جستجوی مقالات مرتبط با کلیدواژه "nephrotoxicity" در نشریات گروه "محیط زیست"

Gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ROS) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.Materials and

in this study 36 immature female Wistar rats were divided into 6 equal groups. The control group did not receive any solution or medication. Every day The control group 1 received 200mg/kg hydro-alcoholic extract of cinnamon in Gavage form, the control group 2 received 80 mg/kg Gentimicin in intraperitoneal injection form, and empirical groups 1, 2 and 3 received 80 mg/kg Gentimicin in intraperitoneal injection form and 50, 100 and 200 mg Hydro-alcoholic extract of cinnamon in Gavage form for 14 days, respectively.

Results show that serum concentrations of uric acid in sham group II increased significantly compared to the control group at 5%, and that the concentrations of urea and creatinine in sham group II and in the experimental group I were significantly higher compared to the control group at 1%. The diameter of proximal tubules in sham group II was significantly larger compared to the other groups (p<0.05). Furthermore, the diameter of glomeruli in the experimental groups and in sham group II significantly increased compared to the control group and sham group I. 

Cinnamon extracts have antioxidant properties and somewhat reduce the negative effects of Gentamicin. Therefore, it is recommended cinnamon extracts be used to reduce Gentamicin-induced nephrotoxicity in patients

Gentimicin is an antibiotic from the family of Aminoglycosides used in the treatment of infections resulted from Gram-negative bacteria, the use of which is limited due to its nephrotoxicity. In this study the histological effect of cinnamon on the nephrotoxicity resulted from Gentimicin in rats is investigated because of the Antioxidant properties of cinnamon.Materials and Thirty-six mature female Wistar rats were divided into six equal groups. The control group did not receive any solvents or medicines. The experimental group I received Gentamicin with the daily dose of 80 mg/kg through intraperitoneal injection, and the experimental group II the daily 200 mg/kg gavage dose of hydroalcoholic extract of cinnamon. The experimental groups III, IV, and V were given the daily dose of 80 mg/kg of Gentamicin through intraperitoneal injection together with 50, 100, and 200 milligrams of cinnamon extract, respectively, by gavage for 21 days.     results indicate that the cortex diameter in experimental groups 1 and 4 increase significantly (P<0.05) compared to control group and experimental groups 2. Diameter of medulla did not increase significantly in different groups. In contrast, diameter of the proximal tubule showed a significant increase (P<0.05) in experimental groups 1, compared to other groups. Also the glomerular diameter in  the other experimental groups increased significantly compared to control group and experimental groups 2 . the results of the study show that cinnamon apart from having phenolic compounds and antioxidant properties, can cure the tubular injury resulted from Gentimicin.

Gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as Nephrotoxicity and autotoxicity. Cinnamon bark has antioxidant properties. This is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.Methods and Materials: Thirty-six mature female Wistar rats were divided into six equal groups. The control group did not receive any solvents or medicines. The experimental group I received Gentamicin with the daily dose of 80 mg/kg through intraperitoneal injection, and the experimental group II the daily 200 mg/kg gavage dose of hydroalcoholic extract of cinnamon. The experimental groups III, IV, and V were given the daily dose of 80 mg/kg of Gentamicin through intraperitoneal injection together with 50, 100, and 200 milligrams of cinnamon extract, respectively, by gavage for 21 days.   

Serum uric acid concentration in the experimental group I increased significantly compared to the control group at the 5% probability level, and urea and creatinine concentrations in the experimental groups I and III showed a significant increase compared to the control group at the 1% probability level.

Cinnamon extract was able to protect rats against Gentamicin-induced nephrotoxicity due to its contents of phenolic compounds and of other antioxidant substances.