the quantitative recovery including SDS concentration, pH, extraction and desorption times, adsorbent amount, and desorption conditions were investigated in detail. Under the optimized conditions, the calibration curves were linear over a wide concentration range of 100-750 ng mL-1 with detection limit (LOD) of 23 ng mL-1. The relative standard deviation (RSD %) of 3.3% for concentration of 250 ng mL-1, n = 5 and the preconcentration factor of 93 were obtained. Finally, the proposed method was successfully applied to the extraction and preconcentration of ofloxacin in human plasma samples.