جستجوی مقالات مرتبط با کلیدواژه « polymorphism » در نشریات گروه « محیط زیست »

An inflammatory response and an interleukin 10 (IL-10) cytokine storm were associated with serious acute lung injury and multiorgan dysfunction in patients with severe COVID-19 disease. Genetic variations affecting IL-10 levels and disease are known as single nucleotide polymorphisms (SNPs). Severe COVID-19 was more likely in older adults, those who were overweight, and smokers. Purpose To determine if COVID-19 is associated with IL-10 gene SNPs at (rs1800896) in individuals who smoke and are overweight.The participants in this study were 24 people with COVID-19 who were overweight, 25 people who smoked, 25 people who were neither overweight nor smokers (control positive), and 21 healthy individuals. The groups that were studied underwent ARMS-PCR genotyping of the IL-10 (rs1800896) SNP. Three samples had the A allele (3.2%), eight samples had the G allele (8.4%), and eighty-four samples had the AG genotype (88.4%). Within the same groups, there was a substantially different prevalence rate of IL-10 (rs1800896) alleles, with low rates of AA and GG genotypes (P< 0.0001).

Despitethe efforts conducted on the identification of species of the genus Pelophylaxfrom Iran, recent studies revealed that the taxonomy and identification of localpopulations within this genus havebeen still unresolved. Here, the morphological and morphometricvariations of waterfrog populations (Pelophylax) from different localitiesof Iran were studied.To assess suitable morphological andmorphometric diagnosis for taxonomic identification of the genus, 13morphological and 23morphometric charactersof 160 specimens were analyzed. Our result indicated P.cf. bedriagaeand Pelophylax sp.show cryptic variation in morphology and melanistic diversity.In water frogs, this characteris much more influenced by compatibility to special habitat, so its value is less to be considered as a taxonomic trait or key characterfor identification.However, the morphometricvariables of Pelophylax sp. are larger than P.cf. bedriagaefrom the west of Iran. Followinggeneralized Gloger's rule, a comparison of character states of 12 biological variables revealed that dorsal coloration of waterfrog populations become paler from north to south in eastern Iran,while the ventral part shows low variation in color.This pattern indicates the low selective value of ventral coloration in the viability of waterfrogsin eastern Iran. Moreover, natural selection stabilized olive coloration on the populations of waterfrogsliving in the green habitats of north Iran while compromisinglight grey and dark brown in contrasting ecosystems through the semi-desert and humid oases of south Iran viaa disruptive selection mechanism.

This experiment was aimed to study the association between the DGAT1 K232A polymorphism and milk production traits and somatic cell score (SCS) in Iranian Holstein dairy cows. The records of 408 animals from five dairy herds were randomly identified and then genomic DNA was extracted from blood using the modified-salting method described by Miller. RFLP-PCR was performed to obtain all the polymorphisms and two alleles, K and A were observed with frequency of 0.37 and 0.63. Genotypic frequencies of AA, KA and KK were 0.3578, 0.5515 and 0.0907, respectively. The relationship between DGAT1 K232A and milk traits and somatic cell score in the first lactation was studied. The results showed significant difference (p≤0.05) between the genotypes on milk production, fat percent but not for protein percent and SCS. According to this research, the DGAT1 K232A polymorphism can be considered for increasing milk performance traits in Holstein dairy cows in the proximal region of bovine chromosome 14.

In this study we estimated the allele and genotype frequencies of SCD1 and DGAT1 gene polymorphism. The analysis was conducted on 408 Holstein cows from five dairy herds in Isfahan province. Genotypes were identified using PCR-RFLP technique. Two genetic variants (A and V) of the SCD1 gene were observed in this experiment. The frequency of A-allele ranged from 0.49 to 0.66, while frequency of V-allele 0.34 to 0.51. Regards with DGAT1 gene, also two genetic variants (A and K) were determined that frequency of A-allele ranged from 0.54 to 0.68 and K-allele 0.32 to 0.46. It was found that these two genes were polymorphic in Isfahan Holstein cows, which suggested that could be associated with composition and production traits